ChemicalBook > CAS DataBase List > Boc-Lys(Boc)-OH

Boc-Lys(Boc)-OH

Product Name
Boc-Lys(Boc)-OH
CAS No.
2483-46-7
Chemical Name
Boc-Lys(Boc)-OH
Synonyms
NSC 164052;BOC-LYS(BOC);BOC-L-LYS(BOC);BOC-LYS(BOC)-OH;Boc-Lys（Boc)-0H;BOC-L-LYSINE(BOC);Boc-L-Lys(Boc)-OH;Na, Ne-Diboc-L-lysine;Nα,ε-Bis-Boc-L-lysine;Boc-Lys(Boc)-OH, 95 %
CBNumber
CB4172901
Molecular Formula
C16H30N2O6
Formula Weight
346.42
MOL File
2483-46-7.mol
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Boc-Lys(Boc)-OH Property

Boiling point:
514.4±45.0 °C(Predicted)
Density 
1.109±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in chloroform, ether, ethyl acetate and methanol
pka
3.99±0.21(Predicted)
form 
Low Melting Solid
color 
White
optical activity
-3.22°(C=5.00, MEOH)
InChI
InChI=1S/C16H30N2O6/c1-15(2,3)23-13(21)17-10-8-7-9-11(12(19)20)18-14(22)24-16(4,5)6/h11H,7-10H2,1-6H3,(H,17,21)(H,18,22)(H,19,20)/t11-/m0/s1
InChIKey
FBVSXKMMQOZUNU-NSHDSACASA-N
SMILES
C(O)(=O)[C@H](CCCCNC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference
2483-46-7(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003904
Product name
Boc-Lys(Boc)-OH
Purity
AldrichCPR
Packaging
250MG
Price
$66.1
Updated
2025/07/31
Usbiological
Product number
275680
Product name
N-alpha,epsilon-Bis-Boc-L-lysine
Packaging
50g
Price
$347
Updated
2021/12/16
TRC
Product number
B656995
Product name
Nα,Nε-Bis-boc-L-lysine
Packaging
250mg
Price
$40
Updated
2021/12/16
TRC
Product number
B656995
Product name
Nα,Nε-Bis-boc-L-lysine
Packaging
1g
Price
$55
Updated
2021/12/16
Usbiological
Product number
B2526-73
Product name
Na, Ne-bis-Boc-L-lysine
Packaging
5g
Price
$403
Updated
2021/12/16
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Boc-Lys(Boc)-OH Chemical Properties,Usage,Production

Chemical Properties

Clear Oil

Uses

Nalpha, Nepsilon-Di-Boc-L-lysine is used as fine chemical intermediate, synthesis intermediates.

Definition

ChEBI: N2,N6-Bis{[(2-methyl-2-propanyl)oxy]carbonyl}lysine is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Synthesis

24424-99-5

657-27-2

2483-46-7

The general procedure for the synthesis of (S)-2,6-di-Boc-aminohexanoic acid from di-tert-butyl dicarbonate and L-lysine hydrochloride was as follows: first, L-lysine hydrochloride was dissolved in 50 mL of a solvent mixture of 1,4-dioxane and water (1:1, v/v), and the pH was adjusted to 10-11 by the dropwise addition of 1 M NaOH solution Next, the pH of L-lysine hydrochloride (2.0 g) was adjusted to 10-11 by slow addition through the addition funnel. Di-tert-butyl dicarbonate (6.0 g) dissolved in 20 mL of dioxane. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and subsequently acidified with 4 M KHSO4 solution to pH=1-2. The acidified solution was extracted twice with ethyl acetate, the organic phases were combined and dried under reduced pressure to give a colorless liquid product in 100% yield.

References

[1] Patent: US2014/127138, 2014, A1. Location in patent: Paragraph 0321; 0322
[2] Patent: US2016/376618, 2016, A1. Location in patent: Paragraph 0206-0212
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1428 - 1436
[4] Patent: WO2014/97178, 2014, A1. Location in patent: Page/Page column 49
[5] New Journal of Chemistry, 2018, vol. 42, # 5, p. 3192 - 3195

Boc-Lys(Boc)-OH Preparation Products And Raw materials

Raw materials

Hexane Di-tert-butyl dicarbonate L-Lysine L-Lysine hydrochloride 1,4-Dioxane Ethyl acetate Sodium hydroxide Potassium bisulfate

Preparation Products

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View Lastest Price from Boc-Lys(Boc)-OH manufacturers

Hefei TNJ Chemical Industry Co.,Ltd.
Product
Boc-Lys(Boc)-OH 2483-46-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99.8
Supply Ability
20000
Release date
2025-08-01
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Lys(Boc)-OH 2483-46-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-16
Career Henan Chemical Co
Product
(S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid 2483-46-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-15

2483-46-7, Boc-Lys(Boc)-OHRelated Search:

N-Boc-N'-Cbz-L-lysine N-Boc-L-Phenylalaninol BOC-PYR-OET BOC-L-LEUCINOL Boc-Lys-OH 1,1'-Carbonyldiimidazole 6-Aminocaproic acid Carbonyl iron powder BOC-LYS(BOC)-OH DCHA N,N'-Di-Boc-L-lysine hydroxysuccinimide ester BOC-LYS(BOC)-ONP Na, Ne-bis-Boc-L-2-aminoadipamic Acid tert-Butyl Ester NA, NE-BIS-BOC-L-LYSINE TERT-BUTYL ESTER Boc-Lys(Boc)-OH L-LYSINE, N2,N6-BIS[(1,1-DIMETHYLETHOXY)CARBONYL]-N6-METHYL- (S)-N-ALPHA-N'-DI-T-BUTYLOXYCARBONYL-4-PIPERIDYLALANINE BOC-CIS-1,3-AMINO-1-CYCLOHEXANE CARBOXYLIC ACID

  • N-ALPHA,EPSILON-BIS-BOC-L-LYSINE
  • N-ALPHA,N-EPSILON-DI-T-BUTOXYCARBONYL-L-LYSINE
  • BOC-L-LYSINE(BOC)
  • BOC-L-LYS(BOC)
  • BOC-LYS(BOC)
  • BOC-LYS(BOC)-OH
  • NA, NE-BIS-BOC-L-LYSINE
  • (S)-2,6-BIS-TERT-BUTOXYCARBONYLAMINO-HEXANOIC ACID
  • Na, Ne-Diboc-L-lysine
  • N2,N6-Bis-(tert-butoxycarbonyl)-L-lysine
  • N2,N6-Bis(tert-butoxycarbonyl)lysine
  • N2,N6-Bis(tert-butyloxycarbonyl)-L-lysine
  • N2,N6-Bis[(1,1-dimethylethoxy)carbonyl]-L-lysine
  • Nα,Nε-Bis(tert-butoxycarbonyl)-L-lysine
  • N-tert-Butoxycarbonyl-Nε-Boc-L-lysine
  • 2-amino-7-[(2-methylpropan-2-yl)oxy]-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-7-oxoheptanoic acid
  • Nα,Nε-Bis-Boc-L-Lys-OH
  • N-beta,epsilon-bis-Boc-L-lysine
  • Di[N-(tert-butoxycarbonyl)]-L-lysine
  • NSC 164052
  • L-Lysine-d4-bis-N-t-BOC
  • N2,N6-Bis-Boc-L-lysine
  • Nα, Nε-Bis-boc-L-lysine
  • N2,N6-Bis-(tert-butoxycarbonyl)-L-lysine ,99%
  • N<sup>2</sup>,N<sup>6</sup>-Bis-(tert-butoxycarbonyl)-L-lysine
  • Boc-L-Lys(Boc)-OH
  • Nα,ε-Bis-Boc-L-lysine≥ 98% (HPLC)
  • Nalpha,Nepsilon-Di-Boc-L-lysine
  • (Tert-Butoxy)Carbonyl Lys(Boc)-OH(Syrup)
  • L-Lysine,N2,N6-bis[(1,1-dimethylethoxy)carbonyl]-
  • (2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoicaci
  • (S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid USP/EP/BP
  • Nα,ε-Bis-Boc-L-lysine
  • 6-Bis-tert-butoxycarbonylaminohexanoic acid
  • (2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
  • TIANFUCHEM--2483-46-7---(S)-2,6-Bis-tert-butoxycarbonylaminohexanoic acid
  • Di-tert-butoxycarbonyl-L-lysine
  • Boc-Lys(Boc)-OH, 95 %
  • Lysine Impurity 15 (Di-Boc-L-lysine)
  • Boc-Lys（Boc)-0H
  • Nalpha,Nepsilon-Di-Boc-L-lysine 98%
  • NAlpha, NEpsilon-Bis-boc-L-lysine
  • 2483-46-7
  • C16H30N2O6
  • Amino Acid Derivatives
  • Lysine [Lys, K]
  • Boc-Amino Acids and Derivative
  • Amino Acids 13C, 2H, 15N
  • Boc-Amino acid series
  • Amino Acids & Derivatives