N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Product Name: N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
CAS No.: 289042-10-0
Chemical Name: N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
Synonyms: -4-(4-fluorophenyl);N-(5-((Diphenylphosphoryl);-6-isopropylpyrimidin-2-yl);Rosuvastatin Intermediates ZD9;Rosuvastatin InterMediate Z-8.1;rosuvastatin intermediates Z-8.1;Rosuvastatin Diphenylphosphine Oxide;N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl];N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethan;N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesu
CBNumber: CB41115873
Molecular Formula: C28H29FN3O3PS
Formula Weight: 537.59
MOL File: 289042-10-0.mol

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N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide Property

Melting point:: 185-187°C
Boiling point:: 679.1±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
pka: -0.57±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C28H29FN3O3PS/c1-20(2)26-25(19-36(33,23-11-7-5-8-12-23)24-13-9-6-10-14-24)27(21-15-17-22(29)18-16-21)31-28(30-26)32(3)37(4,34)35/h5-18,20H,19H2,1-4H3
InChIKey: CVRDGWDBQZPJJI-UHFFFAOYSA-N
SMILES: CS(N(C1=NC(C(C)C)=C(CP(C2=CC=CC=C2)(C2=CC=CC=C2)=O)C(C2=CC=C(F)C=C2)=N1)C)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D491600
Product name: Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphineOxide
Packaging: 1g
Price: $1110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22487
Product name: Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphine oxide
Packaging: 1g
Price: $1528.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001003
Product name: N-[5-(DIPHENYLPHOSPHINOYLMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYLPYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE
Purity: 95.00%
Packaging: 1G
Price: $1871.1
Updated: 2021/12/16

Matrix Scientific

Product number: 093791
Product name: N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
Purity: 95+%
Packaging: 250mg
Price: $364
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22487
Product name: Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphine oxide
Packaging: 250mg
Price: $462.5
Updated: 2021/12/16

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N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide Chemical Properties,Usage,Production

Uses

An intermediate in the production of Rosuvastatin (R700500) derivatives.

Synthesis

799842-07-2

719-80-2

289042-10-0

Under argon protection, ethyldiphenylphosphite (12.6 g, 55 mmol) was added to a solution of 5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine (15.2 g, 36.6 mmol) in toluene (370 mL), and the reaction mixture was stirred for 3 hours at 60 °C. Upon completion of the reaction, the mixture was concentrated. The residue was dissolved in toluene (10 mL), hexane (10 mL) was added and the product N-[5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide precipitated as a colorless powder, which was collected by filtration to give 14.3 g (73% yield). The product was structurally confirmed by nuclear magnetic resonance hydrogen (1H NMR, 300 MHz, CDCl3), carbon (13C NMR, 75 MHz, CDCl3) and phosphorus (31P NMR, 121 MHz, CDCl3) spectra.

References

[1] Patent: WO2004/103977, 2004, A2. Location in patent: Page 24-25
[2] Patent: WO2012/2741, 2012, A2. Location in patent: Page/Page column 20
[3] Organic Letters, 2018, vol. 20, # 11, p. 3286 - 3290

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide Suppliers

Canada 1 China 125 India 1 United Kingdom 1 United States 5 Global 133

Jiangsu Greature Bio-Medicine Co., Ltd.

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View Lastest Price from N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide manufacturers

Hangzhou ICH Biofarm Co., Ltd

Product: Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl 289042-10-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200
Release date: 2023-07-11

Career Henan Chemical Co

Product: N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 289042-10-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-16

289042-10-0, N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamideRelated Search:

tert-Butylchlorodiphenylsilane p-Toluenesulfonamide Diphenylphosphine Benzenesulfonamide Diphenylsilane Sulfanilamide Chlorodiphenylphosphine Phosphonium, [[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]me Diphenyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl -methyl]phosphine Oxide-D6 (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate (4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidinyl-5-yl-formyl N-Methyl methanesulfonamide

4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino] pyriminl-5-yl- phosphine oxide

Diphenyl [4-(4-fluorophenyl)- 6-isopropyl-2-[(n-Methyl- n-ethylsulfonyl)aMino] pyriMidine-5-yl- ethyl]phosphine

Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-Methyl-n-Methylsulfonyl)aMino]pyriMidine-5-yl-Methyl]phosphine oxide

Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonyl)aMino-pyriMidin-5-yl-Methyl]phosphine Oxide

N-[5-[(Diphenylphosphinyl)Methyl]-4-(4-fluorophenyl)-6-(1-Methylethyl)-2-pyriMidinyl]-N-MethylMethanesulfonaMide

Rosuvastatin Diphenylphosphine Oxide

N-[5-(Diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

Rosuvastatin Intermediates ZD9

Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl

Triphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methyl]phosphine bromine

Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosph

4-(4-Fluorophenyl)-5-(diphenylphosphinyl)methyl-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine

Rosuvastatin InterMediate Z-8.1

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesu

N-(5-((Diphenylphosphoryl)Methyl)-4-(4-fluorophenyl)-6-isopropylpyriMidin-2-yl)-N-MethylMethanesulfonaMide

rosuvastatin intermediates Z-8.1

Z-8: DIPHENYL [4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(N-METHYL-N-METHYLSULFONYL) AMINO] PYRIMIDINE-5-YL-METHYL] PHOSPHINE OXIDE

-4-(4-fluorophenyl)

-6-isopropylpyrimidin-2-yl)

N-(5-((Diphenylphosphoryl)

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethan

N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide(Z8.3)

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfon

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]

N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (Rosuvastatin Impurity)

N-[5-[(Diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethan

289042-10-0

C28H29FN3O3PS

Rosuvastatin intermediates