pristimerin

ChemicalBook > CAS DataBase List > pristimerin

Product Name: pristimerin
CAS No.: 1258-84-0
Chemical Name: pristimerin
Synonyms: pristimerin;Pristimerine;Pristimerin-RM;Celastrol-methylether;Pristimerin(NSC 99281);Celastrol methyl ester;Pristimerin - CAS 1258-84-0 - Calbiochem;3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester
CBNumber: CB41360260
Molecular Formula: C30H40O4
Formula Weight: 464.64
MOL File: 1258-84-0.mol

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pristimerin Property

Melting point:: 219.5°C
Boiling point:: 488.1°C (rough estimate)
Density: 1.0271 (rough estimate)
refractive index: 1.4800 (estimate)
storage temp.: -20°C
solubility: DMSO: ≥5mg/mL
form: Red solid
pka: 8.60±0.70(Predicted)
color: orange

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Safety

Toxicity: LD50 oral in mouse: 8gm/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0020
Product name: Pristimerin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $240
Updated: 2024/03/01

Sigma-Aldrich

Product number: 530070
Product name: Pristimerin
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 13621
Product name: Pristimerin
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 13621
Product name: Pristimerin
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL83303
Product name: Pristimerin
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $514
Updated: 2024/03/01

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pristimerin Chemical Properties,Usage,Production

Description

Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC₅₀ = 93 nM). Its actions are rapid, reversible, and noncompetitive. Pristimerin (1 μM) significantly increases 2-AG levels in isolated rat neurons, indicating that it inhibits endogenous MAGL in cultured cells. Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH).

Uses

antineoplastic, antiinflammatory

Uses

Pristimerin is a triterpenoid that inhibits tumor angiogenesis by targeting VEGFR2 activation and is known to exhibit anti-inflammatory properties.

Definition

ChEBI: Pristimerin is a carboxylic ester.

General Description

A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC₅₀ = 2.2 and 3.0 μM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC₅₀ ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC₅₀ = 93 nM).

Biological Activity

Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK α / β . Displays antitumor, anti-inflammatory and antimicrobial activities.

pristimerin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from pristimerin manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Pristimerin 1258-84-0
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-15

Shaanxi Dideu Medichem Co. Ltd

Product: Pristimerin 1258-84-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KG
Release date: 2024-08-09

Shanghai Standard Technology Co., Ltd.

Product: Pristimerin 1258-84-0
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-18

1258-84-0, pristimerinRelated Search:

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pristimerin

3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester

Celastrol-methylether

(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester

(9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester

3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester

Celastrol methyl ester

Pristimerin(NSC 99281)

Pristimerine

Pristimerin - CAS 1258-84-0 - Calbiochem

24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, methyl ester, (9β,13α,14β,20α)-

Methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate

Pristimerin-RM

1258-84-0

C30H40O4