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2-Methyl-3-nitropyridine

Product Name
2-Methyl-3-nitropyridine
CAS No.
18699-87-1
Chemical Name
2-Methyl-3-nitropyridine
Synonyms
3-NITROPICOLINE;3-NITRO-2-PICOLINE;2-Methyl-3-nitropyri;2-METHYL-3-NITROPYRIDINE;3-NITRO-2-METHYLPYRIDINE;2-Methxy-3-nitropyridine;Pyridine, 2-Methyl-3-nitro-;2-METHYL-3-NITROPYRIDINE 95%;Pyridine, 2-methyl-3-nitro- (9CI);2-Methyl-3-nitropyridine ISO 9001:2015 REACH
CBNumber
CB4150688
Molecular Formula
C6H6N2O2
Formula Weight
138.12
MOL File
18699-87-1.mol
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2-Methyl-3-nitropyridine Property

Melting point:
32-33°
Boiling point:
86°C/5mmHg(lit.)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Methanol
form 
powder to lump
pka
1.92±0.10(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C6H6N2O2/c1-5-6(8(9)10)3-2-4-7-5/h2-4H,1H3
InChIKey
CCFGTKQIRWHYTB-UHFFFAOYSA-N
SMILES
C1(C)=NC=CC=C1[N+]([O-])=O
CAS DataBase Reference
18699-87-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2548
Product name
2-Methyl-3-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
M2548
Product name
2-Methyl-3-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$93
Updated
2024/03/01
TRC
Product number
M320425
Product name
2-Methyl-3-nitropyridine
Packaging
1g
Price
$120
Updated
2021/12/16
SynQuest Laboratories
Product number
4H55-1-67
Product name
2-Methyl-3-nitropyridine
Packaging
25g
Price
$200
Updated
2021/12/16
SynQuest Laboratories
Product number
4H55-1-67
Product name
2-Methyl-3-nitropyridine
Packaging
5G
Price
$60
Updated
2021/12/16
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2-Methyl-3-nitropyridine Chemical Properties,Usage,Production

Uses

2-Methyl-3-nitropyridine is used as a starting reagent to synthesize 3-substituted-4 or 6-azaindoles, and is also used as a reagent to prepare 3-azaindolyl-4-arylmalemides (compounds that exhibit antiproliferative activity).

Reactions

2-Methyl-3-nitropyridine could be used to synthesize dichloro-(3-nitro-2-pyridyl)methylphosphonic dichloride. The chlorination of 2-methyl-3-nitropyridine using a mixture of PCl5 in POCl3[1].

Synthesis Reference(s)

Tetrahedron, 54, p. 6311, 1998 DOI: 10.1016/S0040-4020(98)00328-7
Journal of Heterocyclic Chemistry, 29, p. 359, 1992 DOI: 10.1002/jhet.5570290213
Synthetic Communications, 20, p. 2965, 1990 DOI: 10.1080/00397919008051513

Synthesis

Suzuki Reaction. A mixture of 2-chloro-3-nitro-pyridine 1 (793 mg, 5 mmol), methylboronic acid (329 mg, 5.5 mmol), Pd(PPh3) 4 (578 mg, 0.5 mmol) and K2CO 3 (2.073 g, 15 retool) in dioxane (25 mL) was refluxed for 2 days, then cooled to room temperature and filtered. The solvent was removed and the residue was isolated by chromatography (hexanes-EtOAc = 1:1) to provide 623 mg (90%) of 2-methyl-3-nitropyridine[2].

References

[1] Amrane D, et al. "Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride." Molbank (2022).
[2] Niu, Chuansheng , et al. "Synthesis of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)." 54.23(1998):6311-6318.

2-Methyl-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-3-nitropyridine Suppliers

TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
CHEMSTEP
Tel
--
Fax
--
Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
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View Lastest Price from 2-Methyl-3-nitropyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Methyl-3-nitropyridine 18699-87-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22
Dideu Industries Group Limited
Product
2-Methyl-3-nitropyridine 18699-87-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-08
Career Henan Chemical Co
Product
2-Methyl-3-nitropyridine 18699-87-1
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-03

18699-87-1, 2-Methyl-3-nitropyridineRelated Search:


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  • 3-Nitro-2-methylpyridine 3-Nitro-2-picoline
  • 2-METHYL-3-NITROPYRIDINE 95%
  • 3-NITROPICOLINE
  • Pyridine, 2-Methyl-3-nitro-
  • 2-Methyl-3-nitropyridine ISO 9001:2015 REACH
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