ChemicalBook > CAS DataBase List > 2-Fluorophenylboronic acid

2-Fluorophenylboronic acid

Product Name
2-Fluorophenylboronic acid
CAS No.
1993-03-9
Chemical Name
2-Fluorophenylboronic acid
Synonyms
2-Fluorophenylboronic;2-Flurorphenylboronic acid;2-FLUOROBENZENEBORONIC ACID;AKOS BRN-0104;2-fluoroborate;RARECHEM AH PB 0215;2-Fluorophenylboroni;o-Fluorphenylborsaeure;uorobenzeneboronic acid;Vonoprazan Impurity 215
CBNumber
CB4153982
Molecular Formula
C6H6BFO2
Formula Weight
139.92
MOL File
1993-03-9.mol
More
Less

2-Fluorophenylboronic acid Property

Melting point:
101-110 °C (lit.)
Boiling point:
267.8±42.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
8.32±0.58(Predicted)
form 
Crystalline Powder
color 
White to light yellow
BRN 
3030413
InChI
InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H
InChIKey
QCSLIRFWJPOENV-UHFFFAOYSA-N
SMILES
B(C1=CC=CC=C1F)(O)O
CAS DataBase Reference
1993-03-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-22
Safety Statements 
37/39-26-36/37/39-27-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29319090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
445223
Product name
2-Fluorophenylboronic acid
Purity
≥95%
Packaging
1g
Price
$68.8
Updated
2025/07/31
Sigma-Aldrich
Product number
445223
Product name
2-Fluorophenylboronic acid
Purity
≥95%
Packaging
10g
Price
$491.75
Updated
2025/07/31
TCI Chemical
Product number
F0407
Product name
2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
F0407
Product name
2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$72
Updated
2025/07/31
TCI Chemical
Product number
F0407
Product name
2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$213
Updated
2025/07/31
More
Less

2-Fluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

suzuki reaction

Uses

2-Fluorophenylboronic Acid, is used in Rh-catalyzed enantioselective addition reactions, and Rhodium and Palladium-catalyzed substitution reactions. It can also be used in the preparation of phenylboronic catechol esters as promising anion receptors for polymer electrolytes.

Uses

Used for the preparation of biologically active biphenyls and arylboron difluoride Lewis acids.

Synthesis

1072-85-1

1993-03-9

The general procedure for the synthesis of 2-fluorophenylboronic acid from o-bromofluorobenzene was as follows: 10.0 g (57.1 mmol) of 1-bromo-2-fluorobenzene and anhydrous tetrahydrofuran were added to a reaction flask and the mixture was subsequently cooled to -70 °C. At -70 °C, 44.2 ml (68.5 mmol) of 1.55 M n-butyllithium solution was slowly added dropwise to the reaction mixture. The temperature was maintained at -70 °C and stirring of the reaction mixture was continued for 1.5 hours. Subsequently, 21.5 g (114.2 mmol) of triisopropyl borate was added dropwise and the reaction temperature was gradually raised to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, aqueous hydrochloric acid was added to the reaction mixture and extracted with dichloromethane. The organic phases were combined and the solvent was removed by distillation under reduced pressure to give the crude product of 2-fluorophenylboronic acid. The crude product was purified by column chromatography (eluent: hexane/acetone) to give 4.8 g (yield: 61%) of pure 2-fluorophenylboronic acid.

References

[1] Patent: US2012/273770, 2012, A1. Location in patent: Page/Page column 24
[2] Patent: US2004/6076, 2004, A1. Location in patent: Page 15
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439

2-Fluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Trimethyl borate 1-Fluoro-2-iodobenzene

Preparation Products

More
Less

2-Fluorophenylboronic acid Suppliers

Americas 1 Belgium 2 China 297 Europe 3 France 2 Germany 13 India 14 Italy 1 Japan 3 Jordan 1 Russia 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 19 United States 58 Global 419
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Rare Earth Products Inc
Tel
--
Fax
--
Email
sales@rareearthproducts.com
Country
United States
ProdList
1095
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
AOBChem USA
Tel
--
Fax
--
Email
sales@aobchem.com
Country
United States
ProdList
3487
Advantage
50
Allweys LLC
Tel
--
Fax
--
Email
sales@allweysllc.com
Country
United States
ProdList
690
Advantage
30
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
RnD SciChem, LLC
Tel
--
Fax
--
Email
rndscichem@gmail.com
Country
United States
ProdList
569
Advantage
0
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Louston International
Tel
--
Fax
--
Email
sales@louston.com
Country
United States
ProdList
525
Advantage
58
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
HDH Pharma, Inc.
Tel
--
Fax
--
Email
catalog@hdhpharma.com
Country
United States
ProdList
6248
Advantage
62
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Neogen Chemicals Limited
Tel
--
Fax
--
Email
info@neogenchem.com
Country
United States
ProdList
286
Advantage
51
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
GL CHEMTEC INTERNATIONAL LIMITED
Tel
--
Fax
--
Email
products@glchemtec.ca
Country
United States
ProdList
216
Advantage
66
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Bio-Vin Research Laboratories
Tel
--
Fax
--
Email
sales@biovinresearch.com
Country
United States
ProdList
6210
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
Synthonix
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
1423
Advantage
68
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Chemiplus Corporation
Tel
--
Fax
--
Email
okazaki@chemiplus.com
Country
United States
ProdList
3198
Advantage
38
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Syntech Labs
Tel
--
Fax
--
Email
info@syntechlabs.com
Country
United States
ProdList
730
Advantage
43
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
1218
Advantage
30
Optimachem
Tel
--
Fax
--
Email
dmills@optimachem.com
Country
United States
ProdList
255
Advantage
66
Atlantic SciTech Group, Inc.
Tel
--
Fax
--
Email
sales@astginc.com
Country
United States
ProdList
2308
Advantage
43
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
Asymchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@asymchem.com
Country
United States
ProdList
1315
Advantage
69
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Digital Specialty Chemicals, Inc.
Tel
--
Fax
--
Email
sales@digitalchem.com
Country
United States
ProdList
710
Advantage
85
More
Less

View Lastest Price from 2-Fluorophenylboronic acid manufacturers

Hebei Jingbo New Material Technology Co., Ltd
Product
2-Fluorophenylboronic acid 1993-03-9
Price
US $5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200000
Release date
2023-12-27
Henan Fengda Chemical Co., Ltd
Product
2-Fluorophenylboronic acid 1993-03-9
Price
US $30.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-26
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Product
2-Fluorophenylboronic acid 1993-03-9
Price
US $30.00-150.00/Kg
Min. Order
100Kg
Purity
99.0% up
Supply Ability
50 tons per month
Release date
2022-10-07

1993-03-9, 2-Fluorophenylboronic acidRelated Search:

2-Fluoropyridine-4-boronic acid Phenylboronic acid Sodium tetrafluoroborate Ammonium fluoborate Florfenicol Transfluthrin 4-Fluorobenzaldehyde Zinc borate Fluoroboric acid Potassium tetrafluoroborate 1,2-Difluorobenzene Citric acid Ascoric Acid 3,5-Difluorophenylboronic acid Phenylacetone FENFLURAMINE 4-Fluorophenylboronic acid292,4-Fluorophenylboronic Acid (contains varying amounts of Anhydride) 2-ETHOXYPHENYLBORONIC ACID

  • 2-Fluorophenylboronic acid, May contain varying amounts of anhydride, 97%
  • 2-Fluorophenylboroni
  • 2-Fluorophenylboronic acid, 98% 1GR
  • Boronic acid, B-(2-fluorophenyl)-
  • BORONIC ACID, B-(2-FLUOROPHENYL)-; O-FLUORPHENYLBORSAEURE;
  • o-Fluorphenylborsaeure
  • o-fluoro-benzeneboronic acid
  • 2-Flurorphenylboronic acid
  • 2-Fluorobenzeneboronic Acid (Contains Varying Amounts Of Anhydride)
  • 2-Fluorophenylboronic
  • 2-Fluorobenzeneboronic acid 97%
  • 2-Fluorobenzeneboronicacid97%
  • 2-FLUOROBENZENEBORONIC ACID
  • 2-FLUOROPHENYLBORONIC ACID
  • AKOS BRN-0104
  • O-FLUOROPHENYLBORONIC ACID
  • RARECHEM AH PB 0215
  • ORTHOFLUOROPHENYLBORONIC ACID
  • 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
  • 2-Fluorophenylboronic acid ,98%
  • 2-fluoroborate
  • uorobenzeneboronic acid
  • 2-Fluorophenylboronic Acid extrapure, 97%
  • Vonoprazan Impurity 215
  • (2-Fluorophenyl)boronic acid - [F3340]
  • 1993-03-9
  • 199-33-9
  • 1993-03-09
  • 1993-03-4
  • 1993/3/9
  • 34-03-9
  • 1993-09-3
  • 93-03-9
  • 3/9/1993
  • 9/3/1993
  • 1993-3-9
  • 1933-03-9
  • C6H6BFO2
  • C6H6O2BF
  • FC6H4BOH2
  • Aryl
  • Boronic Acids and Derivatives
  • Organometallic Reagents
  • Boronic Acids
  • B (Classes of Boron Compounds)
  • Boronate Ester
  • Potassium Trifluoroborate
  • B (Classes of Boron Compounds)
  • Boronic Acids
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Substituted Boronic Acids
  • blocks
  • BoronicAcids
  • FluoroCompounds
  • Boronic Acid
  • Aryl
  • Fluorinated