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Esculentoside A

Product Name
Esculentoside A
CAS No.
65497-07-6
Chemical Name
Esculentoside A
Synonyms
Esculentoside;ESCULENTOSIDE A;Esculentoside A-RM;Phytolaccasaponin E;Esculentoside A USP/EP/BP;Esculentoside A, 10 mM in DMSO;Phytolaccasaponin E in methanol;Esculentoside A, 98%, from Phytolacca acinosa Roxb.;(2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester;Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)-
CBNumber
CB3983421
Molecular Formula
C42H66O16
Formula Weight
826.96
MOL File
65497-07-6.mol
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Esculentoside A Property

Melting point:
>192°C (dec.)
Boiling point:
936.7±65.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.39±0.70(Predicted)
form 
Solid
color 
Pale Yellow
Stability:
Hygroscopic
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Safety

Safety Statements 
24/25
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
300241
Product name
Esculentoside A
Packaging
20mg
Price
$390
Updated
2021/12/16
Usbiological
Product number
296973
Product name
Esculentoside A
Packaging
10mg
Price
$470
Updated
2021/12/16
TRC
Product number
E658875
Product name
EsculentosideA
Packaging
100mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-0009623
Product name
EsculentosideA
Purity
98.27%
Packaging
5mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
OE33280
Product name
Esculentoside A
Packaging
5mg
Price
$90
Updated
2021/12/16
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Esculentoside A Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in water, hot methanol and ethanol, n-butanol, insoluble in acetone, ether and other lipophilic solvents, from the commercial land Phytolacca acinosa Roxb.

Uses

Esculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500

Pharmacokinetics

Esculentoside A is a triterpenoid saponin isolated from the root of Phytolacca esculenta. Studies have revealed that this triterpenoid exhibits a strong anti-inflammatory property. Ci et al. (2015) observed the anti-inflammatory potency of esculentoside A against allergic airway inflammation in a mouse model. They found that the drug enhanced nuclear Nrf-2 translocation in the lungs of ovalbumin-challenged mice and also decreased airway inflammation (Ci et al., 2015). Esculentoside A enhanced the intracellular anti-oxidant potentials, reduced Th2 cytokine level and down-regulated the expression of adhesion molecule mRNA in lung tissues. Zhang et al. (2014) found that esculentoside A could rectify carbon tetrachlorideinduced acute liver injury in mice. The drug successfully cured the histopathological damage induced by carbon tetrachloride. Rectification has been also noted through the down-regulation of inflammatory molecules and oxidative stresses associated with PPAR-γ, NF-κB and ERK signal pathways (Zhang et al., 2014). Ma et al. (2013) analyzed the role of esculentoside A on lupus nephritis-induced BXSB mice (where male SB/Le mice and female C57BL/6 mice were hybridized, creating a recombinant inbred species). They observed that esculentoside A application significantly reduced urine protein excretion and improved renal function by promoting apoptosis of glomerular intrinsic cells and renal tubular epithelial cells (Ma et al., 2013). The efficacy was also aided by the down-regulation of inflammatory cytokines.
Wang et al. (2016) elucidated the role of esculentoside A against acetaminophen-induced liver toxicity in mice and observed that Nrf2-regulated the survival mechanism via the AMPK/ Akt/GSK3β pathway.

in vivo

Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis[2].? Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge[4].

Animal Model: BXSB mice[2]
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks
Result: Alleviated the renal damage of LN.

Esculentoside A Preparation Products And Raw materials

Raw materials

Preparation Products

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Esculentoside A Suppliers

China 192 Germany 1 India 1 United Kingdom 2 United States 15 USA 1 Global 212
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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61
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
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57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
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57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
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58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Fax
QQ：190129269
Email
winherb@126.com
Country
China
ProdList
1245
Advantage
58
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View Lastest Price from Esculentoside A manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Esculentoside A 65497-07-6
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-29
Career Henan Chemical Co
Product
Esculentoside A 65497-07-6
Price
US $1.00/kg
Min. Order
1 mg
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

65497-07-6, Esculentoside ARelated Search:

POKEWEED MITOGEN Escin Ginsenoside Rh2 TRIBULOSIDE Saponin Ginsenoside Rb1 Phytolaccagenin esculentoside H Ginsenosides Escin sodium trans-4-Hexylcyclohexanecarboxylic acid DIETHYLMALONIC ACID trans-4-Ethylcyclohexanecarboxylic acid METHYL 15-METHYLHEPTADECANOATE trans-4-Propylcyclohexanecarboxylic acid Butylmalonic acid 2,2-Dipropylmalonic acid beta-Amyrin

  • ESCULENTOSIDE A
  • Esculentoside
  • (2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester
  • Phytolaccasaponin E
  • Esculentoside A, 98%, from Phytolacca acinosa Roxb.
  • Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)-
  • Esculentoside A USP/EP/BP
  • (2S,4aR,6aS,6bR,8aR,9R,10R,11S,12aR,12bR,14bS)-10-(((2S,3R,4R,5R)-3,4-Dihydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-11-hydroxy-9-(hydroxymethyl)-2-(methoxycarbonyl)-2,6a,6b,9,12
  • Phytolaccasaponin E in methanol
  • Esculentoside A-RM
  • Esculentoside A, 10 mM in DMSO
  • 65497-07-6
  • Saponins
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract