2-Methyl-3-nitropyridine
- Product Name
- 2-Methyl-3-nitropyridine
- CAS No.
- 18699-87-1
- Chemical Name
- 2-Methyl-3-nitropyridine
- Synonyms
- 3-NITROPICOLINE;3-NITRO-2-PICOLINE;2-Methyl-3-nitropyri;2-METHYL-3-NITROPYRIDINE;3-NITRO-2-METHYLPYRIDINE;2-Methxy-3-nitropyridine;Pyridine, 2-Methyl-3-nitro-;2-METHYL-3-NITROPYRIDINE 95%;Pyridine, 2-methyl-3-nitro- (9CI);2-Methyl-3-nitropyridine ISO 9001：2015 REACH
- CBNumber
- CB4150688
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 18699-87-1.mol
2-Methyl-3-nitropyridine Property
- Melting point:
- 32-33°
- Boiling point:
- 86°C/5mmHg(lit.)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to lump
- pka
- 1.92±0.10(Predicted)
- color
- Light yellow to Brown
- InChI
- InChI=1S/C6H6N2O2/c1-5-6(8(9)10)3-2-4-7-5/h2-4H,1H3
- InChIKey
- CCFGTKQIRWHYTB-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 18699-87-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2548
- Product name
- 2-Methyl-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $31
- Updated
- 2024/03/01
- Product number
- M2548
- Product name
- 2-Methyl-3-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- M320425
- Product name
- 2-Methyl-3-nitropyridine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- U870
- Product name
- 2-Methyl-3-nitropyridine
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 046603
- Product name
- 2-Methyl-3-nitropyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $24
- Updated
- 2021/12/16
2-Methyl-3-nitropyridine Chemical Properties,Usage,Production
Uses
2-Methyl-3-nitropyridine is used as a starting reagent to synthesize 3-substituted-4 or 6-azaindoles, and is also used as a reagent to prepare 3-azaindolyl-4-arylmalemides (compounds that exhibit antiproliferative activity).
Reactions
2-Methyl-3-nitropyridine could be used to synthesize dichloro-(3-nitro-2-pyridyl)methylphosphonic dichloride. The chlorination of 2-methyl-3-nitropyridine using a mixture of PCl5 in POCl3[1].
Synthesis Reference(s)
Tetrahedron, 54, p. 6311, 1998 DOI: 10.1016/S0040-4020(98)00328-7
Journal of Heterocyclic Chemistry, 29, p. 359, 1992 DOI: 10.1002/jhet.5570290213
Synthetic Communications, 20, p. 2965, 1990 DOI: 10.1080/00397919008051513
Synthesis
Suzuki Reaction. A mixture of 2-chloro-3-nitro-pyridine 1 (793 mg, 5 mmol), methylboronic acid (329 mg, 5.5 mmol), Pd(PPh3) 4 (578 mg, 0.5 mmol) and K2CO 3 (2.073 g, 15 retool) in dioxane (25 mL) was refluxed for 2 days, then cooled to room temperature and filtered. The solvent was removed and the residue was isolated by chromatography (hexanes-EtOAc = 1:1) to provide 623 mg (90%) of 2-methyl-3-nitropyridine[2].
References
[1] Amrane D, et al. "Dichloro{4-(4-chlorophenoxy)phthalazin-1-yl} methylphosphonic dichloride." Molbank (2022).
[2] Niu, Chuansheng , et al. "Synthesis of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP)." 54.23(1998):6311-6318.
2-Methyl-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyl-3-nitropyridine manufacturers
- Product
- 2-Methyl-3-nitropyridine 18699-87-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 2-Methyl-3-nitropyridine 18699-87-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-08
- Product
- 2-Methyl-3-nitropyridine 18699-87-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-08-03