2-Chloro-5-methylpyrimidine
- Product Name
- 2-Chloro-5-methylpyrimidine
- CAS No.
- 22536-61-4
- Chemical Name
- 2-Chloro-5-methylpyrimidine
- Synonyms
- 2-Chlor5-Methyl pyrimidine;2-Chloro-5-methylpyrimidine;2-Chloro-5-methyl-1,3-diazine;Pyrimidine, 2-chloro-5-methyl-;2-Chloro-5-methylpyrimidine >2-Chloro-5-methylpyrimidine 98%;2-Chloro-5-MethylpyriMidine, 97+%;Pyrimidine, 2-chloro-5-methyl- (8CI,9CI);2-Chloro-5-methylpyrimidine ISO 9001：2015 REACH
- CBNumber
- CB3967342
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 22536-61-4.mol
2-Chloro-5-methylpyrimidine Property
- Melting point:
- 89-92℃
- Boiling point:
- 239.2±9.0 °C(Predicted)
- Density
- 1.234±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.03±0.22(Predicted)
- form
- Solid
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C5H5ClN2/c1-4-2-7-5(6)8-3-4/h2-3H,1H3
- InChIKey
- APRMCBSTMFKLEI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(C)C=N1
- CAS DataBase Reference
- 22536-61-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2957
- Product name
- 2-Chloro-5-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- C2957
- Product name
- 2-Chloro-5-methylpyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $161
- Updated
- 2025/07/31
- Product number
- C368633
- Product name
- 2-Chloro-5-methylpyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C368633
- Product name
- 2-Chloro-5-methylpyrimidine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR46244
- Product name
- 2-Chloro-5-methylpyrimidine
- Purity
- 98%
- Packaging
- 25g
- Price
- $86
- Updated
- 2021/12/16
2-Chloro-5-methylpyrimidine Chemical Properties,Usage,Production
Uses
Used in organic synthesis, catalytic agent, petrochemical additive and synthetic chemistry. Also used as intermediate for pharmaceutical.
Synthesis
1780-31-0
22536-61-4
Step 1. Synthesis of 2-chloro-5-methylpyrimidine To a stirred solution of 2,4-dichloro-5-methylpyrimidine (4.00 g, 24.5 mmol) dissolved in a solvent mixture of benzene (16.0 mL) and water (40.0 mL) was added zinc powder (4.81 g, 73.6 mmol) and ammonia (8.80 mL, 24.5 mmol) sequentially at room temperature. The reaction mixture was heated and refluxed for 18 hours, then cooled to room temperature and filtered through a diatomaceous earth pad. The filtrate was extracted with ether (Et2O), and the combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1:1) to afford the target compound 2-chloro-5-methylpyrimidine (2.44 g, 77% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 2.33 (3H, s), 8.47 (2H, s).
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 224
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4720 - 4744
[3] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 8
[4] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 33
[5] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 26-27
2-Chloro-5-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-methylpyrimidine manufacturers
- Product
- 2-Chloro-5-methylpyrimidine 22536-61-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 2-chloro-5-methylpyrimidine 22536-61-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 500kg
- Purity
- 0.98
- Supply Ability
- 20 tons
- Release date
- 2025-03-11
- Product
- 2-Chloro-5-methylpyrimidine 22536-61-4
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-14