Tetraethylammonium Chloride

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Tetraethylammonium Chloride

Product Name: Tetraethylammonium Chloride
CAS No.: 56-34-8
Chemical Name: Tetraethylammonium Chloride
Synonyms: teac;Tetraethylammonium;TEA CHLORIDE;ETAMON CHLORIDE;SKL1479;N2,2,2,2Cl;ammonium chL;Ethamon chloride;tetraethyl-ammoniuchloride;Tetraethylammonium choride
CBNumber: CB4136114
Molecular Formula: C8H20ClN
Formula Weight: 165.7
MOL File: 56-34-8.mol

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Tetraethylammonium Chloride Property

Melting point:: 39°C
Boiling point:: 273.32°C (rough estimate)
Density: 1.08
refractive index: 1.5480 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: methanol: 0.1 g/mL, clear, colorless
form: Crystalline Powder
color: white to light yellow
PH: 4.0 to 7.0(50g/L, 25℃)
Water Solubility: Soluble in water, ethanol, chloroform, or acetone
λmax: λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Sensitive: Hygroscopic
Merck: 14,9200
BRN: 3563247
Stability:: Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChIKey: YMBCJWGVCUEGHA-UHFFFAOYSA-M
CAS DataBase Reference: 56-34-8(CAS DataBase Reference)
EPA Substance Registry System: Tetraethylammonium chloride (56-34-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: BS6125000
F: 3-10
TSCA: Yes
HS Code: 29239000
Toxicity: LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 113042
Product name: Tetraethylammonium chloride hydrate
Packaging: 25g
Price: $58.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 113042
Product name: Tetraethylammonium chloride hydrate
Packaging: 100g
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: T0095
Product name: Tetraethylammonium Chloride
Purity: >98.0%(T)
Packaging: 25g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: T0095
Product name: Tetraethylammonium Chloride
Purity: >98.0%(T)
Packaging: 100g
Price: $107
Updated: 2024/03/01

Alfa Aesar

Product number: J62507
Product name: Tetraethylammonium chloride
Packaging: 25g
Price: $31.5
Updated: 2024/03/01

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Tetraethylammonium Chloride Chemical Properties,Usage,Production

Chemical Properties

Tetraethylammonium Chloride is a white crystalline powder. The solubility is 1000000 mg/L at 25 °C.

Uses

Medicine (nerve-blocking agent).

Uses

Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

Uses

Tetraethylammonium chloride (TEAC) has been used:

used for inhibition of peroxynitrite induced relaxation in rat aorta rings
as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons
for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Definition

ChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.

General Description

Visit our Sensor Applications portal to learn more.

Hazard

Tetraethylammonium Chloride is a strong irritant to the skin and eyes and may be harmful to the heart and central nervous system. Oral, intraperitoneal and intramuscular lethal dose studies in mice and rats caused drowsiness, tremors and muscle weakness; intravenous injection of 5 mg/kg in humans caused paralysis, mydriasis and ptosis.

Biological Activity

Non-selective K + channel blocker.

Biochem/physiol Actions

Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).

in vitro

tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1].

in vivo

vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2]

storage

Room temperature (desiccate)

Purification Methods

Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]

References

[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6.

Tetraethylammonium Chloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-BUTYLXANTHIC ACID POTASSIUM SALT 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 6-O-Benzylguanine

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View Lastest Price from Tetraethylammonium Chloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Tetraethylammonium Chloride 56-34-8
Price: US $25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-04-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetraethylammonium Chloride 56-34-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-30

Hebei Chuanghai Biotechnology Co,.LTD

Product: Tetraethylammonium Chloride 56-34-8
Price: US $5.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-12

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Tetraethylammonium choride

Tetraethylammonium chloride monohydrate, 99+%

Tetraethylammonium chloride ,98%

TETRAETHYLAMMONIUM CHLORIDE HYDRATE, 99 %

Tetraethylaminium·chloride

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Tetraethylammonium chloride,TEA chloride

Tetraethylammonium chloride puriss., electrochemical grade, >=99.0% (AT)

Tetraethylammonium chloride (TEA)

tetraethylazaniuM chloride

Ethanaminium, N,N,N-triethyl-, chloride (1:1)

Ethanaminium,N,N,N-triethyl-,chloride

n,n,n-triethyl-ethanaminiuchloride

n,n,n-triethylethanaminiumchloride

teac

TetraethylaMMoniuM chloride hydrate, 99% 100GR

TetraethylaMMoniuM chloride hydrate, 99% 25GR

tetraethylazaniuM dihydrochloride Manganese chloride

TetraethylaMMoniuM chlorid

Fourethyl aMMoniuM chloride

TEAC)TetraethylaMMoniuM chlo

Tetraethylammonium chloride Vetec(TM) reagent grade, 98%

N2,2,2,2Cl

Ethamon chloride

TETRAETHYLAMMONIUM CHLORIDE BIOULTRA

TETRA ETHYL AMMONIUM CHLORIDE TEACL

ammonium chL

Tetraethylammonium Chloride &gt

Tetraethylammonium chloride, 98%, for synthesis

etraethylammonium Chloride

SKL1479

Tetraethylammonium Chloride [N2,2,2,2]Cl

Tetraethylammonium chloride (6CI, 7CI)

56-34-8

C2H54NCl

NC2H54Cl

C8H20CIN

C8H20ClNxH2O

C2H54NClH2O

C8H20NCl

C8H20ClNH2O

Ammonium Salts

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