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6-bromoisoquinolin-3-amine

Product Name
6-bromoisoquinolin-3-amine
CAS No.
891785-28-7
Chemical Name
6-bromoisoquinolin-3-amine
Synonyms
6-bromoisoquinolin-3-amine;6-broMo-3-isoquinolinaMine;3-Isoquinolinamine,6-bromo-;3-Amino-6-bromoisoquinoline;3-Amino-6-bromoisoquinoline 97%;6-bromoisoquinolin-3-amine - [B5436];6-bromoisoquinolin-3-amine ISO 9001：2015 REACH;6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene
CBNumber
CB41856163
Molecular Formula
C9H7BrN2
Formula Weight
223.07
MOL File
891785-28-7.mol
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6-bromoisoquinolin-3-amine Property

Boiling point:
387.6±22.0 °C(Predicted)
Density 
1.649±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
4.49±0.38(Predicted)
form 
solid
color 
Light yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B292405
Product name
6-Bromoisoquinolin-3-amine
Packaging
250mg
Price
$550
Updated
2021/12/16
Matrix Scientific
Product number
139077
Product name
6-Bromoisoquinolin-3-amine
Purity
95%+
Packaging
5g
Price
$616
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB29230
Product name
6-Bromo-3-isoquinolinamine
Packaging
5G
Price
$650
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-9-X6
Product name
3-Amino-6-bromoisoquinoline
Purity
97%
Packaging
5G
Price
$668
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044798
Product name
6-BROMOISOQUINOLIN-3-AMINE
Purity
95.00%
Packaging
250MG
Price
$817.62
Updated
2021/12/16
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6-bromoisoquinolin-3-amine Chemical Properties,Usage,Production

Uses

6-Bromoisoquinolin-3-amine is employed in the comprehensive structure-activity relationship studies to identify the allosteric inhibitors that exhibit selective recognition of protein arginine methyltransferase PRMT3 in human cells.

Synthesis

925672-85-1

891785-28-7

General procedure for the synthesis of 6-bromoisoquinolin-3-amine from 1,6-dibromoisoquinolin-3-amine: 1,6-dibromoisoquinolin-3-amine (13.5 g, 45 mmol), ammonium formate (10.8 g, 172 mmol), and tetrakis(triphenylphosphine)palladium(0) (3.45 g, 3.0 mmol) were dissolved in 50 mL of DMF and the mixture was transferred to a 350 mL screw cap flask, sealed and heated at 50 °C for 48 hours. Subsequently, tetrakis(triphenylphosphine)palladium(0) (950 mg) and ammonium formate (3.0 g) were added supplementally to the reaction mixture and heating was continued at 50 °C for 48 hours. After completion of the reaction, the mixture was cooled to room temperature, the solid was collected by filtration, washed with a small amount of DMF and then with ether, and finally dried under vacuum at 50 °C to give the yellow amorphous solid product 6-bromoisoquinolin-3-amine (10.4 g, 90% yield). The product was detected by LCMS (API-ES), m/z: 222.9, 224.9 [M + 1]. 1H NMR (300MHz, DMSO-d6) δppm 8.81 (s, 1H), 7.80 (d, J = 1.6Hz, 1H), 7.73 (d, J = 8.8Hz, 1H), 7.22 (dd, J = 8.6, 1.9 Hz, 1H), 6.55 (s, 1H), 6.12 (s, 2H).

References

[1] Patent: WO2009/11871, 2009, A2. Location in patent: Page/Page column 188; 189
[2] Patent: WO2009/11880, 2009, A2. Location in patent: Page/Page column 159-160

6-bromoisoquinolin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-bromoisoquinolin-3-amine Suppliers

China 113 India 2 Ukraine 1 United Kingdom 2 United States 11 Global 129
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 6-bromoisoquinolin-3-amine manufacturers

Shanghai UCHEM Inc.
Product
3-Amino-6-bromoisoquinoline 891785-28-7
Price
US $244.00-667.00/g
Min. Order
5g
Purity
0.97
Supply Ability
25kg
Release date
2023-12-27
Career Henan Chemical Co
Product
6-bromoisoquinolin-3-amine 891785-28-7
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23
Career Henan Chemical Co
Product
6-bromoisoquinolin-3-amine 891785-28-7
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

891785-28-7, 6-bromoisoquinolin-3-amineRelated Search:

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