ChemicalBook > CAS DataBase List > 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid

6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid

Product Name: 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
CAS No.: 133081-25-1
Chemical Name: 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid
Synonyms: 6-Boc-Hynic;4-HYDROXYETHANESULPHONICACID;6-Boc-hydrazinonicotinic acid;6-Boc-Hydrazynonicotinic acid;6-(2-Boc-hydrazino)nicotinic Acid;Butoxycarbonyl)hydrazinyl]nicotinic acid;6-(1-(tert-butoxycarbonyl)hydrazinyl)nicotinic acid;6-(2-(TERT-BUTOXYCARBONYL)HYDRAZINYL)NICOTINIC ACID;6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid USP/EP/BP;6-({[(tert-butoxy)carbonyl]aMino}aMino)pyridine-3-carboxylic acid
CBNumber: CB3947412
Molecular Formula: C11H15N3O4
Formula Weight: 253.25
MOL File: 133081-25-1.mol

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6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid Property

Melting point:: 126 °C
Density: 1.312
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.61±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B943415
Product name: 6-Boc-Hynic
Packaging: 500mg
Price: $315
Updated: 2021/12/16

ChemScene

Product number: CS-W005082
Product name: 6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinicacid
Purity: 97.99%
Packaging: 1g
Price: $118
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005006
Product name: BOC-HYNIC
Purity: 95.00%
Packaging: 0.25G
Price: $244
Updated: 2021/12/16

AK Scientific

Product number: X9847
Product name: 6-Boc-Hydrazynonicotinicacid
Packaging: 1g
Price: $276
Updated: 2021/12/16

Ark Pharm

Product number: AK-28763
Product name: 6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinicacid
Purity: 95+%
Packaging: 5g
Price: $294
Updated: 2021/12/16

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6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid Chemical Properties,Usage,Production

Uses

6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

133081-24-0

24424-99-5

133081-25-1

Di-tert-butyl dicarbonate (0.40 g, 1.82 mmol) was added to an N,N-dimethylformamide (DMF) solution of 6-hydrazinylpyridine-3-carboxylic acid (0.346 g, 1.82 mmol) and triethylamine (0.32 mL, 2.36 mmol). The reaction mixture was stirred at 25 °C for 1 h to become homogeneous, and stirring was continued for 16 h. The reaction was carried out under reduced pressure. After completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with a solvent mixture of ethyl acetate/methanol (4:1, v/v) and purified by silica gel column chromatography, using ethyl acetate as eluent, to afford 6-[2-(tert-butoxycarbonyl)hydrazinyl]nicotinic acid (4b) as a light yellow solid (0.44 g, 96% yield).IR (ATR, cm-1): 3353, 3227, 2975, 1719, 1593, 1472, 1372, 1256, 1014, 867, 794, 520. 1H NMR (DMSO-d6, δ): 12.584 (s, 1H), 8.59 (s, 1H), 7.97 (d, J = 9 Hz, 1H), 6.54 (d, J = 9 Hz, 1H). 13C NMR (DMSO-d6, δ): 166.6 , 155.7, 150.5, 138.5, 116.7, 79.3, 28.1, 14.0. MS (ESI-): [M-H]- m/z 252.00. MS (ESI+): [M+H]+ m/z 254.07. HRMS (ESI+): [M+H]+ m/z 254.1145 (calculated values) C11H16N3O4, 254.1141).

References

[1] Letters in Organic Chemistry, 2014, vol. 11, # 3, p. 208 - 214
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4764 - 4767
[3] Polish Journal of Chemistry, 2004, vol. 78, # 7, p. 951 - 959
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2018, vol. 61, # 2, p. 68 - 76
[5] Pharmazie, 2006, vol. 61, # 4, p. 269 - 273

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View Lastest Price from 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid manufacturers

Career Henan Chemical Co

Product: 6-[2-(tert-Butoxycarbonyl)hydrazinyl]nicotinic acid 133081-25-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

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133081-25-1