Cediranib

ChemicalBook > CAS DataBase List > Cediranib

Anticancer drugs

Product Name: Cediranib
CAS No.: 288383-20-0
Chemical Name: Cediranib
Synonyms: CS-377;AZD2171;Recentin;Cediranib;Cadiranib;NSC-732208;Cediranib R;Cediranib, >=99%;Cediranib (AZD217);Cediranib(AZD2171)
CBNumber: CB3947063
Molecular Formula: C25H27FN4O3
Formula Weight: 450.51
MOL File: 288383-20-0.mol

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Cediranib Property

Melting point:: 135-138°C
Boiling point:: 626.6±55.0 °C(Predicted)
Density: 1.285
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 16.14±0.30(Predicted)
color: White to Off-White

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11495
Product name: Cediranib
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 11495
Product name: Cediranib
Purity: ≥98%
Packaging: 10mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 11495
Product name: Cediranib
Purity: ≥98%
Packaging: 25mg
Price: $289
Updated: 2024/03/01

TRC

Product number: C231355
Product name: Cediranib
Packaging: 100mg
Price: $520
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000551
Product name: CEDIRANIB
Purity: 95.00%
Packaging: 5MG
Price: $530
Updated: 2021/12/16

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Cediranib Chemical Properties,Usage,Production

Anticancer drugs

Cediranib is an oral anticancer drug , it is successfully developed by the US AstraZeneca company , its trade name is recentin, this product is an efficient VEGFR tyrosine kinase inhibitor, it is capable of inhibiting all known VEGFR tyrosine kinases ( including VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR). Cediranib can inhibit VEGF-induced angiogenesis, neovascularization survival and human tumor xenograft cell growth.Clinical trail phase I for non-small cell lung cancer (abbreviated NSCLC) patients shows that cediranib in combination with PC programs has a significant antitumor effect . Clinical trail phaseⅡ/Ⅲ BR24 focuses on using cediranib 30mg as a first-line treatment of NSCLC ,which demonstrates that it has anti-tumor effect, but it has a higher incidence of adverse events, including diarrhea, dehydration, hand-foot syndrome, hypertension and neutropenia disease. Therefore, there is the decision to stop clinical trials. Repeated assessments about toxicity and dose of the combination of drugs suggest that part of the adverse effects are dose-related , dose reduction may be tried to improve drug tolerance. In view of this conclusion, in 2009, the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) launched a cediranib clinical trail phase Ⅲ (BR29) for progressive NSCLC patients , the dose was adjusted to 20mg. The results have not been reported.
In 2009 ,European Society for Medical Oncology (ESMO) Annual report which is about cediranib treatment of metastatic renal cell carcinoma (referred mRCC) clinical trail phase II shows that cediranib treatment group tumor volume reducing rate is higher than the placebo group. Zurita tested Cediranib pretreatment serum cytokines and angiogenic factors ,and found that patients having low IL-10, VEGF, PIGF, SCF and MIG concentration during baseline time , have the more obvious tumor volume reduction after treatment.
The above information is edited by the chemicalbook of Tian Ye.

Description

Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy. Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC₅₀s = 5, 1, and 3 nM, respectively). It also potently inhibits a variety of other receptor and non-receptor tyrosine kinases, including several in the platelet-derived growth factor, fibroblast growth factor, and endothelial growth factor receptor families. Cediranib blocks tubule formation by human umbilical vein endothelial cells in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo. Because of these effects, cediranib has potential use in a range of cancers.

Uses

Cediranib (AZD2171) inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively.

Uses

Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.

Definition

ChEBI: 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline is an aromatic ether.

storage

Store at -20°C

References

[1] wedge sr, kendrew j, hennequin lf, valentine pj, barry st, brave sr, smith nr, james nh, dukes m, curwen jo, chester r, jackson ja, boffey sj, kilburn ll, barnett s, richmond gh, wadsworth pf, walker m, bigley al, taylor st, cooper l, beck s, jürgensmeier jm, ogilvie dj. azd2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. cancer res. 2005 may 15;65(10):4389-400.

Cediranib Preparation Products And Raw materials

Raw materials

Preparation Products

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Cediranib Suppliers

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View Lastest Price from Cediranib manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Cediranib 288383-20-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500ton
Release date: 2021-08-12

Hebei Mojin Biotechnology Co., Ltd

Product: Cediranib 288383-20-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-06

Hebei Guanlang Biotechnology Co., Ltd.

Product: Cediranib 288383-20-0
Price: US $10.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-03-12

288383-20-0, CediranibRelated Search:

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Cediranib

4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline

Cadiranib (AZD2171)

Cediranib(AZD2171)

AZD2171

Recentin

Cadiranib

Cediranib R

4-((4-fluoro-2-Methyl-1H-indol-5-yl)oxy)-6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

Cediranib (AZD217)

Cediranib dihydrochloride

(557795-03-6) cediranib

RECENTIN;AZD2171;AZD 2171;AZD-2171

NSC-732208

4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline Cediranib (AZD2171)

Cediranib 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline

Cediranib, >=99%

CS-377

Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-

Cediranib (free base)

Cediranib USP/EP/BP

Cediranib (NSC-732208

288383-20-0 Cediranib

AZD2171, Cediranib

Carprofen Impurity 8(Carprofen EP Impurity H )

288383-20-0

C25H27FN4O3

Inhibitors

Antineoplastic

APIs

288383-20-0