Oxybuprocaine

Product Name: Oxybuprocaine
CAS No.: 99-43-4
Chemical Name: Oxybuprocaine
Synonyms: BNX;S-749;Fluress;Novescine;benoxinate;Oxybuprocaine;Butoxyprocaine;Oxybuprocaine USP/EP/BP;2-Diethylaminoethyl 4-amino-3-butoxybenzoate;2-(Diethylamino)ethyl 4-amino-3-N-butoxybenzoate
CBNumber: CB41073494
Molecular Formula: C17H28N2O3
Formula Weight: 308.42
MOL File: 99-43-4.mol

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Oxybuprocaine Property

Boiling point:: bp2 215-218°
Density: 1.052±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Slightly)
pka: 9.16±0.25(Predicted)
form: Oil
color: Clear Pale Yellow
NIST Chemistry Reference: Benoxinate(99-43-4)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS147487
Product name: 2-(Diethylamino)ethyl4-amino-3-butoxybenzoate
Purity: 95%
Packaging: 250mg
Price: $186
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015752
Product name: OXYBUPROCAINE
Purity: 95.00%
Packaging: 0.5G
Price: $186
Updated: 2021/12/16

Ambeed

Product number: A860351
Product name: 2-(Diethylamino)ethyl4-amino-3-butoxybenzoate
Purity: 95%
Packaging: 250mg
Price: $117
Updated: 2021/12/16

Ambeed

Product number: A860351
Product name: 2-(Diethylamino)ethyl4-amino-3-butoxybenzoate
Purity: 95%
Packaging: 1g
Price: $235
Updated: 2021/12/16

Chemenu

Product number: CM161818
Product name: 2-(Diethylamino)ethyl4-amino-3-butoxybenzoate
Purity: 95%
Packaging: 5g
Price: $711
Updated: 2021/12/16

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Oxybuprocaine Chemical Properties,Usage,Production

Originator

Dorsacaine HCl,Dorsey,US,1953

Uses

Anesthetic (topical).

Definition

ChEBI: A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester "caine") used especially in ophthalmology and otolaryngology.

Manufacturing Process

25 grams of 3-oxy-4-nitrobenzoic acid are esterified (ethyl ester) and 26 grams of the ester are dissolved in 200 cc of absolute ether and treated with 7 grams of caustic potash in 20 cc of absolute methanol. The red potassium phenolate with 7 grams of pure butyl bromide and 7 grams of absolute alcohol are heated for 5 hours in the oven to 150°C. When cool, the alcohol is evaporated in vacuo and the butoxy-nitrobenzoic acid ethyl ester is precipitated with water. The substance is sucked off and saponified for 15 minutes with a solution of 2.5 grams of caustic potash in 30 cc of alcohol on a water bath. The alcohol is evaporated in vacuo and the 3-butoxy-4- nitrobenzoic acid is precipitated with hydrochloric acid. It forms needles which melt at 174°C. 7.9 grams of dry acid are boiled for 45 minutes under a reflux condenser with 25 cc of thionyl chloride. The excess of thionyl chloride is then removed in vacuo, and the oil is distilled. The acid chloride has a yellow color and solidifies.
7.3 grams of the acid chloride are treated with 6.6 grams of diethyl-aminoethanol in 20 cc of absolute benzene. The mixture is then warmed for 1 hour on a water bath. When cold, it is treated with a solution of soda and washed with ether. After drying over potash, the ether and benzene are removed by distillation and 3-butoxy-4-nitrobenzoic acid diethylamino-ethyl ester is obtained, having a BP 215°C/2.5 mm.
5.0 grams of this product are hydrogenated in absolute alcohol solution with fresh Raney nickel. When the absorption of hydrogen ceases (5 hours), the solution is filtered and the alcohol evaporated in vacuo. The 3-butoxy-4- aminobenzoic acid diethyl-amino-ethyl ester boils at 215°-218°C at 2 mm pressure; it is an almost colorless oil.
By precipitation of a solution of the ester in absolute ether with hydrogen chloride gas, the dihydrochloride is obtained; upon recrystallization from alcohol/ether, it forms crystals which melt at 196°-197°C.

brand name

Dorsacaine (Novartis).

Therapeutic Function

Local anesthetic

Oxybuprocaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxybuprocaine Suppliers

China 27 Germany 1 India 2 United States 6 Global 36

Zhejiang Haiqiang Chemical Co.,Ltd

Tel: 0571-86050367 0571-86960370 0571-86050387
Fax: 0571-86940780
Email: info@chinahaiqiangchem.com
Country: China
ProdList: 462
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 8752
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10009
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +86-18339805032; +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 13227
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32079
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17365
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

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View Lastest Price from Oxybuprocaine manufacturers

Nantong Guangyuan Chemicl Co,Ltd

Product: Oxybuprocaine 99-43-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-02

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: oxybuprocaine 99-43-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.99
Supply Ability: 20ton
Release date: 2023-12-15

99-43-4, OxybuprocaineRelated Search:

Mepivacaine hydrochloride Dibucaine hydrochloride Betaine Chloroprocaine hydrochloride Cinchocaine Procaine Tris(trimethylsilyl)phosphate ALTRENOGEST Benoxinate Hydrochloride Procaine hydrochloride Procaine penicillin G Benzocaine Mepivacaine Glycine Articaine 4-Aminobenzoic acid axybuprocaine hydrochloride Anthranilic acid

Fluress

4-amino-3-butoxy-2-(diethylamino)ethylester-Benzoicacid

benoxinate

4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl

4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester

4-Amino-3-butoxybenzoic acid 2-diethylaminoethyl ester

S-749

2-(Diethylamino)ethyl 4-amino-3-N-butoxybenzoate

3-Butoxy-4-aminobenzoic acid 2-(diethylamino)ethyl ester

3-Butoxy-4-aminobenzoic acid 2-diethylaminoethyl ester

2-Diethylaminoethyl 4-amino-3-butoxybenzoate

4-Amino-3-butoxybenzoic acid diethylaminoethyl ester

Oxybuprocaine

Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester

Oxybuprocaine USP/EP/BP

OxybuprocaineQ: What is Oxybuprocaine Q: What is the CAS Number of Oxybuprocaine Q: What is the storage condition of Oxybuprocaine Q: What are the applications of Oxybuprocaine

BNX

Butoxyprocaine

Novescine

99-43-4