ACPA
- Product Name
- ACPA
- CAS No.
- 229021-64-1
- Chemical Name
- ACPA
- Synonyms
- ACPA;PRTN3;ARACHIDONYLCYCLOPROPYLAMIDE;ACPA (in Tocrisolve(TM) 100);ARACHIDONOYL CYCLOPROPYLAMIDE;Arachidonylcyclopropylamide (ACPA);Recombinant Human PRTN3 Protein, His Tag;N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;Monoclonal Anti-PRTN3 antibody produced in mouse;α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid
- CBNumber
- CB4124177
- Molecular Formula
- C23H37NO
- Formula Weight
- 343.55
- MOL File
- 229021-64-1.mol
ACPA Property
- Boiling point:
- 502.4±50.0 °C(Predicted)
- Density
- 0.93±0.1 g/cm3(Predicted)
- RTECS
- JX3841600
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- Pale yellow oil.
- pka
- 16.13±0.20(Predicted)
- Sensitive
- Air Sensitive
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- J67376
- Product name
- N-Arachidonylcyclopropylamide, 98%
- Packaging
- 10mg
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 91053
- Product name
- Arachidonoyl Cyclopropylamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 91053
- Product name
- Arachidonoyl Cyclopropylamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 91053
- Product name
- Arachidonoyl Cyclopropylamide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 91053
- Product name
- Arachidonoyl Cyclopropylamide
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $477
- Updated
- 2024/03/01
ACPA Chemical Properties,Usage,Production
Description
Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Uses
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).
Biological Activity
Potent and selective CB 1 agonist (K i = 2.2 nM). Displays 325-fold selectivity over CB 2 receptors. Active in vivo . Also available in water soluble emulsion (N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
Enzyme inhibitor
This highly selective, synthetic CB1 receptor agonist (FW = 343.55 g/mol; CAS 229021-64-1), also known as arachidonylcyclopropylamide and N(cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, targets CB1 cannabinoid receptor agonist (Ki = 2.2 nM) with >325-fold selectivity over CB2 receptors. Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. ACPA possesses the characteristics of CB1 receptor agonists, inhibiting forskolininduced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [35S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. See also ACEA
ACPA Preparation Products And Raw materials
Raw materials
Preparation Products
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