Tozorakimab
- Product Name
- Tozorakimab
- CAS No.
- 2376858-66-9
- Chemical Name
- Tozorakimab
- Synonyms
- Tozorakimab;Tozorakimab (anti-IL-33);Research Grade Tozorakimab;Research Grade Tozorakimab (DHB74004)
- CBNumber
- CB410617030
- Formula Weight
- 0
- MOL File
- Mol file
Tozorakimab Property
- form
- Liquid
- color
- Colorless to light yellow
Tozorakimab Chemical Properties,Usage,Production
Uses
Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease[1].
in vivo
Tozorakimab (0.1-10 mg/kg, i.p., once time) inhibits IL-5 levels in bronchoalveolar lavage fluid of humanized IL-33 genetically modified mice in dose-dependent manner[2].
References
[1] Reid F, et al. Safety, pharmacokinetics and immunogenicity of the anti-interleukin-33 antibody, tozorakimab: results of a phase 1 study in healthy adults and patients with chronic obstructive pulmonary disease. American Thoracic Society. 2022: A2398-A2398.
[2] England E, et al. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction. Sci Rep. 2023 Jun 17;13(1):9825. DOI:10.1038/s41598-023-36642-y
Tozorakimab Preparation Products And Raw materials
Raw materials
Preparation Products
Tozorakimab Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58