ChemicalBook > CAS DataBase List > YS 49

YS 49

Product Name
YS 49
CAS No.
132836-42-1
Chemical Name
YS 49
Synonyms
YS 49;CS-884;YS 49;YS49;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
CBNumber
CB41390234
Molecular Formula
C20H20BrNO2
Formula Weight
386.2823
MOL File
132836-42-1.mol
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YS 49 Property

storage temp. 
2-8°C
solubility 
H2O: >10mg/mL
form 
solid
color 
White to off-white
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y1521
Product name
YS-49 monohydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$213
Updated
2022/05/15
Axon Medchem
Product number
Axon1685
Product name
YS49
Purity
98%
Packaging
10mg
Price
$148.5
Updated
2021/12/16
AK Scientific
Product number
3028AH
Product name
1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolhydrobromide
Packaging
1mg
Price
$152
Updated
2021/12/16
ChemScene
Product number
CS-1002
Product name
YS-49
Purity
95.38%
Packaging
10mg
Price
$158
Updated
2021/12/16
ChemScene
Product number
CS-2288
Product name
YS-49 monohydrate
Purity
>98.0%
Packaging
10mg
Price
$158
Updated
2021/12/16
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YS 49 Chemical Properties,Usage,Production

Biological Activity

YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.

in vitro

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells)
Incubation Time: 18 hours
Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively .

Western Blot Analysis

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μΜ, 30 μΜ and 100 μΜ
Incubation Time: 18 hours
Result: Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

in vivo

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>

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Animal Model: Male Sprague Dawley rats (250-300 g)
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 8 hours
Result: Serum NOx levels were significantly reduced.

YS 49 Preparation Products And Raw materials

Raw materials

Preparation Products

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YS 49 Suppliers

China 63 United States 12 Global 75
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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4660
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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United States
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
Country
United States
ProdList
6391
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
TargetMol Chemicals Inc.
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Email
support@targetmol.com
Country
United States
ProdList
38632
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58
Riedel-de Haen AG
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BOC Sciences
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16314854226
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Cayman Chemical Company
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MedChemExpress
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Axon Medchem LLC
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NE Scientific
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132836-42-1, YS 49Related Search:

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  • YS 49
  • 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
  • 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide
  • CS-884
  • YS 49;YS49
  • inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
  • 132836-42-1
  • C20H19NO2HBr
  • Akt
  • mTOR
  • PI3K
  • PI3K/Akt/mTOR