bruceine A

Product Name: bruceine A
CAS No.: 25514-31-2
Chemical Name: bruceine A
Synonyms: NSC31616;Brucein A;bruceine A;NSC 310616;Dihydrobrusatol;Brucea javanica A;Bruceine A 25514-31-2;Bruceine A (Dihydrobrusatol;13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester;Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-
CBNumber: CB41382240
Molecular Formula: C26H34O11
Formula Weight: 522.54
MOL File: 25514-31-2.mol

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bruceine A Property

Boiling point:: 712.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming
form: Powder
pka: 8.81±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 25mg
Price: $420
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 29936
Product name: Bruceine A
Packaging: 10mg
Price: $214
Updated: 2024/03/01

TRC

Product number: B689315
Product name: BruceantinA
Packaging: 25mg
Price: $340
Updated: 2021/12/16

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bruceine A Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.

Uses

Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.

Definition

ChEBI: Bruceine A is a quassinoid.

Biological Activity

ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.

Physiological effects

Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.

in vitro

bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].

in vivo

oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].

target

Antifection | p65 | NF-kB | ROS

References

[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.

bruceine A Preparation Products And Raw materials

Raw materials

Preparation Products

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bruceine A Suppliers

China 108 United Kingdom 1 United States 12 Global 121

MedChemexpress LLC

Tel: 021-58955995
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ALB Technology Limited

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BOC Sciences

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Musechem

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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InvivoChem

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Protheragen-ING

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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Cayman Chemical Company

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MedChemExpress

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View Lastest Price from bruceine A manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Bruceine A 25514-31-2 25514-31-2
Price: US $160.00/mg
Min. Order: 10mg
Purity: >98% by HPLC
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

Career Henan Chemical Co

Product: bruceine A 25514-31-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

25514-31-2, bruceine ARelated Search:

YADANZIOSIDE-L bruceine B Acid Red 94 DEHYDROBRUCEANTIN Bruceantin (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione bruceine E brusatol yadanziolide A YADANZIOLIDE-C (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione bruceine D Brucea javanicaseed oil Bruceae Fructus

bruceine A

13,20-Epoxy-3,11β,12α-trihydroxy-15β-(3-methyl-1-oxobutoxy)-2,16-dioxopicras-3-en-21-oic acid methyl ester

Dihydrobrusatol

NSC 310616

Bruceine A (Dihydrobrusatol

Bruceine A 25514-31-2

Brucea javanica A

NSC31616

Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,15β)-

Brucein A

25514-31-2

C26H34O11