S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

Product Name: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
CAS No.: 132335-47-8
Chemical Name: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
Synonyms: Duloxetine Impurity 52;Duloxetine intermediate;Duloxetine N-Methyl Oxalate;N-Methyl Duloxetine Oxalate;Duloxetine N-methyl Impurity;Duloxetine Impurity 8 Oxalate;S-(+)-N,N-Dimethyl-3-(1-naphtho;Duloxetine Impurity 8(Oxalicacid);N-Methyl Duloxetine Oxalate;Duloxetine N-Methyl (S)-Isomer Oxalate
CBNumber: CB3855078
Molecular Formula: C21H23NO5S
Formula Weight: 401.48
MOL File: 132335-47-8.mol

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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Property

Melting point:: >145°C (dec.)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C19H21NOS.C2H2O4/c1-20(2)13-12-18(19-11-6-14-22-19)21-17-10-5-8-15-7-3-4-9-16(15)17;3-1(4)2(5)6/h3-11,14,18H,12-13H2,1-2H3;(H,3,4)(H,5,6)/t18-;/s3
InChIKey: GYUDMXKAVMKVPS-QAYAHANANA-N
SMILES: N(C)(C)CC[C@H](OC1=C2C(C=CC=C2)=CC=C1)C1SC=CC=1.C(O)(=O)C(O)=O |&1:5,r|
CAS DataBase Reference: 132335-47-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H302Harmful if swallowed

H313May be harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: M303880
Product name: N-MethylDuloxetineOxalate
Packaging: 10g
Price: $150
Updated: 2021/12/16

TRC

Product number: M303880
Product name: N-MethylDuloxetineOxalate
Packaging: 25g
Price: $300
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 66065
Product name: N-MethylDuloxetineOxalate
Packaging: 1g
Price: $640
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001199
Product name: (S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THINYL)PROPANAMINE OXALATE
Purity: 95.00%
Packaging: 1G
Price: $739.2
Updated: 2021/12/16

Matrix Scientific

Product number: 092416
Product name: (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate
Purity: 95+%
Packaging: 10g
Price: $756
Updated: 2021/12/16

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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A duloxetine impurity.

Synthesis

321-38-0

144-62-7

132335-49-0

132335-47-8

General procedure for the synthesis of (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate from 1-fluoronaphthalene, oxalic acid and R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol: R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol (2.0 g, 0.011 mol) was was dissolved in dimethylacetamide (100 mL) and a suspension of 60% sodium hydride (463 mg, 0.012 mol) was added slowly and dropwise. The reaction mixture was heated at 70°C with stirring for 20 minutes. Subsequently, 1-fluoronaphthalene (1.27 mL, 0.012 mol) was added dropwise to the reaction system and heating was continued with stirring at 110 °C for 60 min. After completion of the reaction, the reaction mixture was diluted with water and extracted twice with ether. The organic phases were combined, washed sequentially with water and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the oily product (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine (3.28 g, 75.6% yield).

References

[1] Patent: JP2016/172704, 2016, A. Location in patent: Paragraph 0027; 0053

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Suppliers

Canada 1 China 162 Europe 2 Germany 1 India 11 United Kingdom 2 United States 16 Global 195

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View Lastest Price from S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate manufacturers

Chemwill Asia Co.,Ltd.

Product: S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory 132335-47-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 largest production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)- 132335-47-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-26

132335-47-8, S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalateRelated Search:

Dimethyl sulfoxide Dimethyldimethoxysilane Basic Green 4 Sodium oxalate Cephalothin sodium Tetrahydrothiophene Isopropylamine Dimethyl disulfide Diethyl oxalate Dimethyl fumarate Dimethyl carbonate LITHIUM OXALATE Diethoxydimethylsilane ETHANE Dimethyl sulfate Dimethyl ether Dacthal N,N-Dimethylformamide

S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-

Duloxetine N-Methyl Oxalate

(S)-(+)-N,N-diMethyl-3-(naphthloxy)-3-(2-thienyl)

(S)-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thinyl)Propanamine Oxalate

(S)-(+)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-propanamine oxalate

(S)-(+)-N,N-DIMETHYL-3-NAPTHTOXY-(2-THIOPHENE) PROPYLAMINE OXALATE

Duloxetine intermediate

S-(+)-N1N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINE OXALATE

(S)-(+)-N,N-dimethyl-3-(1-naphthloxy)-3-(2-thienyl)prpylamine oxalate

S(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamineoxalate

(S)-(+)-N,N-DIMETHYL-3-(1-NAPTHTALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINEHYDROCHLORIDE

S-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANEMAINEOXALATE

(S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIENYL)-PROPANAMINE OXALATE, DULOXETIN INTERMEDIATE

S-(+)-N,N-Dimethyl-3-(1-phthoxy)-3-(2-thienyl)-1-propylamine oxalate

s-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate

(S)-N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine ethanedioate (1:1)

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate

2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, eth

(S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIOPHENE)-PROPYLAMINE OXALATE

S-(+)-N,N-Dimethyl-3-(1-naphtho

(S)-N,N-DiMethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanaMine Ethanedioate

N-Methyl Duloxetine Oxalate

(S)-N,N-DiMethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine oxalate

S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory

N,N-dimethyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine

Duloxetine Impurity 8 Oxalate

Duloxetine N-Methyl (S)-Isomer Oxalate

(S)-(+) N,N-dimethyl-3-(1-napthalenyloxy)-3-(2_thieyl)prapanamine oxalate

Duloxetine N-methyl Impurity

Duloxetine Impurity 52

S-(+)-N,N-dimethtl-3-(1-naphthoxy)-3-(2-thienyl)-1-propanamine oxalate

2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, ethanedioate (1:1), (γS)-

(3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine Oxalate)

Duloxetine Impurity 8(Oxalicacid)

(3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate

(3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine

<i>N</i>-Methyl Duloxetine Oxalate

132335-47-8

C19H21NOSC2H2O4

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds