pseurotin
- Product Name
- pseurotin
- CAS No.
- 58523-30-1
- Chemical Name
- pseurotin
- Synonyms
- PB-1;pseurotin;NSC 348694;Pseurotin A, chitin synthase inhibitor;(5S,8S,9R)-8-benzoyl-2-[(Z,1S,2S)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;(5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione;1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)-
- CBNumber
- CB41326785
- Molecular Formula
- C22H25NO8
- Formula Weight
- 431.44
- MOL File
- 58523-30-1.mol
pseurotin Property
- Melting point:
- 126.0-126.9℃
- Boiling point:
- 751.5±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (10 mg/ml)
- pka
- 14.76±0.20(Predicted)
- form
- White to off-white powder.
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 14441
- Product name
- Pseurotin A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 14441
- Product name
- Pseurotin A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $326
- Updated
- 2024/03/01
- Product number
- 298441
- Product name
- PB1
- Packaging
- 100ug
- Price
- $559
- Updated
- 2021/12/16
- Product number
- 298440
- Product name
- PB1
- Packaging
- 100ug
- Price
- $559
- Updated
- 2021/12/16
- Product number
- P839635
- Product name
- PseurotinA
- Packaging
- 5mg
- Price
- $900
- Updated
- 2021/12/16
pseurotin Chemical Properties,Usage,Production
Description
Pseurotin A (58523-30-1) is a fungal metabolite with novel structure. Displays potent neuritogenic activity in PC12 cells. Induces multipolar and branching neurites comparable to that produced by β-NGF.1 Displays immunosuppressive activity via inhibition of immunoglobulin E production in vitro.2 Displays antiproliferative effects on four glioma cell lines by regulating tumor metabolic enzymes.3 Inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppression of ROS.4
Uses
Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.
Uses
Pseurotin A shows antiparasitic and anticancer activity. It exhibits inhibition towards IgE (immunoglobin E) production.
Definition
ChEBI: A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.
in vivo
Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity[3].
| Animal Model: | HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)[1] |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; 7X/week, 30 days |
| Result: | Significantly suppressed the growth of BT474 tumors. |
IC 50
Microbial Metabolite
storage
+4°C
References
[1] D KOMAGATA. Novel neuritogenic activities of pseurotin A and penicillic acid.[J]. Journal of Antibiotics, 1996, 49 9: 958-959. DOI:10.7164/antibiotics.49.958
[2] MINORU ISHIKAWA. Pseurotin A and its analogues as inhibitors of immunoglobuline E production[J]. Bioorganic & Medicinal Chemistry Letters, 2009, 19 5: Pages 1457-1460. DOI:10.1016/j.bmcl.2009.01.029
[3] KOMAL ANJUM . Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes[J]. Natural Product Research, 2018, 32 11: Pages 1353-1356. DOI:10.1080/14786419.2017.1343329
[4] KAI CHEN. Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species.[J]. Theranostics, 2019, 9 6: 1634-1650. DOI:10.7150/thno.30206
pseurotin Preparation Products And Raw materials
Raw materials
Preparation Products
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