6-Chloroguanine

Description

Product Name: 6-Chloroguanine
CAS No.: 10310-21-1
Chemical Name: 6-Chloroguanine
Synonyms: 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;6-CHLORO-2-AMINOPURINE;2-amino-6-chloro-purin;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-Amino-6-chloropuri
CBNumber: CB4143631
Molecular Formula: C5H4ClN5
Formula Weight: 169.57
MOL File: 10310-21-1.mol

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6-Chloroguanine Property

Melting point:: >300 °C (lit.)
Boiling point:: 279.76°C (rough estimate)
Density: 1.4937 (rough estimate)
refractive index: 1.6110 (estimate)
storage temp.: 2-8°C
solubility: Solubility in 1mol/L NaOH
form: Powder
pka: 6.65±0.20(Predicted)
color: White to yellow
Water Solubility: 1.7 g/L (20 ºC)
BRN: 9626
InChI: InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey: RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES: N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference: 10310-21-1(CAS DataBase Reference)
EPA Substance Registry System: 6-Chloro-2-aminopurine (10310-21-1)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: UO7502000
F: 10
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2861
Product name: Famciclovir Related Compound F
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: 109789
Product name: 2-Amino-6-chloropurine
Purity: ≥99%
Packaging: 1g
Price: $26
Updated: 2024/03/01

Sigma-Aldrich

Product number: 109789
Product name: 2-Amino-6-chloropurine
Purity: ≥99%
Packaging: 5g
Price: $31.2
Updated: 2024/03/01

TCI Chemical

Product number: A1407
Product name: 2-Amino-6-chloropurine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: A1407
Product name: 2-Amino-6-chloropurine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $101
Updated: 2024/03/01

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6-Chloroguanine Chemical Properties,Usage,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Uses

2-Amino-6-chloropurine may be used:

in the enzymatic synthesis of 2′-deoxyguanosine
in the synthesis of 9-alkyl purines
in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

6-Chloroguanine Preparation Products And Raw materials

Raw materials

Guanine 2,4,5-Triamino-6-chloropyrimidine

Preparation Products

Famciclovir Ganciclovir 6-Thioguanine Penciclovir 6-O-Benzylguanine 2-Amino-6-iodopurine

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6-Chloroguanine Suppliers

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Clearsynth Labs Limited

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View Lastest Price from 6-Chloroguanine manufacturers

Jinan Finer Chemical Co., Ltd

Product: 6-Chloroguanine 10310-21-1
Price: US $0.00/Kg/Drum
Min. Order: 100g/Bag
Purity: 99%
Supply Ability: 100mt/year
Release date: 2020-09-16

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 2-Amino-6-chloropurine 10310-21-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-12-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 6-Chloroguanine 10310-21-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-18

10310-21-1, 6-ChloroguanineRelated Search:

2-Amino-4-chloro-6-methoxypyrimidine 4,6-Dimethoxy-2-methylthiopyrimidine 2-Amino-4,6-dimethylpyrimidine 6-Chloroguanine 6-CHLOROGUANINE RIBOSIDE,6-Chloroguanine nucleoside,(-)-2-Amino-6-chloropurine riboside, 6-Chloroguanine riboside 9-(4-Acetoxy-3-acetoxymethylbutyl)-2-amino-6-chloropurine 8-CHLOROGUANINE,CHLOROGUANINE 2-Aminopurine Purine 6-Chloropurine 6-Methoxypurine 2-ACETAMIDO-6-CHLOROPURINE 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE 2-AMINO-6-CHLORO-9-(3,5-DI-O-(P-TOLUOYL)-BETA-D-2-DEOXYRIBOFURNANOSYL)PURINE 2-AMINO-6-CHLORO-9H-PURINE-9-ACETIC ACID 9-(4-ACETOXY-3-ACETOXYMETHYLBUTYL)-2-AMINO-6-CHLOROPURINE-D4 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE

Clofarabine Impurity 3

AURORA KA-689

2-amino-6-chloro-purin

2-AMINO-6-CHLOROPURINE

6-CHLORO-2-AMINOPURINE

6-CHLORO-9H-PURIN-2-YLAMINE

6-CHLOROGUANINE

6-Chloro-7H-purin-2-ylamine

TIMTEC-BB SBB003863

6-Chloro-2-purinamine

6-Chloro-7H-purine-2-amine

2-AMINO-6-CHLOROPURINE (2A6ClP)

2-Amino-6-chloropuri

6-chloro-9H-purin-2-amine(SALTDATA: FREE)

2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile

2-AMino-6-chlorpurin

FaMciclovir Related CoMpound F

2-AMino-6-chloropurine, 98+%

2 - aMino - 6 - chlorine purine

Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine)

1H-Purin-2-amine, 6-chloro- (9CI)

2-Amino-6-chlorpurine

Purine, 2-amino-6-chloro-

6-chloro-1h-purin-2-amin

6-chloro-1h-purin-2-amine

FAMCICLOVIR INTERMEDIATES

9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine

2-Amino-6-chloro-9H-purine

6-CHLOROGUANINE CRYSTALLINE

2-Amino-6-Chloropurine(6-Chloroguanine)

1H-Purin-2-amine, 6-chloro-

2-Amino-6-chloro-9H-purine 99%

9H-PURIN-2-AMINE, 6-CHLORO-

6-CHLOROGUANINE extrapure

6-Chloro-7H-purin-2-amine

4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine

2-Amino-6-chloropurine &gt

2-Amino-6-Chloro-Purin,>98%

Famciclovir USP RC F

6-Chloroguanine USP/EP/BP

Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141)

Famciclovir USP Related Compound F

2-Amino-6-c2-Amino-6-chloropurinehloropurine

Famciclovir Related Compound F (2-Amino-6-chloropurine)

Entecavir Impurity 43

10310-21-1

10310-21-2

233-686-7

C5H4CIN5

C5H4ClN2

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Purines

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Nucleic acids