ChemicalBook > CAS DataBase List > 2-Chloro-5-methylpyrimidine

2-Chloro-5-methylpyrimidine

Product Name
2-Chloro-5-methylpyrimidine
CAS No.
22536-61-4
Chemical Name
2-Chloro-5-methylpyrimidine
Synonyms
2-Chlor5-Methyl pyrimidine;2-Chloro-5-methylpyrimidine;2-Chloro-5-methyl-1,3-diazine;Pyrimidine, 2-chloro-5-methyl-;2-Chloro-5-methylpyrimidine >2-Chloro-5-methylpyrimidine 98%;2-Chloro-5-MethylpyriMidine, 97+%;Pyrimidine, 2-chloro-5-methyl- (8CI,9CI);2-Chloro-5-methylpyrimidine ISO 9001：2015 REACH
CBNumber
CB3967342
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
22536-61-4.mol
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2-Chloro-5-methylpyrimidine Property

Melting point:
89-92℃
Boiling point:
239.2±9.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-1.03±0.22(Predicted)
form 
Solid
color 
White to Light yellow
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C5H5ClN2/c1-4-2-7-5(6)8-3-4/h2-3H,1H3
InChIKey
APRMCBSTMFKLEI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(C)C=N1
CAS DataBase Reference
22536-61-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2957
Product name
2-Chloro-5-methylpyrimidine
Purity
>98.0%(GC)
Packaging
1g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
C2957
Product name
2-Chloro-5-methylpyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$161
Updated
2025/07/31
TRC
Product number
C368633
Product name
2-Chloro-5-methylpyrimidine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C368633
Product name
2-Chloro-5-methylpyrimidine
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
070099
Product name
2-Chloro-5-methylpyrimidine
Purity
97%
Packaging
5g
Price
$19
Updated
2021/12/16
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2-Chloro-5-methylpyrimidine Chemical Properties,Usage,Production

Uses

Used in organic synthesis, catalytic agent, petrochemical additive and synthetic chemistry. Also used as intermediate for pharmaceutical.

Synthesis

1780-31-0

22536-61-4

Step 1. Synthesis of 2-chloro-5-methylpyrimidine To a stirred solution of 2,4-dichloro-5-methylpyrimidine (4.00 g, 24.5 mmol) dissolved in a solvent mixture of benzene (16.0 mL) and water (40.0 mL) was added zinc powder (4.81 g, 73.6 mmol) and ammonia (8.80 mL, 24.5 mmol) sequentially at room temperature. The reaction mixture was heated and refluxed for 18 hours, then cooled to room temperature and filtered through a diatomaceous earth pad. The filtrate was extracted with ether (Et2O), and the combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 1:1) to afford the target compound 2-chloro-5-methylpyrimidine (2.44 g, 77% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 2.33 (3H, s), 8.47 (2H, s).

References

[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 224
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4720 - 4744
[3] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 8
[4] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 33
[5] Patent: US2008/306082, 2008, A1. Location in patent: Page/Page column 26-27

2-Chloro-5-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-methylpyrimidine Suppliers

Americas 1 CHINA 197 Europe 2 Germany 1 India 5 Japan 1 Switzerland 1 United Kingdom 5 United States 27 Global 240
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View Lastest Price from 2-Chloro-5-methylpyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-5-methylpyrimidine 22536-61-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-06-04
Jiangsu Liyang Kunlun Biological Technology Co., Ltd.
Product
2-chloro-5-methylpyrimidine 22536-61-4
Price
US $0.00-0.00/kg
Min. Order
500kg
Purity
0.98
Supply Ability
20 tons
Release date
2025-03-11
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-5-methylpyrimidine 22536-61-4
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-14

22536-61-4, 2-Chloro-5-methylpyrimidineRelated Search:

4-(Chloromethyl)benzoic acid Pirimiphos-methyl 2-Chloro-5-nitropyrimidine 2-Chloropyrimidine tert-Butyldimethylsilyl chloride Sulfamerazine Chloromethane 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBONYL CHLORIDE 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE Difluorochloromethane 2,4,6-Trichloro-5-methylpyrimidine 2-Chloro-5-ethylpyrimidine Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 2-Chloro-5-propylpyrimidine 2,4-Dichloro-5-methylpyrimidine 5-Amino-4,6-dichloro-2-methylpyrimidine 2-CHLORO-4-METHYLPYRIMIDINE 98%,2-CHLORO-4-METHYLPYRIMIDINE 4,6-Dichloro-5-methylpyrimidine

  • 2-Chloro-5-methylpyrimidine
  • Pyrimidine, 2-chloro-5-methyl- (8CI,9CI)
  • 2-Chloro-5-methyl-1,3-diazine
  • 2-Chloro-5-MethylpyriMidine, 97+%
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  • 2-Chloro-5-methylpyrimidine 98%
  • 2-Chloro-5-methylpyrimidine &gt
  • Pyrimidine, 2-chloro-5-methyl-
  • 2-Chloro-5-methylpyrimidine ISO 9001：2015 REACH
  • 22536-61-4
  • 13036-57-3
  • Heterocycle-Pyrimidine series
  • PYRIMIDINE
  • pharmacetical
  • Pyrimidine series