4Hydroxy Tamoxifen Property

Melting point:

150-153°C

Boiling point:

514.4±50.0 °C(Predicted)

Density 

1.092±0.06 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Dichloromethane, Methanol (Slightly)

form 

Solid

pka

10.32±0.15(Predicted)

color 

White to Off-White

Stability:

Light Sensitive

Hazard and Precautionary Statements (GHS)

4Hydroxy Tamoxifen Chemical Properties,Usage,Production

Description

4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.

Chemical Properties

White Solid

Uses

A metabolite of Tamoxifen (T006000).