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CEPHALEXIN MONOHYDRATE

Product Name
CEPHALEXIN MONOHYDRATE
CAS No.
23325-78-2
Chemical Name
CEPHALEXIN MONOHYDRATE
Synonyms
KEFLEX;CEFALEXIN HYDRATE;CEPHALEXIN HYDRATE;Cephalexin (400 mg);cefalexin monohydrat;Cefalexin(coMpacted);Cephalexin (1099008);CEPHALEXIN 1-HYDRATE;CEFALEXIN MONOHYDRATE;CEPHALEXIN MONOHYDRATE
CBNumber
CB4153386
Molecular Formula
C16H19N3O5S
Formula Weight
365.4
MOL File
23325-78-2.mol
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CEPHALEXIN MONOHYDRATE Property

Melting point:
>161°C (dec.)
refractive index 
154 ° (C=0.5, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
NH4OH 1 M: 50 mg/mL, clear, yellow
form 
solid
color 
White to Light Beige
Water Solubility 
13.5g/L(25 ºC)
Merck 
14,1974
BRN 
965503
Stability:
Unstable in Solution
InChIKey
AVGYWQBCYZHHPN-KJTIIWGRSA-N
CAS DataBase Reference
23325-78-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-45-24/25
WGK Germany 
3
RTECS 
XI0350000
HS Code 
29419052
Toxicity
LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0675000
Product name
Cephalexin monohydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
c0675000
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
1099008
Product name
Cephalexin
Packaging
400mg
Price
$436
Updated
2024/03/01
Usbiological
Product number
257237
Product name
Cephalexin hydrate
Packaging
100g
Price
$355
Updated
2021/12/16
AK Scientific
Product number
3535AH
Product name
Cephalexinmonohydrochloride
Packaging
25g
Price
$392
Updated
2021/12/16
Chem-Impex
Product number
38384
Product name
Cephalexinmonohydrate,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
25G
Price
$292.36
Updated
2021/12/16
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CEPHALEXIN MONOHYDRATE Chemical Properties,Usage,Production

Description

Cephalexin was first synthesized in 1967 by Glaxo Research Laboratories and first produced on an industrial scale by Eli Lilly & Co. in the same year. It is a deacetoxylated derivative of cephaloglycin that is not metabolized in vivo. When administered orally, it shows a much higher serum concentration and much lower tendency to induce diarrhea than cephaloglycin. Cephalexin has been used widely and is the most popular orally active antibiotic in the world for treatment of respiratory tract, urinary tract, surgical, ear and nose, and other infections caused by Staphylococcus, Streptococcus, Escherichia coli, Klebsiella, Enterobacter, and Proteus.

Chemical Properties

White to Off-White Solid

Originator

Ceporex,Glaxo,UK,1970

Uses

Cephalosporin antibacterial.

Uses

Semi-synthetic cephalosporin antibiotic.

Uses

A semisynthetic cephalorsporin antibiotic.

Definition

ChEBI: The hydrate of cephalexin.

Manufacturing Process

To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine (0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7- aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride salt was added, followed by triethylamine (12.1 ml) and dimethylformamide (140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2 hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To the resultant solution, hydrochloric acid (54 ml) was added followed by zinc (21.8 g) in portions over a period of 5 minutes, the temperature being maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and the solution stirred at 15°C to 20°C for 7 hours.
The pH was adjusted to 3.3 with triethylamine and semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200 ml) and the cephalexin recovered, yield 75%.

brand name

Keflex (Panixine (Ranbaxy).

Therapeutic Function

Antibiotic

CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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CEPHALEXIN MONOHYDRATE Suppliers

Americas 1 Canada 1 China 135 Europe 2 France 2 Germany 3 India 21 Italy 2 Japan 2 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 11 United States 26 Global 211
Tokyo Chemical Industry UK Ltd.
Tel
--
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Email
sales@tci-uk.co.uk
Country
United Kingdom
ProdList
1637
Advantage
50
Key Organics Limited/Bionet Research
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--
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Email
enquiries@keyorganics.ltd.uk
Country
United Kingdom
ProdList
6663
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50
Whyte Chemicals
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sales@whytechemicals.co.uk
Country
United Kingdom
ProdList
3748
Advantage
50
Leancare Ltd.
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enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
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42
CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
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United Kingdom
ProdList
6666
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UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
Country
United Kingdom
ProdList
6098
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47
Eurolabs Limited
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United Kingdom
ProdList
6309
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Apollo Scientific Ltd.
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sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
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MOLEKULA Ltd.
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kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
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Sequoia Research Products Ltd.
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sales@seqchem.com
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United Kingdom
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KEMPROTEC Limited
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enquiries@kemprotec.com
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United Kingdom
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View Lastest Price from CEPHALEXIN MONOHYDRATE manufacturers

Apeloa production Co.,Limited
Product
Cephalexin monohydrate 23325-78-2
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
112000
Release date
2024-06-03
Hebei Weibang Biotechnology Co., Ltd
Product
CEPHALEXIN MONOHYDRATE 23325-78-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2023-03-28
Hebei Mojin Biotechnology Co., Ltd
Product
CEPHALEXIN MONOHYDRATE 23325-78-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-11

23325-78-2, CEPHALEXIN MONOHYDRATERelated Search:

D-2-Phenylglycine 7-Amino-3-methyl-3-cephem-4-carboxylic acid L-Cephalexin 2,5-Piperazinedione, 3-(hydroxymethylene)-6-phenyl- Cephalexin Sulfoxide Cephalexin Diketopiperazine [6R-[6α,7β(R*)]]-7-[(AMinophenylacetyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0 Phenylglycylcefalexin [6R-[6α,7β(R*)]]-7-[(AMinophenylacetyl)aMino]-3-Methylene-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylic Acid SodiuM Salt (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2- 3-Hydroxy-4-Methyl-2(5H)-thiophenone CEPHALEXIN MONOHYDRATE MICRO/COMPACTED CEPHALEXIN MONOHYDRATE CEPHALEXIN-D5, HYDROCHLORIDE HYDRATE Cephalexin monohydrate,compacted Cephalexin monohydrate, powder CEPHALEXIN MONOHYDRATE--N/H (pivaloyloxy)methyl [6R-[6alpha,7beta(R*)]]-7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate monohydrochloride

  • CEPHALEXIN HYDRATE
  • CEPHALEXIN MONOHYDRATE
  • CEFALEXIN HYDRATE
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrate, (6R,7R)-
  • cefalexin monohydrat
  • CEPHALEXIN MONOHYDRATE BP USP GRADE
  • CEFALEXIN MONOHYDRATE
  • KEFLEX
  • Cephalexin monhydrochloride
  • Cephalexin (400 mg)
  • Cephalexin (400 mg)J0D296996ug/mg(an)
  • Cefalexin(coMpacted)
  • Cefalexine Monohydrate
  • [6R-[6alpha,7beta(R*)]]-7-(2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cephalexin Monohydrate USP
  • (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-me thyl-8-oxo-5-thia-1-azabi
  • Cephalexin Monohydrate (Discontinued See C256800)
  • CEPHALEXIN MONOHYDRATE USP/EP/BP
  • Cephalexin MonohydrateQ: What is Cephalexin Monohydrate Q: What is the CAS Number of Cephalexin Monohydrate Q: What is the storage condition of Cephalexin Monohydrate
  • Cephalexin (1099008)
  • CEPHALEXIN 1-HYDRATE
  • cephalexin monohydrfate
  • Cephalexin hydrate in 0.1 M HCl
  • 23325-78-2
  • C16H17N3O4SH2O
  • KEFLEX
  • Antibiotics for Research and Experimental Use
  • beta-Lactams (Antibiotics for Research and Experimental Use)
  • Biochemistry