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Gamma-mangostin

Background
Product Name
Gamma-mangostin
CAS No.
31271-07-5
Chemical Name
Gamma-mangostin
Synonyms
Nomangostin;r-Mangostin;Normangostin;γ- Mangostin;γ-Mangostin-RM;Gamma-mangostin;Gamma-mangostin γ-Mangostin;gamma-Mangostin >=98% (HPLC);gamma-Mangostin (r-Mangostin);1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone
CBNumber
CB41040702
Molecular Formula
C23H24O6
Formula Weight
396.43
MOL File
31271-07-5.mol
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Gamma-mangostin Property

Melting point:
206-208 °C
Boiling point:
648.4±55.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
methanol: soluble1mg/mL, colorless to yellow
form 
powder
pka
7.05±0.20(Predicted)
color 
off-white to yellow
InChI
InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3
InChIKey
VEZXFTKZUMARDU-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(O)C(O)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2
LogP
5.744 (est)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
ZD6122330
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL80496
Product name
gamma-Mangostin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$275.2
Updated
2024/03/01
Sigma-Aldrich
Product number
M6824
Product name
gamma-Mangostin
Purity
≥98% (HPLC)
Packaging
10mg
Price
$553
Updated
2024/03/01
Sigma-Aldrich
Product number
M6824
Product name
gamma-Mangostin
Purity
≥98% (HPLC)
Packaging
50mg
Price
$1730
Updated
2024/03/01
Cayman Chemical
Product number
26675
Product name
γ-Mangostin
Packaging
5mg
Price
$123
Updated
2024/03/01
Cayman Chemical
Product number
26675
Product name
γ-Mangostin
Packaging
50mg
Price
$918
Updated
2024/03/01
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Gamma-mangostin Chemical Properties,Usage,Production

Background

Garcinia mangostana L., commonly known as mangosteen, is a tree mainly found in India, Myanmar, Sri Lanka and Thailand. The pericarp of mangosteen has been used in Thailand as an indigenous medicine for treating skin infections, wounds and diarrhea. The major bioactive compounds in mangosteen are xanthone derivatives, with α-mangostin (1, α-M) and Gamma-mangostin (4, γ-M) being the main derivatives isolated. α-M and γ-M possess not only antioxidant activity but also a wide range of biological activities, such as tumour cell-selective apoptosis and the attenuation of amyloid-β neurotoxicity and anti-inflammation. Gamma-mangostin strongly inhibited human colorectal adenocarcinoma cell proliferation. It was shown that γ-mangostin may mediate cytotoxicity via apoptosis in HT29 cells. Hence, it is a strong lead compound candidate in treating colon cancer cell growth and may directly affect colorectal adenocarcinoma cancer susceptibility through its modulation of cell proliferation and apoptosis[1].

Uses

Gamma-Mangostin is a xanthones which displays anti-oxidant properties and could be a promising compound for the therapy of AlzheimerтАЩs disease.

Definition

ChEBI: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense /ital>, it exhibits antitumour activity.

References

[1] Takeshi Yokoyama. “Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor.” Scientific Reports (2015): 13570.

Gamma-mangostin Preparation Products And Raw materials

Raw materials

Preparation Products

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Gamma-mangostin Suppliers

AdooQ BioScience, LLC
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+1 (866) 930-6790
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ALB Technology Limited
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702-983-3769
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888-539-0666
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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BOC Sciences
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View Lastest Price from Gamma-mangostin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Gamma-mangostin 31271-07-5
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-06
Shaanxi Dideu Medichem Co. Ltd
Product
Gamma-mangostin 31271-07-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-14
Shanghai Standard Technology Co., Ltd.
Product
Gamma-mangostin 31271-07-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-03-27

31271-07-5, Gamma-mangostinRelated Search:


  • Gamma-mangostin
  • 1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
  • Normangostin
  • r-Mangostin
  • 1,3,6,7-Tetrahydroxy-2,8-bis(3-Methylbut-2-en-1-yl)-9H-xanthen-9-one
  • 1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone
  • gamma-Mangostin (r-Mangostin)
  • Nomangostin
  • 9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-
  • Gamma-mangostin γ-Mangostin
  • gamma-Mangostin >=98% (HPLC)
  • 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
  • γ- Mangostin
  • γ-Mangostin-RM
  • 31271-07-5