Amorolfine

ChemicalBook > CAS DataBase List > Amorolfine

Product Name: Amorolfine
CAS No.: 78613-35-1
Chemical Name: Amorolfine
Synonyms: Loceryl;amorolfin;SYLIMARIN;Ro 14-4767;Amorolfine;Ro 14-4767/000;Ro-l4-4767/000;Amorolfine USP/EP/BP;Amorolfine Impurity 20;4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine
CBNumber: CB4137272
Molecular Formula: C21H35NO
Formula Weight: 317.51
MOL File: 78613-35-1.mol

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Amorolfine Property

Boiling point:: bp0.1 120°
Density: 0.924±0.06 g/cm3(Predicted)
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
pka: 7.33±0.10(Predicted)
color: Colourless
InChI: InChI=1/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+
InChIKey: MQHLMHIZUIDKOO-AYHJJNSGNA-N
SMILES: N1(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C[C@H](C)O[C@H](C)C1 |&1:17,20,r|
CAS DataBase Reference: 78613-35-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A616753
Product name: Amorolfine
Packaging: 40mg
Price: $910
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010235
Product name: AMOROLFINE
Purity: 95.00%
Packaging: 1G
Price: $752.87
Updated: 2021/12/16

AvaChem

Product number: 2588B
Product name: Amorolfine
Packaging: 25mg
Price: $39
Updated: 2021/12/16

AvaChem

Product number: 2588B
Product name: Amorolfine
Packaging: 100mg
Price: $49
Updated: 2021/12/16

AvaChem

Product number: 2588B
Product name: Amorolfine
Packaging: 1g
Price: $179
Updated: 2021/12/16

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Amorolfine Chemical Properties,Usage,Production

Uses

Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease.

Definition

ChEBI: A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action f squalene monooxygenase, Delta14 reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections.

Indications

For the treatment of skin infections, a 0.25 % cream preparation is applied once daily until clinical cure is achieved and then for a further 3–5d. For the treatment of nail mycoses caused by dermatophytes, yeasts, and moulds, a lacquer preparation containing 5 % amorolfine is painted onto the affected nail once or twice a week until the nail has regenerated. Treatment of onychomycoses normally needs to be continued for up to 1 year. Amorolfine is also active in the treatment of vaginal candidiasis.

Antimicrobial activity

Amorolfine is a broad-spectrum antimycotic with in vitro activity against dermatophytes, pathogenicCandida species, and a variety of pathogenic dimophic fungi such as Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii. The substance also shows some activity against various isolates of Aspergillus species.

Pharmacokinetics

Amorolfine is not absorbed after topical administration on normal skin. After application of a single vaginal tablet containing 50 mg of amorolfine, plasma concentrations between 27 and 83 ng/mL were observed.

Clinical Use

Amorolfine is the only drug in this class that is employed clinically in the treatment of human fungal infections. Amorolfine is not currently available in the United States, but it is marketed in Europe and Asia for the topical treatment of dermatophytic infections.

Amorolfine Preparation Products And Raw materials

Raw materials

Dimethylmorpholine Amorolfine

Preparation Products

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View Lastest Price from Amorolfine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Amorolfine 78613-35-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-15

Hebei Guanlang Biotechnology Co., Ltd.

Product: Amorolfine 78613-35-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-23

Qiuxian Baitai New Material Co., LTD

Product: Amorolfine 78613-35-1
Price: US $10.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-11-26

78613-35-1, AmorolfineRelated Search:

Dimethyl ether Dimethyl phthalate Amorolfine Hydrochloride Dimethyl sulfoxide Propyl butyrate 3-Methyl-2-butanone Cyclopropyl methyl ketone ETHANE Dimethyldimethoxysilane Dimethyl fumarate Dimethyl sulfide Propyl gallate Chloromethyl isopropyl carbonate DIMETHYL PHOSPHATE morpholine Amorolfine Dimethyl methylphosphonate Amorolfine

(+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine

SYLIMARIN

4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine

Morpholine, 4-3-4-(1,1-dimethylpropyl)phenyl-2-methylpropyl-2,6-dimethyl-, (2R,6S)-rel-

Loceryl

Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, cis-

Ro 14-4767

Ro 14-4767/000

Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-

amorolfin

cis-4-[3-3[4-(1，1-Dimethylpropyl)phenyl]-2-methypropyl]-2，6-dimethylmor-pholine

Ro-l4-4767/000

Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-

4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2α,6α-dimethylmorpholine

4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2β,6β-dimethylmorpholine

Amorolfine

Amorolfine USP/EP/BP

Amorolfine Impurity 20

78613-35-1

C21H35NO