ChemicalBook > CAS DataBase List > (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid

Product Name
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid
CAS No.
884512-77-0
Chemical Name
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid
Synonyms
Benzenesulfonylchloride,6-ethoxy-;(R)-N-Boc-morpholine-2-carboxylic acid;(R)-4-Boc-morpholine-2-carboxylic acid;(R)/(S)-N-Boc-2-morpholinecarboxylic acid;(R)-N-BOC-2,4-MORPHOLINEDICARBOXYLIC ACID;(2R)-4-BOC-2,4-MORPHOLINEDICARBOXYLIC ACID;(2R)-4-(tert-butoxycarbonyl)morpholin-2-carboxylic acid;(R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid;(2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid;(2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid
CBNumber
CB41094073
Molecular Formula
C10H17NO5
Formula Weight
231.25
MOL File
884512-77-0.mol
More
Less

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid Property

Melting point:
147-150°C
Boiling point:
369.5±42.0 °C(Predicted)
Density 
1.230
storage temp. 
2-8°C
solubility 
DMSO, Methanol
form 
Solid
pka
3.25±0.20(Predicted)
color 
Off-White
InChI
InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1
InChIKey
LGWMTRPJZFEWCX-SSDOTTSWSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCO[C@@H](C(O)=O)C1
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
D472755
Product name
(2R)-4-(1,1-Dimethylethyl)Ester2,4-MorpholinedicarboxylicAcid
Packaging
2.5g
Price
$1190
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148316
Product name
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylicacid
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W9078
Product name
(R)-4-Boc-Morpholine-2-carboxylicacid
Packaging
100mg
Price
$87
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148316
Product name
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylicacid
Packaging
1g
Price
$100
Updated
2021/12/16
Activate Scientific
Product number
AS12063
Product name
(R)-N-Boc-morpholine-2-carboxylic acid
Purity
95+% ee
Packaging
1g
Price
$104
Updated
2021/12/16
More
Less

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid Chemical Properties,Usage,Production

Uses

(2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of renin inhibitors.

Uses

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid is used in the preparation of renin inhibitors.

Synthesis

135065-71-3

884512-77-0

General procedure for the synthesis of (2R)-2,4-morpholine dicarboxylic acid 4-tert-butyl ester from (R)-N-Boc-2-hydroxymethylmorpholine: Saturated aqueous NaHCO3 (15 mL) was added to a solution of tert-butyl (R)-2-(hydroxymethyl)-morpholine-4-carboxylate (1.09 g, 5.0 mmol) in acetone (50 mL) at 0 °C with continuous stirring. Solid NaBr (0.1 g, 1 mmol) and TEMPO (0.015 g, 0.1 mmol) were subsequently added. Trichloroisocyanuric acid (2.32 g, 10.0 mmol) was slowly added dropwise over a period of 20 min at 0 °C. After the dropwise addition, the reaction mixture was slowly warmed to room temperature and stirred overnight. After the reaction was completed, 2-propanol (3 mL) was added and stirring was continued for 30 minutes at room temperature. The reaction solution was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The concentrate was treated with saturated aqueous Na2CO3 (15 mL), and the aqueous phase was washed with EtOAc (5 mL), acidified with 6N HCl, and extracted with EtOAc (5 x 10 mL). The organic layers were combined, dried with Na2SO4 and the solvent was removed under reduced pressure to afford (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (1.07 g, 92% yield) as a white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.20 (br, 1H), 4.12 (d, 1H), 4.02 (d, 1H), 3.84 (m, 1H), 3.62 (m, 1H), 3.04 (m, 2H), 1.44 (s, 9H); Mass Spectrometry (MS) m/z 232 (M+H+).

References

[1] Patent: WO2008/124575, 2008, A1. Location in patent: Page/Page column 112; 114
[2] Patent: US2010/184805, 2010, A1. Location in patent: Page/Page column 30-31
[3] Patent: WO2007/70201, 2007, A1. Location in patent: Page/Page column 176-177
[4] Patent: US2010/317697, 2010, A1. Location in patent: Page/Page column 51
[5] Patent: WO2008/124582, 2008, A1. Location in patent: Page/Page column 96-98

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid Suppliers

Canada 1 CHINA 105 India 2 United Kingdom 2 United States 9 Global 119
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
2986
Advantage
61
Doly Chemical CO.,LTD.
Tel
021-34716221 15800796336
Fax
+86-21-31329566
Email
sales@dolypharm.com
Country
China
ProdList
289
Advantage
55
Shanghai Kuanghao Chemistry Technology Co., Ltd.
Tel
1590082856 15900820856
Fax
021-37285512
Email
83219210@qq.com
Country
China
ProdList
77
Advantage
57
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
Chengdu Dorher Pharmaceutical CO.,Ltd
Tel
028-64259743; 19983537320
Email
bd-focus@focuspharm.com
Country
China
ProdList
682
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
918
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shanghai G&K Biomedical Scientific Inc.
Tel
021-34502253 13391330186
Fax
+86-21-23027826
Email
info@gksci.com
Country
China
ProdList
133
Advantage
52
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
246
Advantage
62
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
China Shenyang Tyschem CO. ,LTD
Tel
+86-024-83607930; 18640359690
Fax
024-83607930
Email
sales@honghuchem.com
Country
China
ProdList
256
Advantage
58
Shanghai Sheepchem Co., Ltd.
Tel
+86 (21) 6715-7650
Fax
+86 (21) 6715-7651
Email
sheepchem@163.com
Country
China
ProdList
994
Advantage
60
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Wuhan HengHeDa Pharm Co., Ltd.
Tel
027-84888681 18086046872
Fax
027-84888682
Email
hhdpharm@hotmail.com
Country
China
ProdList
105
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Hygeia (Chengdu) pharmaceutical technique Co., Ltd
Tel
028-84502008 13568869383
Fax
028-66476329
Email
sales@hygeiapharm.com
Country
China
ProdList
294
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
DebyeTec.com Inc.
Tel
18-086626237 18086626237
Fax
qq:2693528373
Email
2693528373@qq.com
Country
China
ProdList
2973
Advantage
56
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.
Tel
028-028-37664989 15900794981
Email
jingzhichem@163.com
Country
China
ProdList
537
Advantage
55
Zhengzhou Alfachem Co.,Ltd.
Tel
0371-53778726 18003825608
Fax
QQ：2885354392
Email
liuxiaoyan@alfachem.cn
Country
China
ProdList
1986
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Qingdao IniKem BioPharmaTech Co.,Ltd
Tel
0532-58268780 18561687109;
Fax
-
Email
sales@inikem.com
Country
China
ProdList
298
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Wuhan EEChem Technologies Co., Ltd
Tel
0711-3617768 13308685235
Fax
0711-3616558
Email
lihongcai4360@sina.com
Country
China
ProdList
1510
Advantage
55
Greenherbs Science and Technology Development Co., Ltd.
Tel
010-61136123
Fax
+86 (10) 8857-9127
Email
pub02@greenherbs.com.cn
Country
China
ProdList
4049
Advantage
58
Chengdu Focus Pharmaceutical Technology Co., Ltd.
Tel
028-64950838 17340131597
Email
bd-focus@focuspharm.com
Country
China
ProdList
850
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Deyang Chengchuang Pharmaceutical Technology Co., Ltd.
Tel
028-66569636 18227172063
Fax
028-66569636
Email
sales@dyccpharma.com
Country
China
ProdList
49
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9713
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shang Hai Muse Health Tech Co., Ltd.
Tel
021-021-61069951-8018 13262285760
Email
xul@musehealthtech.com
Country
China
ProdList
178
Advantage
58
Shanghai SPAR pharmaceutical technology co., LTD
Tel
021-000000 13917643586;
Email
admin@jingshipharmatech.com
Country
China
ProdList
9859
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Win-Win chemical CO., Limited
Tel
+86-0086-577-64498589 +86-15355981851
Fax
0086-577-56994596
Email
sales@win-winchemical.com
Country
China
ProdList
14359
Advantage
58
More
Less

View Lastest Price from (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid 884512-77-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-13
Career Henan Chemical Co
Product
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid 884512-77-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

884512-77-0, (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acidRelated Search:

tert-Butyl acetoacetate tert-Butyl peroxyacetate Tris(trimethylsilyl)phosphate tert-Butyl methacrylate tert-Butyl bromoacetate Ethyl 2-(Chlorosulfonyl)acetate tert-Butyl chloroacetate tert-Butyl acetate tert-Butyl acrylate DI-TERT-BUTYL ETHER (R)-N-Boc-2-Hydroxymethylmorpholine 2-HYDROXYMETHYL-4-BOC-MORPHOLINE ((R)-morpholin-2-yl)methanol Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI) morpholine 4-BOC-2-MORPHOLINECARBOXYLIC ACID 4-BOC-2-MORPHOLINECARBALDEHYDE (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid

  • (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid
  • (R)-4-Boc-morpholine-2-carboxylic acid
  • (2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid
  • (R)-N-Boc-morpholine-2-carboxylic acid
  • (2R)-2,4-Morpholinedicarboxylic acid 4-(1,1-dimethylethyl) ester
  • (2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid
  • (2R)-4-BOC-2,4-MORPHOLINEDICARBOXYLIC ACID
  • (R)-N-BOC-2,4-MORPHOLINEDICARBOXYLIC ACID
  • (R)/(S)-N-Boc-2-morpholinecarboxylic acid
  • (2R)-4-(tert-butoxycarbonyl)morpholin-2-carboxylic acid
  • (2R)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid
  • (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid884512-77-0
  • 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester, (2R)-
  • Benzenesulfonylchloride,6-ethoxy-
  • 884512-77-0
  • 88452-77-0