CEPHALEXIN MONOHYDRATE
- Product Name
- CEPHALEXIN MONOHYDRATE
- CAS No.
- 23325-78-2
- Chemical Name
- CEPHALEXIN MONOHYDRATE
- Synonyms
- KEFLEX;CEFALEXIN HYDRATE;CEPHALEXIN HYDRATE;Cephalexin (400 mg);cefalexin monohydrat;Cefalexin(coMpacted);Cephalexin (1099008);CEPHALEXIN 1-HYDRATE;CEFALEXIN MONOHYDRATE;CEPHALEXIN MONOHYDRATE
- CBNumber
- CB4153386
- Molecular Formula
- C16H19N3O5S
- Formula Weight
- 365.4
- MOL File
- 23325-78-2.mol
CEPHALEXIN MONOHYDRATE Property
- Melting point:
- >161°C (dec.)
- refractive index
- 154 ° (C=0.5, H2O)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- NH4OH 1 M: 50 mg/mL, clear, yellow
- form
- solid
- color
- White to Light Beige
- Water Solubility
- 13.5g/L(25 ºC)
- Merck
- 14,1974
- BRN
- 965503
- Stability:
- Unstable in Solution
- InChIKey
- AVGYWQBCYZHHPN-KJTIIWGRSA-N
- CAS DataBase Reference
- 23325-78-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43
- Safety Statements
- 22-36/37-45-24/25
- WGK Germany
- 3
- RTECS
- XI0350000
- HS Code
- 29419052
- Toxicity
- LD50 in mice, rats (g/kg): 1.6-4.5, >5.0 orally; 0.4-1.3, >3.7 i.p. (Welles)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C0675000
- Product name
- Cephalexin monohydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- c0675000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 1099008
- Product name
- Cephalexin
- Packaging
- 400mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 257237
- Product name
- Cephalexin hydrate
- Packaging
- 100g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CS-2139
- Product name
- Cephalexin monohydrate
- Purity
- ≥98.0%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B1078
- Product name
- Cephalexin monohydrate
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
CEPHALEXIN MONOHYDRATE Chemical Properties,Usage,Production
Description
Cephalexin was first synthesized in 1967 by Glaxo Research Laboratories and first produced on an industrial scale by Eli Lilly & Co. in the same year. It is a deacetoxylated derivative of cephaloglycin that is not metabolized in vivo. When administered orally, it shows a much higher serum concentration and much lower tendency to induce diarrhea than cephaloglycin. Cephalexin has been used widely and is the most popular orally active antibiotic in the world for treatment of respiratory tract, urinary tract, surgical, ear and nose, and other infections caused by Staphylococcus, Streptococcus, Escherichia coli, Klebsiella, Enterobacter, and Proteus.
Chemical Properties
White to Off-White Solid
Originator
Ceporex,Glaxo,UK,1970
Uses
Cephalosporin antibacterial.
Uses
Semi-synthetic cephalosporin antibiotic.
Uses
A semisynthetic cephalorsporin antibiotic.
Definition
ChEBI: The hydrate of cephalexin.
Manufacturing Process
To a 1 liter flask containing dimethylformamide at 0°C, was added 24.8 g
sodium N-(2-methoxycarbonyl-1-methylvinyl)-D-α-phenylglycine (prepared
from sodium D-α-phenylglycine and methyl acetoacetate). The mixture was
cooled to -40°C and methyl chloroformate (7.5 ml) and dimethylbenzylamine
(0.26 ml) added. After stirring for 25 minutes, p-nitrobenzyl 7-
aminodesacetoxycephalosporanate (32.8 g) in the form of its hydrochloride
salt was added, followed by triethylamine (12.1 ml) and dimethylformamide
(140 ml) over a period of 20 minutes. The reaction mixture was stirred for 2
hours at -25°C to -35°C, then warmed to 0°C and water (32 ml) added. To
the resultant solution, hydrochloric acid (54 ml) was added followed by zinc
(21.8 g) in portions over a period of 5 minutes, the temperature being
maintained at 5°C to 10°C. Further hydrochloric acid (35 ml) was added and
the solution stirred at 15°C to 20°C for 7 hours.
The pH was adjusted to 3.3 with triethylamine and
semicarbazidehydrochloride (9.5 g) added. The mixture was brought back to
pH 3 with further triethylamine, then stirred for 30 minutes at pH 3. The
resultant mixture was adjusted slowly over 4 hours to pH 6.8 by addition of
triethylamine, seeding being carried out when pH 4.5 was reached. The precipitated cephalexin was filtered off, washed with dimethylformamide (200
ml) and the cephalexin recovered, yield 75%.
brand name
Keflex (Panixine (Ranbaxy).
Therapeutic Function
Antibiotic
CEPHALEXIN MONOHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CEPHALEXIN MONOHYDRATE manufacturers
- Product
- Cephalexin monohydrate 23325-78-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 112000
- Release date
- 2024-06-03
- Product
- CEPHALEXIN MONOHYDRATE 23325-78-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- CEPHALEXIN MONOHYDRATE 23325-78-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000tons
- Release date
- 2023-08-11