ChemicalBook > CAS DataBase List > 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid

Product Name
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
CAS No.
5471-77-2
Chemical Name
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
Synonyms
NSC 28452;DiMethylMalonic Acid Monoethyl Ester;3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid;3-ethoxy-3-keto-2,2-dimethyl-propionic acid;3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid-13;Propanedioic acid, 2,2-dimethyl-, 1-ethyl ester;propanedioic acid, 2,2-dimethyl-, monoethyl ester
CBNumber
CB41481909
Molecular Formula
C7H12O4
Formula Weight
160.17
MOL File
5471-77-2.mol
More
Less

3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Property

Boiling point:
101-102 °C(Press: 0.5 Torr)
Density 
1.126±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.00±0.36(Predicted)
Appearance
Colorless to off-white Solid-liquid mixture
InChI
InChI=1S/C7H12O4/c1-4-11-6(10)7(2,3)5(8)9/h4H2,1-3H3,(H,8,9)
InChIKey
WDWFSABLPAHCPF-UHFFFAOYSA-N
SMILES
C(OCC)(=O)C(C)(C)C(O)=O
More
Less

Safety

HS Code 
2917198090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
E893045
Product name
3-Ethoxy-2,2-dimethyl-3-oxopropanoicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
072886
Product name
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
Purity
95+%
Packaging
500mg
Price
$70
Updated
2021/12/16
AK Scientific
Product number
W6894
Product name
3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid
Packaging
250mg
Price
$128
Updated
2021/12/16
Apolloscientific
Product number
OR321466
Product name
3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid
Purity
97%
Packaging
1g
Price
$145
Updated
2021/12/16
AK Scientific
Product number
W6894
Product name
3-Ethoxy-2,2-dimethyl-3-oxopropanoicacid
Packaging
1g
Price
$145
Updated
2021/12/16
More
Less

3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 2721, 1974 DOI: 10.1016/S0040-4039(01)91723-X

Synthesis

1619-62-1

5471-77-2

General procedure for the synthesis of monoethyl 2,2-dimethylmalonate from diethyl 2,2-dimethylmalonate: potassium hydroxide (7.5 g, 131.5 mmol) was added to a solution of diethyl 2,2-dimethylmalonate (25.0 g, 132.8 mmol) in ethanol (100.0 mL). The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water and extracted with ether. The aqueous phase was acidified to pH 4 with aqueous 6N hydrochloric acid and subsequently extracted with ethyl acetate. The ethyl acetate extracts were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give 17.0 g of monoethyl 2,2-dimethylmalonate as an orange liquid. Yield: 80%; MS data: m/z 161 [M + H]+.

References

[1] Patent: WO2007/20936, 2007, A1. Location in patent: Page/Page column 114-115
[2] Patent: US2011/71196, 2011, A1. Location in patent: Page/Page column 31
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6790 - 6802
[4] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 101; 102
[5] Helvetica Chimica Acta, 1935, vol. 18, p. 1279

3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid Suppliers

China 61 Germany 1 India 2 United States 8 Global 72
Changzhou Liren Medical Technology Co. Ltd.
Tel
0519-85859058 13915836899
Email
2078957504@qq.com
Country
China
ProdList
358
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
ChangZhou SIDU chemical Co., Ltd.
Tel
0519-81291281 18015082300
Fax
0519-81291281
Email
siduchem@hotmail.com
Country
China
ProdList
274
Advantage
62
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3764
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Leto Pharmatech Co.,Ltd.
Tel
18016401466
Fax
QQ: 1375988926
Email
sales@letopharm.com
Country
China
ProdList
245
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Mashilabs (Shanghai) Co.,Ltd.
Tel
19916721580
Fax
QQ：3154870176
Email
mafarm@126.com
Country
China
ProdList
4542
Advantage
58
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4895
Advantage
55
Zhengzhou Alfachem Co.,Ltd.
Tel
0371-53778726 18003825608
Fax
QQ：2885354392
Email
liuxiaoyan@alfachem.cn
Country
China
ProdList
1987
Advantage
58
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Nanjing Hengbei Chemicals Co., Ltd.
Tel
+86-25-58393656
Fax
+86-25-58393656
Email
sales@hengbeichem.cn
Country
China
ProdList
6854
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Zhengzhou Edward Biology Co.,Ltd
Tel
0371-63682289 15538176268
Fax
QQ：1875164801
Email
jacschem@163.com
Country
China
ProdList
9926
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shanghai Boyi Biomedical Technology Co., Ltd.
Tel
021-021-54331997 18321536537
Email
info@ansionpharma.com
Country
China
ProdList
2336
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 +86-17392581500
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3987
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002 18367600069;
Email
zhejia01@163.com
Country
China
ProdList
8887
Advantage
58
Henan Dobe Chemical Co. , Ltd.
Tel
0370-6999054 17550096163
Email
3189729795@qq.com
Country
China
ProdList
7172
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Anyang Hongmeng New Materials Co., Ltd
Tel
0372-19588588067 19588588067
Email
19588588067@163.com
Country
China
ProdList
2393
Advantage
58
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281
Email
1522334715@qq.com
Country
China
ProdList
7507
Advantage
58
Tianjin Rongshen Chemical Co., Ltd
Tel
18317763565; 18317763565
Email
18317763565@163.com
Country
China
ProdList
9516
Advantage
58
Shanghai Hansi Chemical Industry Co., Ltd.
Tel
17717618050
Email
zllg@gh-reagent.com
Country
China
ProdList
10420
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
14580
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Email
sales@coreychem.com
Country
China
ProdList
29846
Advantage
58
Nanjing ChemLin Chemical Industry Co., Ltd.
Tel
025-83697070
Email
product@chemlin.com.cn
Country
CHINA
ProdList
3009
Advantage
60
Hebei Chuanghai Biotechnology Co., Ltd
Tel
+86-15350571055
Email
Sibel@chuanghaibio.com
Country
China
ProdList
6085
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+86-512-68323658 +86-18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39002
Advantage
58
Changzhou AniKare Pharmatech Co., Ltd.
Tel
+86-0519-8359-8696 +8618018249389
Email
sales@anikare.com
Country
China
ProdList
9941
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49934
Advantage
58
PT CHEM GROUP LIMITED
Tel
+86-85511178;
Email
peter68@ptchemgroup.com
Country
China
ProdList
35425
Advantage
58
Hebei Shengyuan Jinlong Import and Export Co. LTD
Tel
+8617367750398
Email
info@hebeisyjl.com
Country
China
ProdList
1838
Advantage
58
Henan Aochuang Chemical Co.,Ltd.
Tel
+86-0371-63689365 +8618638391208
Email
sales@aochuangchem.com
Country
China
ProdList
9307
Advantage
58
changzhou huayang technology co., ltd
Tel
+8615250961469
Email
2571773637@qq.com
Country
China
ProdList
9644
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
--
Fax
--
Email
sales@sunwaypharm.com
Country
China
ProdList
6536
Advantage
58
More
Less

View Lastest Price from 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid 5471-77-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Hebei Mingeng Biotechnology Co., Ltd
Product
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid 5471-77-2
Price
US $200.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
500kg/month
Release date
2022-05-05
Career Henan Chemical Co
Product
3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid 5471-77-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2019-08-30

5471-77-2, 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acidRelated Search:

Ethyl malonyl chloride Diethyl methylmalonate MONO-ETHYL SUCCINATE Dimethyl sulfoxide Ethyl hydrogen malonate DIETHYL DIMETHYLMALONATE DIETHYL BROMOMALONATE Dimethyl sebacate Diethyl ethylmalonate Diethyl malonate Dimethyl carbonate Dimethyl malonate Ethyl potassium malonate Ethyl Succinyl Chloride ETHANE Malonic acid N,N-Dimethylformamide Dimethyl fumarate

  • 3-ethoxy-3-keto-2,2-dimethyl-propionic acid
  • DiMethylMalonic Acid Monoethyl Ester
  • 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid-13
  • NSC 28452
  • 3-Ethoxy-2,2-dimethyl-3-oxopropanoic acid
  • propanedioic acid, 2,2-dimethyl-, monoethyl ester
  • Propanedioic acid, 2,2-dimethyl-, 1-ethyl ester
  • 5471-77-2