4-Fluoro-5-hydroxy-2-methylindole
- Product Name
- 4-Fluoro-5-hydroxy-2-methylindole
- CAS No.
- 288385-88-6
- Chemical Name
- 4-Fluoro-5-hydroxy-2-methylindole
- Synonyms
- CEDI-006;4-FLUORO-5-HYDROXY-2-ME;4-FLUORO-2-METHYL-1H-INDOL-5-OL;4-Fluoro-5-hydroxy-2-methylindol;1H-Indol-5-ol, 4-fluoro-2-Methyl-;4-FLUORO-5-HYDROXY-2-METHYLINDOLE;2-Methyl-4-fluoro-5-hydroxyindole;4-Fluoro-5-hydroxy-2-methylindoleor;4-Fluoro-5-hydroxy-2-methyl-1H-indole;Cediranib 4-Fluoro 5-Hydroxy 2-Methylindole
- CBNumber
- CB5685068
- Molecular Formula
- C9H8FNO
- Formula Weight
- 165.16
- MOL File
- 288385-88-6.mol
4-Fluoro-5-hydroxy-2-methylindole Property
- Boiling point:
- 327.3±37.0 °C(Predicted)
- Density
- 1.367
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 7.39±0.50(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C9H8FNO/c1-5-4-6-7(11-5)2-3-8(12)9(6)10/h2-4,11-12H,1H3
- InChIKey
- UMWRMOYYUHIPDT-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(F)=C(O)C=C2)C=C1C
- CAS DataBase Reference
- 288385-88-6(CAS DataBase Reference)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC908657
- Product name
- 4-Fluoro-5-hydroxy-2-methylindole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- X7167
- Product name
- 4-Fluoro-5-hydroxy-2-methylindole
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- PC908657
- Product name
- 4-Fluoro-5-hydroxy-2-methylindole
- Purity
- 95%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- HCH0013234
- Product name
- 4-FLUORO-5-HYDROXY-2-METHYLINDOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $297.15
- Updated
- 2021/12/16
- Product number
- 122442
- Product name
- 4-Fluoro-5-hydroxy-2-methylindole
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $380
- Updated
- 2021/12/16
4-Fluoro-5-hydroxy-2-methylindole Chemical Properties,Usage,Production
Synthesis
288385-98-8
288385-88-6
The general procedure for the synthesis of 4-fluoro-5-hydroxy-2-methylindole from 2-acetylmethylene-3-fluoro-4-benzyloxynitrobenzene was as follows: 3-acetylmethyl-1-benzyloxy-2-fluoro-4-nitrobenzene (300 mg, 0.99 mmol) was dissolved in ethanol (10 mL) and acetic acid (1 mL) containing 10% palladium charcoal (30 mg), and the reaction was carried out at 50 °C in a 2 atmosphere of hydrogen at 2 atmospheres for 2 hours. Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was subsequently evaporated to remove the solvent. The residue was dissolved in ethyl acetate and the organic phase was washed sequentially with aqueous sodium bicarbonate and saturated saline, followed by evaporation of the solvent to afford the crude product 4-fluoro-5-hydroxy-2-methylindole. The crude product was purified by column chromatography using ethyl acetate/petroleum ether (3:7, v/v) as eluent to finally obtain purified 4-fluoro-5-hydroxy-2-methylindole (63 mg, 30% yield). Mass spectrum (MS-ESI): m/z 166 [M+H]+. 1H NMR (DMSO-d6, δ): 2.35 (s, 3H), 6.05 (s, 1H), 6.65 (dd, 1H), 6.9 (d, 1H), 8.75 (s, 1H), 10.9 (s, 1H). 13C NMR (DMSO-d6, δ). 94.0, 106.0, 112.0, 118.5 (d), 132.0 (d), 136.0 (d), 136.5, 142.5 (d).
References
[1] Patent: WO2004/9542, 2004, A2. Location in patent: Page 36
[2] Patent: US2003/207878, 2003, A1
[3] Patent: US2003/212055, 2003, A1
4-Fluoro-5-hydroxy-2-methylindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-5-hydroxy-2-methylindole manufacturers
- Product
- 4-Fluoro-5-hydroxy-2-methylindole 288385-88-6
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-19
- Product
- 4-Fluoro-5-hydroxy-2-methylindole 288385-88-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 4-Fluoro-5-hydroxy-2-methylindole 288385-88-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2020-07-17