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TRI-P-TOLYLPHOSPHINE

Product Name
TRI-P-TOLYLPHOSPHINE
CAS No.
1038-95-5
Chemical Name
TRI-P-TOLYLPHOSPHINE
Synonyms
TRIS(P-TOLYL)PHOSPHINE;TRIS(4-TOLYL)PHOSPHINE;tris(4-Methylphenyl)phosphane;Tri(p-toL;AURORA KA-1142;Tri-p-tolyphosphine;TRI-4-TOLYLPHOSPHINE;TRI-P-TOLYLPHOSPHINE;TRI-P-TOYL PHOSPHINE;tris-p-tolylphosphane
CBNumber
CB4117584
Molecular Formula
C21H21P
Formula Weight
304.37
MOL File
1038-95-5.mol
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TRI-P-TOLYLPHOSPHINE Property

Melting point:
144-148 °C(lit.)
Boiling point:
399.8±41.0 °C(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Crystals or Crystalline Powder
color 
White to light yellow
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
BRN 
651045
InChI
InChI=1S/C21H21P/c1-16-4-10-19(11-5-16)22(20-12-6-17(2)7-13-20)21-14-8-18(3)9-15-21/h4-15H,1-3H3
InChIKey
WXAZIUYTQHYBFW-UHFFFAOYSA-N
SMILES
P(C1=CC=C(C)C=C1)(C1=CC=C(C)C=C1)C1=CC=C(C)C=C1
CAS DataBase Reference
1038-95-5(CAS DataBase Reference)
EPA Substance Registry System
Phosphine, tris(4-methylphenyl)- (1038-95-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
SZ3880000
F 
10-23
TSCA 
Yes
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
287830
Product name
Tri(p-tolyl)phosphine
Purity
98%
Packaging
5g
Price
$59.62
Updated
2025/07/31
TCI Chemical
Product number
T0862
Product name
Tri(p-tolyl)phosphine
Purity
>96.0%(GC)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
T0862
Product name
Tri(p-tolyl)phosphine
Purity
>96.0%(GC)
Packaging
25g
Price
$98
Updated
2025/07/31
Strem Chemicals
Product number
15-8120
Product name
Tri-p-tolylphosphine, 98%
Packaging
5g
Price
$60
Updated
2024/03/01
Strem Chemicals
Product number
15-8120
Product name
Tri-p-tolylphosphine, 98%
Packaging
25g
Price
$235
Updated
2024/03/01
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TRI-P-TOLYLPHOSPHINE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

Tri(p-tolyl)phosphine is used as pharmaceutical intermediate.

Application

Tri-p-tolylphosphine is commonly used in pharmaceutical manufacturing as a ligand in catalysis, particularly in palladium-catalyzed cross-coupling reactions. These reactions are crucial for forming carbon-carbon bonds in drug synthesis.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Cross Couplings

Synthesis

20 g Sodium (0.870 mol) was added to 125 ml toluene, then the mixture was heated up to 383 K and stirred to form fine particles of sodium, which subsequently melted. Then the temperature was lowered to 323 K. P-chlorotoluene (55.2 g /0.436 mol) and phosphorus trichloride (19.8 g / 0.144 mol) were added, keeping the temperature between 323 K and 333 K for two hours. The product was concentrated in a vacuum to gain a white solid (35.0 g, 80%) (Brown et al., 1988). The pure title compound (TRI-P-TOLYLPHOSPHINE) was obtained by crystallizing from methanol.[1]

References

[1] Tri-p-tolyl­phosphine. Crystallographic Communications. August 2008 64(Pt 9):o1783-o1783

TRI-P-TOLYLPHOSPHINE Preparation Products And Raw materials

Raw materials

Ethanol 5-Bromo-m-xylene Phosphorus trichloride 4-Bromotoluene Tetrahydrofuran Ethyl acetate Hydrochloric acid Dichloromethane PETROLEUM ETHER Magnesium

Preparation Products

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TRI-P-TOLYLPHOSPHINE Suppliers

Austria 1 Belgium 3 China 290 Germany 6 India 22 Japan 6 Norway 1 Russia 1 Slovakia 1 Switzerland 3 United Kingdom 11 United States 42 Global 387
Acros Organics (Part of Thermo Fisher Scientific )
Tel
--
Fax
--
Email
fo@acros.com
Country
Belgium
ProdList
3824
Advantage
58
Alkemi BVBA
Tel
--
Fax
--
Email
nfo@alkemi.be
Country
Belgium
ProdList
2201
Advantage
58
Acros Organics
Tel
--
Fax
--
Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
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View Lastest Price from TRI-P-TOLYLPHOSPHINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Tri-p-tolylphosphine 1038-95-5
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Shanghai UCHEM Inc.
Product
Tri-p-tolylphosphine 1038-95-5
Price
US $7.00-62.00/g
Min. Order
5g
Purity
0.98
Supply Ability
100kg
Release date
2023-12-07
Shaanxi Dideu Medichem Co. Ltd
Product
Tri-p-tolylphosphine 1038-95-5
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2020-01-14

1038-95-5, TRI-P-TOLYLPHOSPHINERelated Search:

Tributyl(2-phenylethenyl)stannane DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) METHYLTRIBUTYLPHOSPHONIUM IODIDE Tributylphosphine TRI-N-BUTYLPHOSPHINE OXIDE TRIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PHOSPHINE Triphenylphosphine TRIS(PENTAFLUOROPHENYL)BORANE TRIS(PENTAFLUOROPHENYL)PHOSPHINE Tris(nonylphenyl) phosphite TRIS(2-METHOXYPHENYL)PHOSPHINE PHOSPHOROUS ACID TRIS(4-METHYLPHENYL) ESTER TRIMESITYLPHOSPHINE TRI-P-TOLYLPHOSPHINE TRIS[4-(PERFLUOROOCTYL)PHENYL]PHOSPHINE TRIS(4-TRIFLUOROMETHYLPHENYL)PHOSPHINE Dibromobis(tri-o-tolylphosphine)palladium(II), Pd 12% Tri(o-tolyl)phosphine

  • Three pairs of benzyl phosphonic
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  • Tri(p-tolyl)phosphine 98%
  • LABOTEST-BB LTBB005429
  • AURORA KA-1142
  • TRI-4-TOLYLPHOSPHINE
  • TRIS(P-TOLYL)PHOSPHINE
  • TRI-P-TOLYLPHOSPHINE
  • TRIS(4-METHYLPHENYL)PHOSPHINE
  • TRIS(4-TOLYL)PHOSPHINE
  • PHOSPHORUS TRI-P-TOLYL
  • Phosphine, tri-p-tolyl-
  • Phosphine, tris(p-tolyl)-
  • tri-(4-Methylphenyl)phosphine
  • Tri-para-tolylphosphine
  • tris(4-methylphenyl)-phosphin
  • Tris(p-methylphenyl)phosphine
  • tris(p-tolyl)-phosphin
  • Tri(p-toL
  • Tri-p-tolyphosphine
  • Tris(p-tolyl)phosphine, 98+%
  • Tri-p-tolylphosphine,98%
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  • TRIS(P-TOLYL)PHOSPHINE (TPTP)
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  • tris(4-Methylphenyl)phosphane
  • Phosphine,tris(4-Methylphenyl)-
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  • Tri-p-tolylphosphine, 98%, for synthesis
  • tris-p-tolylphosphane
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  • pCH3C6H43P
  • Catalysis and Inorganic Chemistry
  • Phosphine Ligands
  • Phosphorus Compounds
  • Basic Phosphine LigandsCatalysis and Inorganic Chemistry
  • Catalysis and Inorganic Chemistry
  • Cross-Coupling
  • Phosphine Ligands
  • Phosphorus Compounds
  • Phosphine Ligands
  • Synthetic Organic Chemistry
  • organophosphorus ligand
  • Achiral Phosphine
  • Aryl Phosphine