6-Chloroguanine
Description- Product Name
- 6-Chloroguanine
- CAS No.
- 10310-21-1
- Chemical Name
- 6-Chloroguanine
- Synonyms
- 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;6-CHLORO-2-AMINOPURINE;2-amino-6-chloro-purin;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-Amino-6-chloropuri
- CBNumber
- CB4143631
- Molecular Formula
- C5H4ClN5
- Formula Weight
- 169.57
- MOL File
- 10310-21-1.mol
6-Chloroguanine Property
- Melting point:
- >300 °C (lit.)
- Boiling point:
- 279.76°C (rough estimate)
- Density
- 1.4937 (rough estimate)
- refractive index
- 1.6110 (estimate)
- storage temp.
- 2-8°C
- solubility
- Solubility in 1mol/L NaOH
- form
- Powder
- pka
- 6.65±0.20(Predicted)
- color
- White to yellow
- Water Solubility
- 1.7 g/L (20 ºC)
- BRN
- 9626
- InChI
- InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
- InChIKey
- RYYIULNRIVUMTQ-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(N)=NC=2Cl)NC=1
- CAS DataBase Reference
- 10310-21-1(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Chloro-2-aminopurine (10310-21-1)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- UO7502000
- F
- 10
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- PHR2861
- Product name
- Famciclovir Related Compound F
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 109789
- Product name
- 2-Amino-6-chloropurine
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 109789
- Product name
- 2-Amino-6-chloropurine
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $31.2
- Updated
- 2024/03/01
- Product number
- A1407
- Product name
- 2-Amino-6-chloropurine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- A1407
- Product name
- 2-Amino-6-chloropurine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $101
- Updated
- 2024/03/01
6-Chloroguanine Chemical Properties,Usage,Production
Description
6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.
Description
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).
Chemical Properties
white to light yellow crystal powder
Uses
2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
Uses
2-Amino-6-chloropurine may be used:
- in the enzymatic synthesis of 2′-deoxyguanosine
- in the synthesis of 9-alkyl purines
- in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
Definition
ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.
General Description
2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.
Synthesis
Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).
6-Chloroguanine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloroguanine Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3576
- Advantage
- 66
- Tel
- +49 4241 9308 88
- Fax
- +49 4241 9308 89
- info@beckmann-kenko.com
- Country
- Germany
- ProdList
- 479
- Advantage
- 62
View Lastest Price from 6-Chloroguanine manufacturers
- Product
- 6-Chloroguanine 10310-21-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 100g/Bag
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2020-09-16
- Product
- 2-Amino-6-chloropurine 10310-21-1
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
- Product
- 2-Amino-6-chloropurine 10310-21-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-03-19