ChemicalBook > CAS DataBase List > (4-Pyrazol-1-ylphenyl)methanol

(4-Pyrazol-1-ylphenyl)methanol

Product Name
(4-Pyrazol-1-ylphenyl)methanol
CAS No.
143426-49-7
Chemical Name
(4-Pyrazol-1-ylphenyl)methanol
Synonyms
CPD2800-A2;BUTTPARK 98\50-44;RARECHEM AL BD 1319;4-Pyrazol-1-ylbenzyl alcohol;4-(1-PYRAZOLYL)BENZYLALCOHOL;(4-PYRAZOL-1-YL-PHENYL)METHANOL;[4-(1-Pyrazolyl)phenyl]Methanol;4-(1H-Pyrazol-1-yl)benzyl alcohol;1-[4-Hydroxymethyl)phenyl]pyrazole;(4-PYRAZOL-1-YL-PHENYL)METHANOL 95%
CBNumber
CB4133087
Molecular Formula
C10H10N2O
Formula Weight
174.2
MOL File
143426-49-7.mol
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(4-Pyrazol-1-ylphenyl)methanol Property

Melting point:
76-80°C
Boiling point:
324.3±25.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
14.25±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
143426-49-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
HazardClass 
IRRITANT
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
P846903
Product name
[4-(1H-Pyrazol-1-yl)phenyl]methanol
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
P846903
Product name
[4-(1H-Pyrazol-1-yl)phenyl]methanol
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR23294
Product name
[4-(1H-Pyrazol-1-yl)phenyl]methanol
Packaging
1g
Price
$16
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-U8
Product name
4-(1H-Pyrazol-1-yl)benzyl alcohol
Packaging
1g
Price
$39
Updated
2021/12/16
Apolloscientific
Product number
OR23294
Product name
[4-(1H-Pyrazol-1-yl)phenyl]methanol
Packaging
5g
Price
$58
Updated
2021/12/16
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(4-Pyrazol-1-ylphenyl)methanol Chemical Properties,Usage,Production

Synthesis

143426-47-5

143426-49-7

General procedure for the synthesis of 4-pyrazol-1-ylbenzyl alcohol from methyl 4-(1H-pyrazol-1-yl)benzoate: G) Synthesis of [4-(1H-pyrazol-1-yl)phenyl]methanol To a solution of ethyl 4-(1H-pyrazol-1-yl)benzoate (73.7 g) in tetrahydrofuran (THF, 500 mL), sodium borohydride (19.5 g) and calcium chloride (56.8 g) were slowly added under cooling in an ice bath. The reaction mixture was stirred at room temperature for 16 h, followed by heating and refluxing for 2 days. After completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate (4 times). The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was washed with tert-butyl methyl ether to give 4-pyrazol-1-ylbenzyl alcohol (49.6 g) as a white solid. Product characterization: 1H NMR (400 MHz, CDCl3) δ 2.79 (1H, br s), 4.68 (2H, s), 6.45 (1H, t, J = 2.0 Hz), 7.38 (2H, d, J = 7.6 Hz), 7.61 (2H, d, J = 8.4 Hz), 7.70 (1H, s), 7.89 (1H, d, J = 1.6 Hz).

References

[1] European Journal of Medicinal Chemistry, 1992, vol. 27, # 3, p. 219 - 228
[2] Patent: WO2015/163485, 2015, A1. Location in patent: Paragraph 0387

(4-Pyrazol-1-ylphenyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4-Pyrazol-1-ylphenyl)methanol manufacturers

Career Henan Chemical Co
Product
(4-Pyrazol-1-ylphenyl)methanol 143426-49-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

143426-49-7, (4-Pyrazol-1-ylphenyl)methanolRelated Search:

Methanol 4-Methoxybenzyl alcohol Phenyl salicylate Triphenylmethanol 2-Methyl-1-phenyl-2-propanol Benzyl alcohol Diphenyl ether PHENYL VALERATE PHENYL RESIN Phenylacetic acid 4-(1H-PYRAZOL-1-YL)BENZOIC ACID p-(2H-Indazol-2-yl)-benzoic acid METHYL 4-(1H-PYRAZOL-1-YL)BENZENECARBOXYLATE 4-[4-(4-CHLOROPHENYL)-1H-PYRAZOL-1-YL]BENZOIC ACID 4-(4-PYRIMIDIN-4-YL-1H-PYRAZOL-1-YL)BENZOICACID 4-(5-AMINO-3-METHYL-PYRAZOL-1-YL)-BENZOIC ACID 4-(5-AMINO-3-METHYL-PYRAZOL-1-YL)-BENZOIC ACID HYDROCHLORIDE (4-Pyrazol-1-ylphenyl)methanol

  • BUTTPARK 98\50-44
  • RARECHEM AL BD 1319
  • (4-PYRAZOL-1-YL-PHENYL)METHANOL
  • 4-(1-PYRAZOLYL)BENZYLALCOHOL
  • [4-(1H-PYRAZOL-1-YL)PHENYL]METHANOL
  • 4-Pyrazol-1-ylbenzyl alcohol
  • (4-PYRAZOL-1-YL-PHENYL)METHANOL 95%
  • [4-(1-Pyrazolyl)phenyl]Methanol
  • 4-(1H-Pyrazol-1-yl)benzyl alcohol, 1-[4-(Hydroxymethyl)phenyl]-1H-pyrazole
  • 4-(1H-Pyrazol-1-yl)benzyl alcohol
  • 1-[4-Hydroxymethyl)phenyl]pyrazole
  • 4-(1H-pyrazol-1-yl)-benzenemethanol
  • CPD2800-A2
  • Benzenemethanol, 4-(1H-pyrazol-1-yl)-
  • 143426-49-7
  • Pyrazole series
  • Alcohols and Derivatives
  • Heterocycles