Description References
ChemicalBook > CAS DataBase List > Rizatriptan benzoate

Rizatriptan benzoate

Description References
Product Name
Rizatriptan benzoate
CAS No.
145202-66-0
Chemical Name
Rizatriptan benzoate
Synonyms
MAXALT;MK-462;MK-0462;Rizatrimptan;MK-462 Benzoate;Rizatriptan API;Rizatriptan Benzoat;RIZATRIPTAN BENZOATE;Rizatriptani benzoas;Rizatrimptan Benzoate
CBNumber
CB4100441
Molecular Formula
C22H25N5O2
Formula Weight
391.48
MOL File
145202-66-0.mol
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Rizatriptan benzoate Property

Melting point:
178-180°C
storage temp. 
2-8°C
solubility 
H2O: ≥5mg/mL
form 
powder
color 
white to beige
Merck 
14,8241
InChIKey
JPRXYLQNJJVCMZ-UHFFFAOYSA-N
CAS DataBase Reference
145202-66-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
61
WGK Germany 
3
HS Code 
2933995500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0247
Product name
Rizatriptan benzoate salt
Purity
≥98% (HPLC)
Packaging
10mg
Price
$90.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1604880
Product name
Rizatriptan benzoate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$919
Updated
2024/03/01
TCI Chemical
Product number
R0181
Product name
Rizatriptan Benzoate
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$164
Updated
2024/03/01
TCI Chemical
Product number
R0181
Product name
Rizatriptan Benzoate
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$538
Updated
2024/03/01
Cayman Chemical
Product number
16475
Product name
Rizatriptan (benzoate salt)
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
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Rizatriptan benzoate Chemical Properties,Usage,Production

Description

Known as a 5-hydroxytryptamine agonist, Rizatriptan Benzoate is the benzoate salt form of rizatriptan with anti-migraine activity, which can be used to treat the migraine headaches. It is FDA-approved to use in the treatment of acute migraine attacks with or without aura, especially taken at the first sign of a migraine headache. However, it cannot prevent future migraine attacks and it is ineffective to prevent other types of headache.
The pain of migraine headaches is believed to be induced by dilated blood vessels inside the head. Rizatriptan Benzoate relieves the pain by inducing vasoconstriction, which functions as an agonist at serotonin 5-HT1B and 5-HT1D receptors. The selective receptor binding is effective to constrict cranial vessels and inhibit the transmission of nociception, thus providing relief of migraine headaches.

References

https://en.wikipedia.org/wiki/Rizatriptan
https://pubchem.ncbi.nlm.nih.gov/compound/77997#section=Top
http://bodyandhealth.canada.com/drug/getdrug/co-rizatriptan-odt

Description

Rizatriptan was launched for the first time as Maxalt in Mexico for the acute treatment of migraine headaches with or without aura in adults. It is the third in a new generation of triptan migraine drugs to challenge the firstgeneration product Sumatriptan from Glaxo Wellcome, after Zolmitriptan (Zeneca) and Naratriptan (Glaxo Wellcome).
It can be synthetically obtained by two related routes having respectively 3 and 4 steps, both starting from 1 -(4-aminobenzyl)-l,2,4-triazole. Rizatriptan is a full 5-HT1D/1B receptor agonist retaining a significant affinity at 5-HT1A sites (pIC50 = 6.4), with a low affinity for nond-HT sites. It shows craniovascufar selectivity for human isolated middle meningeal over coronary arteries ; its effect on coronary artery constriction is significantly less than that for Sumatriptan. Rizatriptan inhibits the release of neuropeptides that cause swelling of cranial blood vessels. Rizatriptan has a good oral bioavailability (64% and 47% in rats and dogs respectively). and a rapid onset of action : the headache relief in human occurs within 30 to 45 minutes of taking 20 mg. It also relieved nausea and hypersensitivity to noise (phonophobia) and light (photophobia) that are often symptoms accompanying a migraine attack. Among at least 6 metabolites identified in humans after a single oral dose (60 mg), the major urinary metabolite was the corresponding indole-3-acetic acid. Maxalt is available as a novel oral formulation of rapidly dissolving tablets or wafers that does not require liquid for ingestion.

Chemical Properties

Off-White Solid

Originator

Merck & Co (US)

Uses

Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine.

Uses

Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headac

Uses

A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine

Definition

ChEBI: Rizatriptan benzoate is a member of tryptamines.

brand name

Maxalt (Merck).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.

Rizatriptan benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Rizatriptan benzoate Suppliers

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View Lastest Price from Rizatriptan benzoate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Rizatriptan benzoate 145202-66-0
Price
US $0.00-0.00/KG
Min. Order
50g
Purity
99.7%min
Supply Ability
50KG
Release date
2021-06-07
Hebei Dangtong Import and export Co LTD
Product
Rizatriptan benzoate 145202-66-0
Price
US $22.00-20.00/grams
Min. Order
10grams
Purity
99%
Supply Ability
100tons
Release date
2023-02-16
Henan Bao Enluo International TradeCo.，LTD
Product
Rizatriptan benzoate 145202-66-0
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-06-25

145202-66-0, Rizatriptan benzoate Related Search:

5-Methyl-1H-benzotriazole Dacthal Dimethyl sulfoxide Ribavirin Benzyl benzoate 3,5-Dimethylbenzoic acid Dimethyl sulfate Zolmitriptan Dimethyl phthalate 1H-Benzotriazole ETHANE Dimethyl ether Dimethyl carbonate Denatonium Benzoate Anhydrous Rizatriptan Almotriptan 1,2,4-Triazole Sumatriptan

  • RIZATRIPTAN BENZOATE
  • N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE
  • n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate
  • Rizatrimptan Benzoate
  • Rizatrimptan
  • Rizatriptan monobenzoate
  • N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-
  • Acid Bixente triptans
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  • MK-462
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  • Rizatriptan benzoate API
  • MK-462 Benzoate
  • N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine,benzoate (1:1)
  • Rizatriptan benzoate N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate
  • N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt
  • Rizatriptan benzoate salt
  • Rizatriptan for system suitability
  • 2-(5-((1H-1,2,4-triazol-1-yl)Methyl)-1H-indol-3-yl)-N,N-diMethylethanaMine benzoate
  • Rizatriptan Benzoat
  • Rizatriptan (as benzoate)
  • MAXALT
  • RIZATRIPTANE BENZOATE
  • Rizatriptan for system suitability CRS
  • Rizatriptan Benzoate &gt
  • Rizatriptan benzoate CRS
  • Rizatriptan benzoate USP/EP/BP
  • Rizatriptani benzoas
  • Rizatriptan Benzoate (MK-462 Benzoate)
  • Rizatriptan benzoateQ: What is Rizatriptan benzoate Q: What is the CAS Number of Rizatriptan benzoate Q: What is the storage condition of Rizatriptan benzoate Q: What are the applications of Rizatriptan benzoate
  • Rizatriptan Benzoate (1604880)
  • 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1)
  • N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-ethanamine benzoate (1:1)
  • 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethan-1-amine benzoate
  • Rizatriptan API
  • 3-[2-(Dimethylamino) ethyl]- 5- (1,2,4- triazol-1- ylmethyl) -indole benzoate, USP, IP
  • 145202-66-0
  • C15H19N5C7H6O2
  • MK-462, Maxalt
  • Heterocycles
  • API
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
  • Antimigraine
  • Heterocyclic Compounds
  • Rizatriptan
  • Amines