ChemicalBook > CAS DataBase List > N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol

N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol

Product Name
N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol
CAS No.
82689-20-1
Chemical Name
N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol
Synonyms
Boc-K(Z)-OL;Boc-L-Lys(Z)-ol;Boc-Lys(Cbz)-Ol;Boc-L-Lysinol(Z);Boc-L-Lys(Cbz)-OL;Boc-Lysinol(Z)-OH;N-BOC-N'-CBZ-lysine;Na-Boc-Ne-Z-L-lysinol≥ 98% (HPLC);N-alpha-Boc-N-epsilon-Cbz-L-lysinol;(S)-Benzyl tert-butyl (6-hydroxyhexane-1,5-diyl)dicarbaMate
CBNumber
CB41511068
Molecular Formula
C19H30N2O5
Formula Weight
366.45
MOL File
82689-20-1.mol
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N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Property

Melting point:
62-63℃
Boiling point:
551.4±50.0 °C(Predicted)
Density 
1.122±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.06±0.46(Predicted)
InChI
InChI=1S/C19H30N2O5/c1-19(2,3)26-18(24)21-16(13-22)11-7-8-12-20-17(23)25-14-15-9-5-4-6-10-15/h4-6,9-10,16,22H,7-8,11-14H2,1-3H3,(H,20,23)(H,21,24)/t16-/m0/s1
InChIKey
MLAPMZGXJGUYNO-INIZCTEOSA-N
SMILES
C(OCC1=CC=CC=C1)(=O)NCCCC[C@H](NC(OC(C)(C)C)=O)CO
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B656925
Product name
Boc-Lysinol(Z)
Packaging
5g
Price
$330
Updated
2021/12/16
Chem-Impex
Product number
03200
Product name
Nα-Boc-Nε-Z-L-lysinol,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$39.2
Updated
2021/12/16
AK Scientific
Product number
2779AC
Product name
Boc-L-Lys(Z)-ol
Packaging
1g
Price
$47
Updated
2021/12/16
Chem-Impex
Product number
03200
Product name
Nα-Boc-Nε-Z-L-lysinol,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$162.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
AAA0002467
Product name
BOC-L-LYSINOL(Z)
Purity
95.00%
Packaging
5MG
Price
$495.92
Updated
2021/12/16
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N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc-Lysinol(Z) is used to prepare N-(iminoethyl)lysinol derivs. as nitric oxide synthase inhibitors.

Synthesis

2389-45-9

82689-20-1

GENERAL METHODS: To a solution of N-Boc-N'-Cbz-L-lysine (10 mmol) in THF (10 mL) was added DIPEA (11 mmol, 1.42 mL) and EtOAc solution of 50% T3P (20 mmol, 6.36 mL) at 0 °C with stirring for about 10 min. Then NaBH4 aqueous solution (10 mmol, 388 mg, dissolved in 0.3 mL H2O) was slowly added to the reaction mixture at the same temperature, and the progress of the reaction was monitored by TLC until the reaction was completed. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the crude product was extracted with EtOAc. The organic phase was washed sequentially with 5% aqueous citric acid (10 mL × 2), 5% aqueous Na2CO3 (10 mL × 2), water and saturated saline. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give (S)-tert-butylbenzyl (6-hydroxyhexane-1,5-diyl) dicarbamate.

References

[1] Tetrahedron Asymmetry, 2015, vol. 26, # 21-22, p. 1273 - 1280
[2] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5059 - 5063
[3] Synlett, 1999, # 8, p. 1239 - 1240
[4] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 5, p. 1921 - 1924
[5] Tetrahedron Letters, 1991, vol. 32, # 7, p. 923 - 926

N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Lys(Cbz)-Ol 82689-20-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-17
Career Henan Chemical Co
Product
N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol 82689-20-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10tons
Release date
2020-02-18
Sichuan Jiaying Lai Technology Co.,LTD
Product
Boc-Lys(Cbz)-Ol 82689-20-1
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-21

82689-20-1, N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinolRelated Search:

N-Boc-N'-Cbz-L-lysine Boc-His(Trt)-OH Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine BOC-LYS(Z)-OH DCHA BOC-LYS(Z)(ISOPROPYL)-OH BOC-LYS(Z)-OSU BOC-LYS(2-CHLORO-Z)-OH T-BUTYLAMINE NALPHA-(T-BUTOXYCARBONYL)-N-EPS-(CARBOB& BOC-L-LYS(2-CL-Z)-O-CH2-PHI-CH2-COOH BOC-LYS(4-NITRO-Z)-OH BOC-LYS(2-CHLORO-Z)-OSU BOC-L-MELYS(Z)-OH BOC-LYS(2-BROMO-Z)-OH N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol N-α-Boc-N-ε-Z-L-lysine N-carboxyanhydride BOC-LYS(2-CL-Z)-OL

  • (S)-Benzyl tert-butyl (6-hydroxyhexane-1,5-diyl)dicarbaMate
  • N-alpha-Boc-N-epsilon-Cbz-L-lysinol
  • Boc-L-Lys(Z)-ol
  • N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol
  • Boc-Lysinol(Z)-OH
  • Benzyl [(5S)-5-[[(tert-butyloxy)carbonyl]amino]-6-hydroxyhexyl]carbamate
  • Boc-L-Lysinol(Z)
  • Boc-L-Lys(Cbz)-OL
  • Na-Boc-Ne-Z-L-lysinol≥ 98% (HPLC)
  • Boc-Lys(Cbz)-Ol
  • Benzyl [(5S)-5-[[(tert-butyloxy)carbonyl]amino]-6-hydroxyhex
  • Boc-K(Z)-OL
  • Carbamic acid, N-[(5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-hydroxyhexyl]-, phenylmethyl ester
  • Benzyl tert-butyl (6-hydroxyhexane-1,5-diyl)(S)-dicarbamate
  • N-BOC-N'-CBZ-lysine
  • 82689-20-1
  • Amino Acids