4-Methylbenzamide oxime Property

Melting point:

140-145 °C (lit.)

Boiling point:

258.1±33.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml

form 

A crystalline solid

pka

6.95±0.69(Predicted)

CAS DataBase Reference

19227-13-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

XS4870000

HazardClass 

IRRITANT

HS Code 

2928009090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Methylbenzamide oxime Chemical Properties,Usage,Production

Description

4-Methylbenzamide oxime is intended to be used as a building block in drug discovery chemistry.

Uses

N-Hydroxy-4-methyl-benzenecarboximidamide is a reactant used in the preparation of naphthyridine-based polycyclic hetarenes from N-hydroxybenzamidines and alkynes.

General Description

4-Methylbenzamide oxime is a benzonitrile derivative that can be prepared from 4-methylbenzonitrile and hydroxylamine hydrochloride. Its crystalline structure shows the presence of both intramolecular and intermolecular hydrogen bonds. 3-Aryl-5-trinitromethyl-1,2,4-oxadiazoles undergoes hydrolysis under acidic conditions to form 4-methylbenzamide oxime as one of the product.