ChemicalBook > CAS DataBase List > Lercanidipine

Lercanidipine

Product Name
Lercanidipine
CAS No.
100427-26-7
Chemical Name
Lercanidipine
Synonyms
Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);Lercanidipine, 10 mM in DMSO;methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CBNumber
CB4133658
Molecular Formula
C36H41N3O6
Formula Weight
611.73
MOL File
100427-26-7.mol
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Lercanidipine Property

Melting point:
118-120°C
Boiling point:
712.5±60.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
8.66±0.50(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
100427-26-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B3483
Product name
Lercanidipine
Packaging
10mg
Price
$87
Updated
2021/12/16
AK Scientific
Product number
M617
Product name
Lercanidipine
Packaging
25mg
Price
$98
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003147
Product name
LERCANIDIPINE
Purity
95.00%
Packaging
25MG
Price
$252
Updated
2021/12/16
AK Scientific
Product number
M617
Product name
Lercanidipine
Packaging
100mg
Price
$279
Updated
2021/12/16
ApexBio Technology
Product number
B3483
Product name
Lercanidipine
Packaging
50mg
Price
$308
Updated
2021/12/16
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Lercanidipine Chemical Properties,Usage,Production

Description

Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α1- and α2-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.

Originator

Recordati (Italy)

Uses

Antihypertensive compound; calcium channel blocker.

Definition

ChEBI: Lercanidipine is a diarylmethane.

brand name

Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati, Italy); Lercadip (Recordati, Italy); Lercan (Recordati, Italy); Lercapin (Recordati, Italy); Lercaton (Recordati, Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati, Italy); Renovia (Recordati, Italy); Vasodip (Recordati, Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy).

Lercanidipine Preparation Products And Raw materials

Raw materials

Preparation Products

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Lercanidipine Suppliers

Canada 1 China 116 Europe 2 Germany 2 India 10 South Korea 1 United Kingdom 5 United States 25 Global 162
LGM Pharma
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1-(800)-881-8210
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857-239-0968
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Cato Research Chemicals Inc.
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Aladdin Scientific
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View Lastest Price from Lercanidipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Lercanidipine 100427-26-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lercanidipine 100427-26-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Shaanxi Dideu Medichem Co. Ltd
Product
Lercanidipine 100427-26-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-11

100427-26-7, LercanidipineRelated Search:

Dimethyl sulfate Dimethyl carbonate Dimethyl ether Dacthal ETHANE 2,6-Lutidine Dimethyl sulfoxide Dimethyl disulfide Chlorodimethylphenylsilane Dimethyl fumarate Poly(dimethylsiloxane) 2,5-PYRIDINEDICARBOXYLIC ACID N,N-Dimethylformamide N-Ethylmethylamine Quinolinic acid Nitrendipine tert-Butyl methacrylate Lercanidipine mainring

  • LERCANIDIPINE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER
  • methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • LercanidipineC36H41N306
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester
  • Masnidipine
  • Rec-15-2375
  • LERCANIDIPINE(FORR&DONLY)
  • Lercanidipine 13C-d3
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
  • Lercanadipine
  • Lercanidipine USP/EP/BP
  • LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
  • Lercanidipine, 10 mM in DMSO
  • 100427-26-7
  • 100472-26-7
  • 132566-11-6
  • C36H41N3O6
  • Inhibitors
  • inhibitor