Tetraethylammonium Chloride
- Product Name
- Tetraethylammonium Chloride
- CAS No.
- 56-34-8
- Chemical Name
- Tetraethylammonium Chloride
- Synonyms
- teac;Tetraethylammonium;TEA CHLORIDE;ETAMON CHLORIDE;SKL1479;N2,2,2,2Cl;ammonium chL;Ethamon chloride;tetraethyl-ammoniuchloride;Tetraethylammonium choride
- CBNumber
- CB4136114
- Molecular Formula
- C8H20ClN
- Formula Weight
- 165.7
- MOL File
- 56-34-8.mol
Tetraethylammonium Chloride Property
- Melting point:
- 39°C
- Boiling point:
- 273.32°C (rough estimate)
- Density
- 1.08
- refractive index
- 1.5480 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- methanol: 0.1 g/mL, clear, colorless
- form
- Crystalline Powder
- color
- white to light yellow
- PH
- 4.0 to 7.0(50g/L, 25℃)
- Water Solubility
- Soluble in water, ethanol, chloroform, or acetone
- λmax
- λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03 - Sensitive
- Hygroscopic
- Merck
- 14,9200
- BRN
- 3563247
- Stability:
- Stable. Incompatible with strong oxidizing agents. Protect from moisture.
- InChIKey
- YMBCJWGVCUEGHA-UHFFFAOYSA-M
- CAS DataBase Reference
- 56-34-8(CAS DataBase Reference)
- EPA Substance Registry System
- Tetraethylammonium chloride (56-34-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- BS6125000
- F
- 3-10
- TSCA
- Yes
- HS Code
- 29239000
- Toxicity
- LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 113042
- Product name
- Tetraethylammonium chloride hydrate
- Packaging
- 25g
- Price
- $58.8
- Updated
- 2024/03/01
- Product number
- 113042
- Product name
- Tetraethylammonium chloride hydrate
- Packaging
- 100g
- Price
- $187
- Updated
- 2024/03/01
- Product number
- T0095
- Product name
- Tetraethylammonium Chloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- T0095
- Product name
- Tetraethylammonium Chloride
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $107
- Updated
- 2024/03/01
- Product number
- J62507
- Product name
- Tetraethylammonium chloride
- Packaging
- 25g
- Price
- $31.5
- Updated
- 2024/03/01
Tetraethylammonium Chloride Chemical Properties,Usage,Production
Chemical Properties
Tetraethylammonium Chloride is a white crystalline powder. The solubility is 1000000 mg/L at 25 °C.
Uses
Medicine (nerve-blocking agent).
Uses
Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.
Uses
Tetraethylammonium chloride (TEAC) has been used:
- used for inhibition of peroxynitrite induced relaxation in rat aorta rings
- as a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neurons
- for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties
Definition
ChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.
General Description
Visit our Sensor Applications portal to learn more.
Hazard
Tetraethylammonium Chloride is a strong irritant to the skin and eyes and may be harmful to the heart and central nervous system. Oral, intraperitoneal and intramuscular lethal dose studies in mice and rats caused drowsiness, tremors and muscle weakness; intravenous injection of 5 mg/kg in humans caused paralysis, mydriasis and ptosis.
Biological Activity
Non-selective K + channel blocker.
Biochem/physiol Actions
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).
in vitro
tetraethylammonium (tea) is a small ion that is thought to block open k channels by binding either to an internal or to an external site. for this reason, it has been used to probe the ion conduction pathway or pore of k channel mutants and a k channel chimera. tea blocks k+ channels at two sites, which define the inner and outer mouths of the channel pores [1].
in vivo
vasorelaxant effect of taurine can be diminished by tea in rat isolated arteries [2]
storage
Room temperature (desiccate)
Purification Methods
Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]
References
[1] taglialatela m, vandongen am, drewe ja, joho rh, brown am, kirsch ge. patterns of internal and external tetraethylammonium block in four homologous k+ channels. mol pharmacol. 1991 aug;40(2):299-307.
[2] niu lg, zhang ms, liu y, xue wx, liu db, zhang j, liang yq. vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. eur j pharmacol. 2008 feb 2;580(1-2):169-74. epub 2007 oct 25.
[3] shea pa, dunklee pe, et al. preliminary clinical investigation of tetraethylammonium chloride with particular reference to disorders of the circulatory system. calif med. 1948 sep;69(3):193-6.
Tetraethylammonium Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Tetraethylammonium Chloride Suppliers
- Tel
- --
- Fax
- --
- info@ChemPur.de
- Country
- Germany
- ProdList
- 2737
- Advantage
- 50
- Tel
- --
- Fax
- --
- ccc@merckgroup.com
- Country
- Germany
- ProdList
- 2008
- Advantage
- 58
- Tel
- --
- Fax
- --
- es@alfa.com
- Country
- Germany
- ProdList
- 5123
- Advantage
- 58
- Tel
- --
- Fax
- --
- chemos@chemos.de
- Country
- Germany
- ProdList
- 6727
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
- --
- Fax
- --
- service@applichem.de
- Country
- Germany
- ProdList
- 968
- Advantage
- 65
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- service@applichem.de
- Country
- Germany
- ProdList
- 1607
- Advantage
- 74
View Lastest Price from Tetraethylammonium Chloride manufacturers
- Product
- Tetraethylammonium Chloride 56-34-8
- Price
- US $25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-04-25
- Product
- Tetraethylammonium Chloride 56-34-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-30
- Product
- Tetraethylammonium Chloride 56-34-8
- Price
- US $5.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-12