elsilimomab

Product Name: elsilimomab
CAS No.: 468715-71-1
Chemical Name: elsilimomab
Synonyms: B-E8;elsilimomab;Research Grade Elsilimomab;Immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 kappa-chain, dimer
CBNumber: CB41856042
Formula Weight: 0
MOL File: Mol file

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elsilimomab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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elsilimomab Chemical Properties,Usage,Production

Uses

Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA)[1][2][3].

IC 50

IL-6: 1.4 nM (IC₅₀)

References

[1] Lee JJ, et al. A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol Ther. 2014 Jul;22(7):1254-1265. DOI:10.1038/mt.2014.59
[2] Burger R, et al. Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth. Haematologica. 2017 Feb;102(2):381-390. DOI:10.3324/haematol.2016.145060
[3] Finch DK, et al. Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol. 2011 Aug 26;411(4):791-807. DOI:10.1016/j.jmb.2011.06.031

elsilimomab Preparation Products And Raw materials

Raw materials

Preparation Products

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elsilimomab Suppliers

China 16 United States 1 Global 17

Wuhan Chemstan Biotechnology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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TargetMol Chemicals Inc.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Changsha Fuzhen Biotechnology Co.，LTD

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Olix (Shanghai) Pharmaceutical Technology Co., Ltd

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Atagenix Laboratories

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468715-71-1, elsilimomabRelated Search:

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elsilimomab

B-E8

Immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 kappa-chain, dimer

Research Grade Elsilimomab

468715-71-1