ChemicalBook > CAS DataBase List > 4-(Boc-Aminomethyl)piperidine

4-(Boc-Aminomethyl)piperidine

Product Name: 4-(Boc-Aminomethyl)piperidine
CAS No.: 135632-53-0
Chemical Name: 4-(Boc-Aminomethyl)piperidine
Synonyms: TERT-BUTYL (PIPERIDIN-4-YLMETHYL)CARBAMATE;tert-Butyl N-(piperidin-4-ylmethyl)carbamate;PIP(4-BOC-AM);BUTTPARK 43\57-92;(BOC-4-AMINOMETHYL)PIPERIDINE;4-(BOC-AMINOMETHYL)PIPERIDINE;4-N-BOC-AMINOMETHYL PIPERIDINE;4-(2-BOC-AMINOMETHYL) PIPERIDINE;me: 4-(Boc-Aminomethyl)piperidine;4-(Boc-aminomethyl)piperidine,97%
CBNumber: CB4102632
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 135632-53-0.mol

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4-(Boc-Aminomethyl)piperidine Property

Melting point:: 106 °C
Boiling point:: 321.8±15.0 °C(Predicted)
Density: 0.981±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in DMSO.
pka: 12.72±0.46(Predicted)
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 135632-53-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/38
Safety Statements: 26-36/37/39-45
RIDADR: 3259
Hazard Note: Corrosive
HazardClass: IRRITANT
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4444
Product name: 4-(tert-Butoxycarbonylaminomethyl)piperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $344
Updated: 2025/07/31

TRC

Product number: B701450
Product name: tert-Butyl(Piperidin-4-ylmethyl)carbamate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 016373
Product name: tert-Butyl (piperidin-4-ylmethyl)carbamate
Purity: 95+%
Packaging: 5g
Price: $48
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB36900
Product name: 4-(N-Boc-aminomethyl)piperidine
Packaging: 2g
Price: $50
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK989088
Product name: 4-(Boc-aminomethyl)piperidine
Purity: 97%
Packaging: 1g
Price: $67
Updated: 2021/12/16

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4-(Boc-Aminomethyl)piperidine Chemical Properties,Usage,Production

Chemical Properties

4-Boc-aminomethylpiperidine contains a piperidine ring and an aminomethyl group, and the aminomethyl group is protected by a tert-butoxycarbonyl (Boc) group. This compound is commonly used as an intermediate in organic synthesis. The Boc protecting group is a common protecting group that protects the amine group in organic synthesis reactions. By adding the Boc protecting group, the amine group can be prevented from unwanted reactions while allowing other chemical reactions to take place. The tert-butoxycarbonyl protecting group can be removed under appropriate conditions before the amine group needs to be reduced.

Uses

4-(Boc-aminomethyl)piperidine is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

7144-05-0

49761-82-2

135632-53-0

General procedure: 4-aminomethylpiperidine (3.6 g) and 1-BOC-imidazole (5.3 g) were dissolved in toluene (80 mL), and the reaction was stirred at 25°C overnight. After completion of the reaction, the solution was concentrated and the residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/2) to afford Intermediate 227-I (4.7 g) in 70% yield. Intermediate 227-I (4.7 g) and triethylamine (2.7 mL) were dissolved in 1-pentanol (20 mL), 2,4-dichloro-6-aminopyrimidine (5.4 g) was added, and the reaction was carried out at 120 °C for 12 hours. After completion of the reaction, the solvent was removed and the residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/9) to afford Intermediate 227-II (5.2 g) in 70% yield. Intermediate 227-II (1.0 g) was treated with 1 M HCl (20 mL) in CH2Cl2 (10 mL) and stirred at room temperature for 8 hours. After completion of the reaction, the solution was concentrated, the residue neutralized with NH4OH and extracted with CH2Cl2. The organic layer was separated and concentrated, and the residue was purified by silica gel column chromatography (eluent: MeOH) to afford Intermediate 227-III (636 mg) in 90% yield. Intermediate 222-III (790 mg) was added to a solution of intermediate 227-III (450 mg) in MeOH (20 mL) and stirred at 25 °C for 2 hours. Then NaBH(OAc)3 (2.0 g) was added and the reaction was continued at 25 °C for 12 hours. After completion of the reaction, the solution was concentrated, saturated NaHCO3 solution was added and extracted with CH2Cl2. The organic layer was separated and concentrated, and the residue was purified by silica gel column chromatography (eluent: MeOH) to afford intermediate 227-IV (539 mg) in 60% yield. N1-morpholino-N1-piperazine ethane (240 mg) was added to a 1-pentanol (1 mL) solution of Intermediate 227-IV (160 mg) and stirred at 120 °C for 8 hours. After completion of the reaction, the solution was concentrated and the residue was purified by silica gel column chromatography (eluent: EtOAc/MeOH=5/1) to afford Intermediate 227-V (85 mg) in 40% yield. 20% TFA/CH2Cl2 (1 mL) was added to a solution of CH2Cl2 (1 mL) of intermediate 227-V (85 mg) and stirred at room temperature for 8 hours. After completion of the reaction, the solvent was removed and the residue was purified by silica gel column chromatography (eluent: 21% NH3(aq)/MeOH=1/19) to afford compound 227 (65 mg) in 90% yield. Finally, compound 227 was treated with a solution of CH2Cl2 (1 mL) in 1M HCl (1 mL) for 0.5 hours. After removal of the solvent, the residue was treated with ether and filtered to give the hydrochloride salt of compound 227.CI-MS (M++1): 544.4.

References

[1] Patent: US2006/281712, 2006, A1. Location in patent: Page/Page column 108-109

4-(Boc-Aminomethyl)piperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Di-tert-butyl dicarbonate Palladium Benzyl bromide Tetrahydrofuran Lithium Aluminum Hydride Isonipecotic acid Benzyl chloroformate Methanol

Preparation Products

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View Lastest Price from 4-(Boc-Aminomethyl)piperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(Boc-Aminomethyl)piperidine 135632-53-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Honest Joy Holdings Limited

Product: 4-(Boc-Aminomethyl)piperidine 135632-53-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-01-25

Career Henan Chemical Co

Product: me: 4-(Boc-Aminomethyl)piperidine 135632-53-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

135632-53-0, 4-(Boc-Aminomethyl)piperidineRelated Search:

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4-(2-BOC-AMINOMETHYL) PIPERIDINE

4-AMINOMETHYLPIPERIDINE, BOC PROTECTED

4-(BOC-AMINOMETHYL)PIPERIDINE

4-N-BOC-AMINOMETHYL PIPERIDINE

4-(TERT-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE

4-(TERT-BUTOXYCARBONYLAMINOMETHYL)PIPERIDINE

4-(T-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE

BUTTPARK 43\57-92

(BOC-4-AMINOMETHYL)PIPERIDINE

4-(Aminomethyl)piperidine, 4-BOC protected

PIPERIDIN-4-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER

PIP(4-BOC-AM)

TERT-BUTYL N-(4-PIPERIDINYLMETHYL)CARBAMATE

tert-butyl n-(4-piperidylmethyl)carbamate

TERT-BUTYL (PIPERIDIN-4-YLMETHYL)CARBAMATE

me: 4-(Boc-Aminomethyl)piperidine

4-(Aminomethyl)piperidine, 4-BOC protected 95%

(BOC-4-aminomethyl)piperidine, min. 95 %

Carbamic acid, (4-piperidinylmethyl)-, 1,1-dimethylethyl ester

tert-butyl (piperidin-4-ylmethyl)carbamate(SALTDATA: HCl)

4-(Boc-aminomethyl)-piperidine hydrochloride

tert-butyl piperidin-4-ylmethylcarbamate hydrochloride

1,1-diMethylethyl [(piperidin-4-yl)Methyl]carbaMate

tert-Butyl [(piperidin-4-yl)methyl]carbamate, 4-{[(tert-Butoxycarbonyl)amino]methyl}piperidine

4-(Boc-aminomethyl)piperidine,97%

Carbamic acid, N-(4-piperidinylmethyl)-, 1,1-dimethylethyl ester

tert-Butyl N-(piperidin-4-ylmethyl)carbamate

(4-Piperidylmethyl)carbamic Acid tert-Butyl Ester

tert-Butyl (4-Piperidylmethyl)carbamate

5,7-diethyl-2-(3-nitrophenyl)-1,3-diazaadamantan-11-one

4-(Boc-aminomethyl)piperidine - [A12321]

135632-53-0

Pyrans, Piperidines & Piperazines

pharmacetical

Aminomethyl's

Pyrans, Piperidines &Piperazines

Piperidine