TRI-P-TOLYLPHOSPHINE
- Product Name
- TRI-P-TOLYLPHOSPHINE
- CAS No.
- 1038-95-5
- Chemical Name
- TRI-P-TOLYLPHOSPHINE
- Synonyms
- TRIS(P-TOLYL)PHOSPHINE;TRIS(4-TOLYL)PHOSPHINE;tris(4-Methylphenyl)phosphane;Tri(p-toL;AURORA KA-1142;Tri-p-tolyphosphine;TRI-4-TOLYLPHOSPHINE;TRI-P-TOLYLPHOSPHINE;TRI-P-TOYL PHOSPHINE;tris-p-tolylphosphane
- CBNumber
- CB4117584
- Molecular Formula
- C21H21P
- Formula Weight
- 304.37
- MOL File
- 1038-95-5.mol
TRI-P-TOLYLPHOSPHINE Property
- Melting point:
- 144-148 °C(lit.)
- Boiling point:
- 399.8±41.0 °C(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Crystals or Crystalline Powder
- color
- White to light yellow
- Water Solubility
- Insoluble in water.
- Sensitive
- Air Sensitive
- BRN
- 651045
- InChI
- InChI=1S/C21H21P/c1-16-4-10-19(11-5-16)22(20-12-6-17(2)7-13-20)21-14-8-18(3)9-15-21/h4-15H,1-3H3
- InChIKey
- WXAZIUYTQHYBFW-UHFFFAOYSA-N
- SMILES
- P(C1=CC=C(C)C=C1)(C1=CC=C(C)C=C1)C1=CC=C(C)C=C1
- CAS DataBase Reference
- 1038-95-5(CAS DataBase Reference)
- EPA Substance Registry System
- Phosphine, tris(4-methylphenyl)- (1038-95-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- SZ3880000
- F
- 10-23
- TSCA
- Yes
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 287830
- Product name
- Tri(p-tolyl)phosphine
- Purity
- 98%
- Packaging
- 5g
- Price
- $59.62
- Updated
- 2025/07/31
- Product number
- T0862
- Product name
- Tri(p-tolyl)phosphine
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- T0862
- Product name
- Tri(p-tolyl)phosphine
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- 15-8120
- Product name
- Tri-p-tolylphosphine, 98%
- Packaging
- 5g
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 15-8120
- Product name
- Tri-p-tolylphosphine, 98%
- Packaging
- 25g
- Price
- $235
- Updated
- 2024/03/01
TRI-P-TOLYLPHOSPHINE Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
suzuki reaction
Uses
Tri(p-tolyl)phosphine is used as pharmaceutical intermediate.
Application
Tri-p-tolylphosphine is commonly used in pharmaceutical manufacturing as a ligand in catalysis, particularly in palladium-catalyzed cross-coupling reactions. These reactions are crucial for forming carbon-carbon bonds in drug synthesis.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Cross Couplings
Synthesis
20 g Sodium (0.870 mol) was added to 125 ml toluene, then the mixture was heated up to 383 K and stirred to form fine particles of sodium, which subsequently melted. Then the temperature was lowered to 323 K. P-chlorotoluene (55.2 g /0.436 mol) and phosphorus trichloride (19.8 g / 0.144 mol) were added, keeping the temperature between 323 K and 333 K for two hours. The product was concentrated in a vacuum to gain a white solid (35.0 g, 80%) (Brown et al., 1988). The pure title compound (TRI-P-TOLYLPHOSPHINE) was obtained by crystallizing from methanol.[1]
References
[1] Tri-p-tolylphosphine. Crystallographic Communications. August 2008 64(Pt 9):o1783-o1783
TRI-P-TOLYLPHOSPHINE Preparation Products And Raw materials
Raw materials
Preparation Products
TRI-P-TOLYLPHOSPHINE Suppliers
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View Lastest Price from TRI-P-TOLYLPHOSPHINE manufacturers
- Product
- Tri-p-tolylphosphine 1038-95-5
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- Tri-p-tolylphosphine 1038-95-5
- Price
- US $7.00-62.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 100kg
- Release date
- 2023-12-07
- Product
- Tri-p-tolylphosphine 1038-95-5
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-01-14