Description Applications Safety Information
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Isothiazolinones

Description Applications Safety Information
Product Name
Isothiazolinones
CAS No.
26172-55-4
Chemical Name
Isothiazolinones
Synonyms
CMIT;Isothiazolinone;CMI;CMIT/MIT;5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE;MCI;5-Chloro-2-methyl-3(2H)-isothiazolone;Chloromethylisothiazolinone;5-chloro-2-methyl-2H-isothiazol-3-one;isothiazolin
CBNumber
CB4132565
Molecular Formula
C4H4ClNOS
Formula Weight
149.6
MOL File
26172-55-4.mol
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Isothiazolinones Property

Melting point:
42-45?C
Boiling point:
109.7°C
Density 
1.25 (14% aq.)
refractive index 
n20/D 1.378
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka
-4.06±0.40(Predicted)
form 
Liquid
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
0.240 (est)
CAS DataBase Reference
26172-55-4(CAS DataBase Reference)
NIST Chemistry Reference
5-Chloro-2-methyl-3(2h)-isothiazolone(26172-55-4)
EPA Substance Registry System
5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)
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Safety

Hazard Codes 
C,N,T,Xn
Risk Statements 
34-43-50-20/21/22-50/53-23/24/25-42/43
Safety Statements 
26-36/37/39-45-60-61-24-28-36/37-23
RIDADR 
UN 1760 8/PG 2
WGK Germany 
1
RTECS 
NX8156850
HazardClass 
8
PackingGroup 
III
HS Code 
3808929090
Hazardous Substances Data
26172-55-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1597
Product name
CMIT/MIT
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1ml
Price
$97.5
Updated
2024/03/01
TRC
Product number
C369235
Product name
5-Chloro-2-methyl-3-isothiazolone
Packaging
2.5mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
C5029-26
Product name
5-Chloro-2-
Packaging
2.5mg
Price
$496
Updated
2021/12/16
Usbiological
Product number
435989
Product name
5-Chloro-2-
Packaging
1mg
Price
$360
Updated
2021/12/16
Usbiological
Product number
161851
Product name
5-Chloro-2-
Packaging
1g
Price
$418
Updated
2021/12/16
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Isothiazolinones Chemical Properties,Usage,Production

Description

Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.

Applications

Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.

Safety Information

The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone.

Description

Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.

Chemical Properties

Liquid

Uses

Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.

Uses

Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.

Uses

Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.

Uses

A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.

Definition

ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.

Isothiazolinones Preparation Products And Raw materials

Raw materials

Preparation Products

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Isothiazolinones Suppliers

INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Dr. Ehrenstorfer GmbH
Tel
--
Fax
--
Email
info@analytical-standards.com
Country
Germany
ProdList
5545
Advantage
66
Ferner GmbH
Tel
--
Fax
--
Email
ChemosD@donau.de
Country
Germany
ProdList
2
Advantage
34
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View Lastest Price from Isothiazolinones manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Isothiazolinones 26172-55-4
Price
US $100.00-75.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-23
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Isothiazolinone 26172-55-4
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Isothiazolinones 26172-55-4
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-06-03

26172-55-4, IsothiazolinonesRelated Search:


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