ACPA

Product Name: ACPA
CAS No.: 229021-64-1
Chemical Name: ACPA
Synonyms: ACPA;PRTN3;ARACHIDONYLCYCLOPROPYLAMIDE;ACPA (in Tocrisolve(TM) 100);ARACHIDONOYL CYCLOPROPYLAMIDE;Arachidonylcyclopropylamide (ACPA);Recombinant Human PRTN3 Protein, His Tag;N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;Monoclonal Anti-PRTN3 antibody produced in mouse;α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid
CBNumber: CB4124177
Molecular Formula: C23H37NO
Formula Weight: 343.55
MOL File: 229021-64-1.mol

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ACPA Property

Boiling point:: 502.4±50.0 °C(Predicted)
Density: 0.93±0.1 g/cm3(Predicted)
RTECS: JX3841600
storage temp.: −20°C
solubility: DMSO: soluble
form: Pale yellow oil.
pka: 16.13±0.20(Predicted)
Sensitive: Air Sensitive

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67376
Product name: N-Arachidonylcyclopropylamide, 98%
Packaging: 10mg
Price: $111
Updated: 2021/12/16

Cayman Chemical

Product number: 91053
Product name: Arachidonoyl Cyclopropylamide
Purity: ≥98%
Packaging: 5mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 91053
Product name: Arachidonoyl Cyclopropylamide
Purity: ≥98%
Packaging: 10mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 91053
Product name: Arachidonoyl Cyclopropylamide
Purity: ≥98%
Packaging: 50mg
Price: $274
Updated: 2024/03/01

Cayman Chemical

Product number: 91053
Product name: Arachidonoyl Cyclopropylamide
Purity: ≥98%
Packaging: 100mg
Price: $477
Updated: 2024/03/01

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ACPA Chemical Properties,Usage,Production

Description

Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with K_i values of 2.2 and 715 nM for CB₁ and CB₂ receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB₁ receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.

Uses

A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).

Biological Activity

Potent and selective CB 1 agonist (K i = 2.2 nM). Displays 325-fold selectivity over CB 2 receptors. Active in vivo . Also available in water soluble emulsion (N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).

Enzyme inhibitor

This highly selective, synthetic CB1 receptor agonist (FW = 343.55 g/mol; CAS 229021-64-1), also known as arachidonylcyclopropylamide and N(cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, targets CB1 cannabinoid receptor agonist (Ki = 2.2 nM) with >325-fold selectivity over CB2 receptors. Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. ACPA possesses the characteristics of CB1 receptor agonists, inhibiting forskolininduced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [35S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. See also ACEA

ACPA Preparation Products And Raw materials

Raw materials

Preparation Products

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ACPA Suppliers

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229021-64-1, ACPARelated Search:

AM 251 ACEA AM 630 2-AG BML-190 5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE ARACHIDONAMIDE NOLADIN ETHER MEAD ACID ETHANOLAMIDE Arachidonyl-2′-chloroethylamide hydrate BOC-ACPA-OH FMOC-ACPA-OH ACPA BOC-ACPA-OH (1-(BOC-AMINOMETHYL)CYCLOPROPYL-1-CARBOXYLIC ACID) AcpA protein

ACPA

ARACHIDONYLCYCLOPROPYLAMIDE

ARACHIDONOYL CYCLOPROPYLAMIDE

N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE

α-Amino-3-carboxy-5-methyl-4-isoxazolepropionic acid

α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid

ACPA (in Tocrisolve(TM) 100)

(5Z,8Z,11Z,14Z)-N-Cyclopropyl-5,8,11,14-eicosatetraenaMide

Monoclonal Anti-PRTN3 antibody produced in mouse

PRTN3

Arachidonylcyclopropylamide (ACPA)

Recombinant Human PRTN3 Protein, His Tag

5,8,11,14-Eicosatetraenamide, N-cyclopropyl-, (5Z,8Z,11Z,14Z)-

229021-64-1

C23H37NO

Cannabinoid receptor

Cannabinoid

Agonist

Fatty Acid Derivatives & Lipids

Glycerols

Intermediates & Fine Chemicals

Pharmaceuticals