ChemicalBook > CAS DataBase List > 5-Fluoro-3-methylindole

5-Fluoro-3-methylindole

Product Name
5-Fluoro-3-methylindole
CAS No.
392-13-2
Chemical Name
5-Fluoro-3-methylindole
Synonyms
5-Fluoro-3-methyl-1H-indole;5-FLUORO-3-METHYLINDOLE;1H-5-Fluoro-3-methyindole;1H-5-FLUORO-3-METHYLINDOLE;1H-Indole, 5-fluoro-3-methyl-
CBNumber
CB4170831
Molecular Formula
C9H8FN
Formula Weight
149.16
MOL File
392-13-2.mol
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5-Fluoro-3-methylindole Property

Melting point:
83.0 to 87.0 °C
Boiling point:
269.2±20.0 °C(Predicted)
Density 
1.219±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
16.46±0.30(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C9H8FN/c1-6-5-11-9-3-2-7(10)4-8(6)9/h2-5,11H,1H3
InChIKey
CSDHAGJNOQIBHZ-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(F)C=C2)C(C)=C1
CAS DataBase Reference
392-13-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
36/37/39-45
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1053
Product name
5-Fluoro-3-methylindole
Purity
>98.0%(GC)
Packaging
200mg
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
F1053
Product name
5-Fluoro-3-methylindole
Purity
>98.0%(GC)
Packaging
1g
Price
$185
Updated
2025/07/31
TRC
Product number
F597990
Product name
5-Fluoro-3-methylindole
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
F597990
Product name
5-Fluoro-3-methylindole
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
F597990
Product name
5-Fluoro-3-methylindole
Packaging
500mg
Price
$200
Updated
2021/12/16
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5-Fluoro-3-methylindole Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

5-Fluoro-3-methylindole is used to study its ionization potential and the origin of nonexponential tryptophan fluorescnece decay in proteins.

Synthesis

2338-71-8

392-13-2

5-Fluoro-1H-indole-3-carboxaldehyde (3.2 g, 19.6 mmol) was used as raw material and dissolved in 10 mL of anhydrous tetrahydrofuran. Subsequently, lithium aluminum hydride (2.61 g, 68.6 mmol) was added to this solution. The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with 18 mL of 20% sodium hydroxide aqueous solution. The mixture was extracted by adding 60 mL of dichloromethane to the mixture and the organic layer was washed with 40 mL of saturated aqueous sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with petroleum ether/ethyl acetate (V/V=50/1) as eluent to afford 5-fluoro-3-methylindole as a light yellow solid (2.41 g, 82.3% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 150.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ: 7.30-7.23 (m, 2H), 7.04 (s, 1H), 6.97 (td, J=9.0,2.0 Hz, 1H), 2.33 (s, 3H).

References

[1] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00362
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3250 - 3254
[3] Angew. Chem., 2013, vol. 125, # 11, p. 3332 - 3336,5
[4] Organic Letters, 2015, vol. 17, # 11, p. 2652 - 2655

5-Fluoro-3-methylindole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-3-methylindole Suppliers

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View Lastest Price from 5-Fluoro-3-methylindole manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Fluoro-3-methylindole 392-13-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
5-Fluoro-3-Methylindole 392-13-2
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
5-Fluoro-3-methyl-1H-indole 392-13-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-15

392-13-2, 5-Fluoro-3-methylindoleRelated Search:

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  • 1H-5-FLUORO-3-METHYLINDOLE
  • 5-Fluoro-3-methyl-1H-indole
  • 1H-5-Fluoro-3-methyindole
  • 1H-Indole, 5-fluoro-3-methyl-
  • 5-FLUORO-3-METHYLINDOLE
  • 392-13-2
  • C9H8FN
  • Indole/indoline/oxindole
  • Indole and Indoline
  • Indole