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2-[2-(2-methoxyethoxy)ethoxy]ethylamine

Product Name
2-[2-(2-methoxyethoxy)ethoxy]ethylamine
CAS No.
74654-07-2
Chemical Name
2-[2-(2-methoxyethoxy)ethoxy]ethylamine
Synonyms
2-(2-(2-methoxyethoxy)ethoxy)ethan-1-amine;MPEG3-NH2;NH3-PEG3-OME;m-PEG3-Amine;MeO-PEG3-NH2;Methyl-PEG3-amine;H2N-(CH2CH2O)3-Me;3,6,9-Trioxa-1-aminodecane;3,6,9-Trioxadecane-1-amine;2,5,8-trioxatridecane-10-aMine
CBNumber
CB3899124
Molecular Formula
C7H17NO3
Formula Weight
163.21
MOL File
74654-07-2.mol
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2-[2-(2-methoxyethoxy)ethoxy]ethylamine Property

Boiling point:
106℃ (11 Torr)
Density 
0.978±0.06 g/cm3(Predicted)
refractive index 
1.4395 (589.3 nm 20℃)
storage temp. 
2-8°C
solubility 
Soluble in Water, DMSO, DCM, DMF
form 
Oil
pka
8.74±0.10(Predicted)
color 
Colorless to light yellow
InChI
InChI=1S/C7H17NO3/c1-9-4-5-11-7-6-10-3-2-8/h2-8H2,1H3
InChIKey
OKUWOEKJQRUMBW-UHFFFAOYSA-N
SMILES
C(N)COCCOCCOC
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Safety

HS Code 
2922190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901158
Product name
2-(2-(2-Methoxyethoxy)ethoxy) ethanamine
Purity
≥95%
Packaging
5G
Price
$332
Updated
2025/07/31
TCI Chemical
Product number
M3686
Product name
m-PEG3-Amine
Purity
min. 95.0 %
Packaging
200MG
Price
$90
Updated
2025/07/31
TCI Chemical
Product number
M3686
Product name
m-PEG3-Amine
Purity
min. 95.0 %
Packaging
1G
Price
$270
Updated
2025/07/31
TRC
Product number
M220438
Product name
2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
M220438
Product name
2-(2-(2-Methoxyethoxy)ethoxy)ethanamine
Packaging
2.5g
Price
$175
Updated
2021/12/16
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2-[2-(2-methoxyethoxy)ethoxy]ethylamine Chemical Properties,Usage,Production

Description

m-PEG3-amine is a PEG reagent containing an amino group (NH2). The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG3-amine whose chemical name 2-[2-(2-methoxyethoxy)ethoxy]ethylamine,it is a PROTAC bridge, belonging to the PEG class, which can be used to synthesize a series of PROTAC molecules, and can also be used for the synthesis of antibody drug conjugates (ADCs).

Synthesis

2-[2-(2-methoxyethoxy)ethoxy]ethylamine is an organic intermediate, which can be prepared from triethylene glycol monomethyl ether as raw material to prepare 2-(2-(2-methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate, and then Reaction with sodium azide,and then Reacts with sodium azide to finally yield 3,6,9-trioxa-1-aminodecane.

IC 50

Cleavable Linker; PEGs

References

[1] Patent: WO2015/191433, 2015, A1. Location in patent: Paragraph 0041
[2] Chemische Berichte, 1980, vol. 113, # 5, p. 1691 - 1707
[3] Molecules, 2015, vol. 20, # 9, p. 16085 - 16102
[4] Chemistry - An Asian Journal, 2011, vol. 6, # 1, p. 149 - 156
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 48, p. 15461 - 15465

2-[2-(2-methoxyethoxy)ethoxy]ethylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-(2-methoxyethoxy)ethoxy]ethylamine Suppliers

China 153 Germany 1 India 2 United Kingdom 1 United States 13 Global 170
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 2-[2-(2-methoxyethoxy)ethoxy]ethylamine manufacturers

LAURENT
Product
mPEG3-NH2 74654-07-2
Price
US $4560.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
300kg
Release date
2025-11-20
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
m-PEG3-Amine 74654-07-2
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-06
Xian confluore Biological Technology Co., Ltd.
Product
m-PEG3-amine 74654-07-2
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-03-27

74654-07-2, 2-[2-(2-methoxyethoxy)ethoxy]ethylamineRelated Search:

OCTAETHYLENE GLYCOL MONOMETHYL ETHER Methyl-PEG3-MS Methyl-PEG9-t-butyl ester 1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane Nonaethylene glycol HEXAETHYLENE GLYCOL MONOMETHYL ETHER BIOTIN-XX-NHS H2N-PEG24-tBu 2,5,8,11,14,17,20-Heptaoxadocosane-22-thiol Boc-1-amino-3,6-dioxa-8-octanediamine 2-(2-Methoxyethoxy)ethanamine alpha, oMega-Dipropionic acid triethylene glycol HS-PEG8-CH2CH2COOH 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane-28-thiol DODECAETHYLENE GLYCOL alpha-aMine-oMega-propionic acid octaethylene glycol N3-PEG6-tBu Amino-PEG2-acid

  • 2-[2-(2-methoxyethoxy)ethoxy]ethylamine
  • 2-[2-(2-Methoxyethoxy)ethoxy]ethanamine
  • 3,6,9-Trioxadecane-1-amine
  • 2,5,8-trioxatridecane-10-aMine
  • MPEG3-NH2
  • EthanaMine,2-[2-(2-Methoxyethoxy)ethoxy]-
  • 3,6,9-Trioxa-1-aminodecane
  • Methyl-PEG3-amine
  • m-PEG3-Amine
  • NH3-PEG3-OME
  • 2-(2-(2-Methoxyethoxy)ethoxy) ethanamine >=95%
  • MeO-PEG3-NH2
  • 2-(2-(2-Methoxyethoxy)ethoxy)-eth
  • 2-(2-(2-methoxyethoxy)ethoxy)ethan-1-amine
  • H2N-(CH2CH2O)3-Me
  • mPEG3-NH2/Ethanamine, 2-[2-(2-methoxyethoxy)ethoxy]-
  • 74654-07-2
  • MeO-PEG-NH2
  • peg