Tulathromycin A

Product Name: Tulathromycin A
CAS No.: 217500-96-4
Chemical Name: Tulathromycin A
Synonyms: CS-2009;Draxxin;CP 472295;Teramycin;Tulamycin;Tulathrmycin A;TULATHROMYCIN A;Unii-897A3kn7ap;Tulathromycin A, >=95%;Tulathromycin isomer mix
CBNumber: CB41011760
Molecular Formula: C41H79N3O12
Formula Weight: 806.09
MOL File: 217500-96-4.mol

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Tulathromycin A Property

Melting point:: 186-188oC
Boiling point:: 853.8±65.0 °C(Predicted)
Density: 1.17
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.19±0.70(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2107
Product name: Tulathromycin A
Purity: ≥95% (HPLC)
Packaging: 10MG
Price: $91.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2107
Product name: Tulathromycin A
Purity: ≥95% (HPLC)
Packaging: 50MG
Price: $371
Updated: 2024/03/01

Cayman Chemical

Product number: 19202
Product name: Tulathromycin A
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19202
Product name: Tulathromycin A
Purity: ≥95%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 19202
Product name: Tulathromycin A
Purity: ≥95%
Packaging: 25mg
Price: $208
Updated: 2024/03/01

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Tulathromycin A Chemical Properties,Usage,Production

Description

Tulathromycin A, marketed as Draxxin by Pfizer Inc., is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers, Tulathromycin A (90%) and B (10%). Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.

Chemical Properties

Tulathromycin is a semi-synthetic macrolide antibiotic of the sub-class triamilide. It occurs as a white to off-white crystalline powder that is readily soluble in water at pH less than 8. At a pH of 7.4 (physiological pH), tulathromycin (a weak base) is 50 times more soluble in hydrophilic than hydrophobic media.

Uses

Tulathromycin A is used for the treatment of pulmonary diseases in pigs and cattle.
In cattle, tulathromycin is used for the treatment of rinderpest caused by Haemolytic rinderpest, polyvalent rinderpest and Haemophilus somnus (formerly Haemophilus somnus). It is also effective in the treatment of infections caused by Mycoplasma bovis. When used in high-risk calves, it is also used to prevent infections caused by these pathogens. It is also used for the treatment of bovine foot rot (interdigital necrotizing fungal disease) associated with Fusarium necrophorum and Fusarium oxysporum. A single dose is effective in bovine infectious keratoconjunctivitis (Mycobacterium bovis).
In pigs, it is used to control and treat SRD associated with Actinobacillus pleuropneumoniae, Bacteroides multilocularis, Bordetella bronchiseptica, Mycoplasma pneumoniae, and Haemophilus parasiticus, and tulathromycin has been used to treat lung abscesses.

Definition

ChEBI:Tulathromycin A is an aminoglycoside.

Biological Activity

Tulathromycin, like other macrolides, exerts therapeutic benefits not solely explainable by antibacterial activity. Like azithromycin, tulathromycin A may have multiple immunomodulatory effects that likely contribute to the therapeutic response in respiratory infections and perhaps other diseases[1]. Other beneficial effects may be caused by enhanced degranulation and apoptosis of neutrophils and inhibition of inflammatory cytokine production. It also may help clear infections by enhancing macrophage functions.

Pharmacokinetics

The half-life is long, with 80- to 90-hour plasma half-life in pigs and cattle, and 8- and 6-day tissue half-life in cattle and pigs, respectively, which prolongs the drug concentration at the site of infection. The volume of distribution is greater than 10 L/kg. Absorption from injection is greater than 80% in cattle and pigs. Tulathromycin A concentrates in bronchoalveolar cells, and concentrations are detectable for at least 8 days after a single administration, although they are still lower than the MIC for R. equi (greater than 64 μg/mL)[1-2].

Mode of action

Tulathromycin A is a macrolide antibiotic. It binds to the subunit 50S of the bacterial ribosome, interfering with bacterial protein synthesis.

References

[1] Mark G, et al. Tulathromycin. Papich Handbook of Veterinary Drugs (Fifth Edition), 2021; 949-951.
[2] Jennifer L, et al. Pharmacologic Principles. Equine Internal Medicine (Fourth Edition), 2018; 79-137.

Tulathromycin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Tulathromycin A Suppliers

Canada 1 China 243 India 3 Japan 1 United Kingdom 2 United States 16 Global 266

MedChemexpress LLC

Tel: 021-58955995
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Musechem

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InvivoChem

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Cckinase, Inc.

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BOC Sciences

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Cato Research Chemicals Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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Tecoland Corporation

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Cayman Chemical Company

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United States Biological

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Synthland Hong Kong Limited

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View Lastest Price from Tulathromycin A manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Tulathromycin 217500-96-4
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-05

Sinoway Industrial co., ltd.

Product: Tulathromycin 217500-96-4
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 95% up, Vet-GMP
Supply Ability: 20tons
Release date: 2024-06-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tulathromycin A 217500-96-4
Price: US $0.00-0.00/KG
Min. Order: 10g
Purity: 96%-102%
Supply Ability: 50KG
Release date: 2021-05-28

217500-96-4, Tulathromycin ARelated Search:

Diclazuril TULATHROMYCIN B,Tulathromycin Bensulfuron methyl Thiophanate-methyl Methylparaben METSULFURON METHYL Azithromycin Methyl acetate Gentamicin Clindamycin Methyl acrylate Kresoxim-methyl Telithromycin Tiamulin Tylosin Tiamulin fumarate Methyl [2H9]-Tulobuterol, racemic mixture

TULATHROMYCIN A

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-a-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Unii-897A3kn7ap

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-Dideoxy-3-C-Methyl-3-O-Methyl-4-C-[(propylaMino)Methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

CP 472295

Draxxin

Tulathromycin A, >=95%

Tulathrmycin A

Tulathromycin A Solution, 1000ppm

Tulathromycin，Tulathromycin A

CS-2009

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one

Tulathromycin isomer mix

pharmaceutical ingredient TULATHROMYCIN A

1-Oxa-6-azacyclopentadecan-15-one, 13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-

Tulathromycin A USP/EP/BP

Tulathromycin A (CP 472295)

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-((propylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one

Teramycin

Tulamycin

Tulathromycin isomer mix in acetonitrile

217500-96-4

C41H79N3O12

API

Carbohydrates & Derivatives

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

217500-96-4