ChemicalBook > CAS DataBase List > 1-Boc-3-iodoazetidine

1-Boc-3-iodoazetidine

Product Name: 1-Boc-3-iodoazetidine
CAS No.: 254454-54-1
Chemical Name: 1-Boc-3-iodoazetidine
Synonyms: tert-butyl 3-iodoazetidine-1-carboxylate;N-Boc-3-iodoazetidine;Boc-3-iodoazetidine;1-Boc-3-iodoazetidin;1-Boc-3-iodo-azetidine;1-N-Boc-3-iodoazetidine;1-Boc-3-iodoazetidine,97%;1-BOC-3-IODO-AZETIDINE 98%;1-BOC-3-Iodoazetidine - [B3079];3-Iodoazetidine, N-BOC protected
CBNumber: CB3947472
Molecular Formula: C8H14INO2
Formula Weight: 283.11
MOL File: 254454-54-1.mol

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1-Boc-3-iodoazetidine Property

Boiling point:: 282.0±33.0 °C(Predicted)
Density: 1.63g/ml
refractive index: 1.5090 to 1.5130
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
pka: -3.39±0.40(Predicted)
color: Colorless to Brown
Sensitive: Light Sensitive
InChI: InChI=1S/C8H14INO2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5H2,1-3H3
InChIKey: XPDIKRMPZNLBAC-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(I)C1
CAS DataBase Reference: 254454-54-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,T
Risk Statements: 25-36-50
Safety Statements: 26-45
RIDADR: UN 3082 9 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00134
Product name: 1-Boc-3-Iodoazetidine
Purity: Aldrich
Packaging: 1g
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: B4288
Product name: 1-(tert-Butoxycarbonyl)-3-iodoazetidine
Purity: >95.0%(GC)
Packaging: 1g
Price: $35
Updated: 2025/07/31

TCI Chemical

Product number: B4288
Product name: 1-(tert-Butoxycarbonyl)-3-iodoazetidine
Purity: >95.0%(GC)
Packaging: 5g
Price: $101
Updated: 2025/07/31

TRC

Product number: B656680
Product name: N-Boc-3-iodoazetidine
Packaging: 5g
Price: $90
Updated: 2021/12/16

Synthonix

Product number: B3079
Product name: 1-BOC-3-Iodoazetidine
Purity: 97.0%
Packaging: 50g
Price: $90
Updated: 2021/12/16

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1-Boc-3-iodoazetidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to red-brown liquid

Uses

1-Boc-3-iodoazetidine is used as an organic chemical synthesis intermediate.

Synthesis

141699-55-0

254454-54-1

The general procedure for the synthesis of 1-Boc-3-iodoazetidine from N-Boc-3-hydroxyazetidine is as follows: Step B: Synthesis of tert-butyl 3-iodoazetidine-1-carboxylate. To a solution of tert-butyl 3-hydroxyazetidine-1-carboxylate (3.35 g, 19.3 mmol) in toluene (200 mL) was sequentially added imidazole (3.95 g, 58.0 mmol), triphenylphosphine (10.1 g, 38.7 mmol) and iodine (7.36 g, 29.0 mmol). The reaction mixture was heated at 100 °C for 1 h, subsequently cooled to room temperature and poured into aqueous sodium bicarbonate solution (30 mL). Iodine was added to quench the excess triphenylphosphine until the iodine color in the organic layer disappeared. The organic layer was separated, washed with saturated aqueous sodium thiosulfate and dried over anhydrous sodium sulfate. The crude product was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate = 9:1 to 1:1) to afford 1-Boc-3-iodoazetidine (5.42 g, 99% yield) as a clear oil. MS (ESI) m/z 284 (M + 1)+.

References

[1] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 47
[2] Patent: WO2006/40182, 2006, A1. Location in patent: Page/Page column 132-133
[3] Patent: WO2008/116831, 2008, A1. Location in patent: Page/Page column 37
[4] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 287; 288
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0805; 0806

1-Boc-3-iodoazetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Boc-3-iodoazetidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Boc-3-iodoazetidine 254454-54-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Henan Fengda Chemical Co., Ltd

Product: 1-Boc-3-iodoazetidine 254454-54-1
Price: US $6.00-0.20/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-28

Career Henan Chemical Co

Product: 1-Boc-3-iodoazetidine 254454-54-1
Price: US $1.00/IU
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-27

254454-54-1, 1-Boc-3-iodoazetidineRelated Search:

Boc-Beta-iodo-Ala-Ome 1-BOC-3-(METHOXY)AZETIDINE 1-BOC-3-METHYL-PIPERIDIN-4-ONE N-1-Boc-3-phenylpiperazine 3-Oxetanone 1-Boc-3-piperidone 1-Boc-3-Hydroxypyrrolidine 1-Boc-3-(Amino)azetidine 1-N-Boc-3-hydroxyazetidine TRIMETHYLENE OXIDE ISOBUTANE Azetidine n-Butane 1-Chloro-2-methylpropane tert-Butyl carbazate DI-TERT-BUTYL ETHER 1-Boc-3-iodoazetidine

1-BOC-3-IODO-AZETIDINE 98%

tert-butyl 3-iodoazetidine-1-carboxylate

3-Iodoazetidine, N-BOC protected 97%

N-Boc-3-iodoazetidine

3-Iodoazetidine, N-BOC protected

1-N-Boc-3-iodoazetidine

1-Boc-3-iodo-azetidine

1-tert-Butoxycarbonyl-3-iodoazetidine

tert-Butyl 3-iodoazetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-iodoazetidine

1-(tert-Butoxycarbonyl)-3-iodoazetidine &gt

1-Azetidinecarboxylic acid, 3-iodo-, 1,1-dimethylethyl ester

1-Boc-3-iodoazetidine,97%

Boc-3-iodoazetidine

ert-butyl3-iodoazetidine-1-carboxylate

2-Methyl-2-propanyl 3-iodo-1-azetidinecarboxylate

1-BOC-3-Iodoazetidine - [B3079]

1-Boc-3-iodoazetidin

254454-54-1

C8H14INO2

Azetidine