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Amorolfine

Product Name
Amorolfine
CAS No.
78613-35-1
Chemical Name
Amorolfine
Synonyms
Loceryl;amorolfin;SYLIMARIN;Ro 14-4767;Amorolfine;Ro 14-4767/000;Ro-l4-4767/000;Amorolfine USP/EP/BP;Amorolfine Impurity 20;4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine
CBNumber
CB4137272
Molecular Formula
C21H35NO
Formula Weight
317.51
MOL File
78613-35-1.mol
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Amorolfine Property

Boiling point:
bp0.1 120°
Density 
0.924±0.06 g/cm3(Predicted)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
pka
7.33±0.10(Predicted)
color 
Colourless
InChI
InChI=1/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+
InChIKey
MQHLMHIZUIDKOO-AYHJJNSGNA-N
SMILES
N1(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@H](C)O[C@H](C)C1 |&1:17,20,r|
CAS DataBase Reference
78613-35-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A616753
Product name
Amorolfine
Packaging
40mg
Price
$910
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010235
Product name
AMOROLFINE
Purity
95.00%
Packaging
1G
Price
$752.87
Updated
2021/12/16
AvaChem
Product number
2588B
Product name
Amorolfine
Packaging
25mg
Price
$39
Updated
2021/12/16
AvaChem
Product number
2588B
Product name
Amorolfine
Packaging
100mg
Price
$49
Updated
2021/12/16
AvaChem
Product number
2588B
Product name
Amorolfine
Packaging
1g
Price
$179
Updated
2021/12/16
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Amorolfine Chemical Properties,Usage,Production

Uses

Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease.

Definition

ChEBI: A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action f squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.

Indications

For the treatment of skin infections, a 0.25 % cream preparation is applied once daily until clinical cure is achieved and then for a further 3–5d. For the treatment of nail mycoses caused by dermatophytes, yeasts, and moulds, a lacquer preparation containing 5 % amorolfine is painted onto the affected nail once or twice a week until the nail has regenerated. Treatment of onychomycoses normally needs to be continued for up to 1 year. Amorolfine is also active in the treatment of vaginal candidiasis.

Antimicrobial activity

Amorolfine is a broad-spectrum antimycotic with in vitro activity against dermatophytes, pathogenicCandida species, and a variety of pathogenic dimophic fungi such as Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii. The substance also shows some activity against various isolates of Aspergillus species.

Pharmacokinetics

Amorolfine is not absorbed after topical administration on normal skin. After application of a single vaginal tablet containing 50 mg of amorolfine, plasma concentrations between 27 and 83 ng/mL were observed.

Clinical Use

Amorolfine is the only drug in this class that is employed clinically in the treatment of human fungal infections. Amorolfine is not currently available in the United States, but it is marketed in Europe and Asia for the topical treatment of dermatophytic infections.

Amorolfine Preparation Products And Raw materials

Raw materials

Preparation Products

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Amorolfine Suppliers

Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Synches Co., Ltd.
Tel
021-53292253
Fax
021-53292253
Email
biz@synches.com
Country
China
ProdList
199
Advantage
64
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Xiamen Halosyntech Co., Ltd
Tel
0592-6688068 18106901346
Fax
0592-6686768
Email
qbl2015@halolife.cn
Country
China
ProdList
100
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
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View Lastest Price from Amorolfine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Amorolfine 78613-35-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-15
Hebei Weibang Biotechnology Co., Ltd
Product
Amorolfine 78613-35-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Qiuxian Baitai New Material Co., LTD
Product
Amorolfine 78613-35-1
Price
US $10.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-11-26

78613-35-1, AmorolfineRelated Search:


  • (+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine
  • SYLIMARIN
  • 4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine
  • Morpholine, 4-3-4-(1,1-dimethylpropyl)phenyl-2-methylpropyl-2,6-dimethyl-, (2R,6S)-rel-
  • Loceryl
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, cis-
  • Ro 14-4767
  • Ro 14-4767/000
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-
  • amorolfin
  • cis-4-[3-3[4-(1,1-Dimethylpropyl)phenyl]-2-methypropyl]-2,6-dimethylmor-pholine
  • Ro-l4-4767/000
  • Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-
  • 4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2α,6α-dimethylmorpholine
  • 4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2β,6β-dimethylmorpholine
  • Amorolfine
  • Amorolfine USP/EP/BP
  • Amorolfine Impurity 20
  • 78613-35-1
  • C21H35NO