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1-HYDROXYPIPERIDINE

Product Name
1-HYDROXYPIPERIDINE
CAS No.
4801-58-5
Chemical Name
1-HYDROXYPIPERIDINE
Synonyms
1-piperidinol;piperidin-1-ol;Hydroxypiperidine;1-HYDROXYPIPERDINE;1-hydroxy-piperidin;N-HYDROXYPIPERIDINE;1-HYDROXYPIPERIDINE;Piperidine, 1-hydroxy-;Bupivacaine Impurity 27;1-HYDROXYPIPERIDINE 96+%
CBNumber
CB4185440
Molecular Formula
C5H11NO
Formula Weight
101.15
MOL File
4801-58-5.mol
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1-HYDROXYPIPERIDINE Property

Melting point:
37-39 °C
Boiling point:
146-148℃ (1 Torr)
Density 
0.9903 (rough estimate)
refractive index 
1.4550 (estimate)
Flash point:
78 °C
storage temp. 
2-8°C
pka
14.19±0.20(Predicted)
form 
low melting solid
color 
White
BRN 
102726
InChIKey
LKPFBGKZCCBZDK-UHFFFAOYSA-N
EPA Substance Registry System
Piperidine, 1-hydroxy- (4801-58-5)
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Safety

WGK Germany 
3
RTECS 
TN6829550
F 
3-10
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
56207
Product name
1-Hydroxypiperidine
Purity
≥96.0% (GC)
Packaging
1g
Price
$146
Updated
2025/07/31
Apolloscientific
Product number
OR961933
Product name
1-Hydroxypiperidine
Purity
95%
Packaging
1g
Price
$140
Updated
2021/12/16
Apolloscientific
Product number
OR961933
Product name
1-Hydroxypiperidine
Purity
95%
Packaging
5g
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006758
Product name
1-HYDROXYPIPERIDINE
Purity
95.00%
Packaging
1G
Price
$674.05
Updated
2021/12/16
Alichem
Product number
4801585
Product name
Piperidin-1-ol
Packaging
5g
Price
$683
Updated
2021/12/16
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1-HYDROXYPIPERIDINE Chemical Properties,Usage,Production

Chemical Properties

Soluble in water, organic solvents, aqueous acids, and bases.

Uses

Base for Fmoc-based solid phase peptide synthesis

Light stabilizing agent

Uses

Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012

Synthesis

110-89-4

4801-58-5

General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine.

References

[1] Synlett, 2017, vol. 28, # 17, p. 2315 - 2319
[2] Tetrahedron Letters, 2001, vol. 42, # 20, p. 3419 - 3422
[3] Justus Liebigs Annalen der Chemie, 1948, vol. 559, p. 1,22, 23
[4] Chemische Berichte, 1951, vol. 84, p. 690,698
[5] Chemische Berichte, 1892, vol. 25, p. 2782

1-HYDROXYPIPERIDINE Preparation Products And Raw materials

Raw materials

1-Ethylpiperidine

Preparation Products

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1-HYDROXYPIPERIDINE Suppliers

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View Lastest Price from 1-HYDROXYPIPERIDINE manufacturers

Career Henan Chemical Co
Product
1-HYDROXYPIPERIDINE 4801-58-5
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

4801-58-5, 1-HYDROXYPIPERIDINERelated Search:

4-BENZOYLOXY-TEMPO 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy 4-Amino-TEMPO, free radical 4-ACETAMIDO-TEMPO 1-HYDROXYPIPERIDINE 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl 4-Oxo-2,2,6,6-tetramethylpiperidinooxy 2,2,6,6-Tetramethylpiperidinooxy SCOPOLAMINE N-OXIDE HYDROBROMIDE 5-(4-Hydroxypiperidino)-2-thiophenecarbaldehyde Light Stabilizer UV-622 DL-Pipecolinic acid 4-(4-Chlorophenyl)-4-hydroxypiperidine, crystalline, 99+% N-BOC-4-Hydroxypiperidine (R)-4-HYDROXY-PIPERIDIN-2-ONE Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate 4-[4-Chloro-3-(trifluoro methyl)phenyl]-4-hydroxypiperidine 4-HYDROXY-4-PHENYLPIPERIDINE

  • 1-HYDROXYPIPERIDINE
  • N-HYDROXYPIPERIDINE
  • 1-hydroxy-piperidin
  • 1-piperidinol
  • piperidin-1-ol
  • 1-HYDROXYPIPERIDINE 96+%
  • 1-HYDROXYPIPERDINE
  • Hydroxypiperidine
  • 1-Piperidinol/1-hydroxypiperidine
  • Piperidine, 1-hydroxy-
  • Bupivacaine Impurity 27
  • 1-Hydroxypiperidine >=96.0% (GC)
  • 4801-58-5
  • Piperidines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • C5 to C7
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Piperidines