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CONVALLATOXIN

Product Name
CONVALLATOXIN
CAS No.
508-75-8
Chemical Name
CONVALLATOXIN
Synonyms
Convapur;orglycon;CORGLYKON;Convalpur;corglycon;korglykon;NSC 407808;corglycone;Convallopan;convallaton
CBNumber
CB4190741
Molecular Formula
C29H42O10
Formula Weight
550.64
MOL File
508-75-8.mol
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CONVALLATOXIN Property

Melting point:
238-239℃ (water )
alpha 
D22 -1.7 ± 3° (c = 0.65 in methanol); D25 -9.4 ± 3° (c = 0.72 in dioxane)
Boiling point:
542°C (rough estimate)
Density 
1.41±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5376 (estimate)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
13.04±0.70(Predicted)
form 
Solid
color 
White to Off-White
Merck 
13,2538
Stability:
Hygroscopic
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Safety

RIDADR 
3249
WGK Germany 
2
RTECS 
GL4025000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
508-75-8(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (Frster)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C9140
Product name
Convallatoxin
Purity
≥65%
Packaging
100mg
Price
$159
Updated
2024/03/01
TRC
Product number
C685075
Product name
Convallatoxin
Packaging
1mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC137904
Product name
Convallatoxin
Packaging
1mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC137904
Product name
Convallatoxin
Packaging
2mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC137904
Product name
Convallatoxin
Packaging
5mg
Price
$255
Updated
2021/12/16
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CONVALLATOXIN Chemical Properties,Usage,Production

Originator

Convallatoxin,C-Strong Co., Ltd.

Uses

Convallatoxin is a cardenolide that is used in the treatment of congestive heart failure. It may also be used in the treatment of tumor cells at nanomolar concentrations due to its anti-proliferative effects

Definition

ChEBI: A cardenolide glycoside that consists of strophanthidin having a 6-deoxy-alpha-L-mannopyranosyl (L-rhamnosyl) group attached at position 3.

Manufacturing Process

1 part of grinded flowers Convallaria majalis and 12 parts of water was stirred for 15 hours at ambient temperature. After a filtration and washing with water, a clear brown filtrate was mixed with a concentrate solution of lead acetate. A lead consisted precipitate was filtered off and sodium phosphate was added to filtrate for removing the remaining lead. The solution was filtered again and 0.5 - 0.6 parts of a coal was added and the mixture was stirred for 3 hours at ambient temperature. The coal was filtered off, washed with a little water and dried at 30°-40°C. A hot CHCl3 was added to dry coal adsorbent. CHCl3 was distilled off to dryness in vacuum. The residue was dissolved in a little methanol and the obtained solution was shook 3 times with 2 volumes of petrol ether and then distilled to dryness in vacuum. This product was dissolved in minimum absolute ethanol and added to 10 volumes of dry ether. The formed precipitate was filtered and washed with ether to
give the glycoside as a gray powder. It was crystallized from diluted ethanol as colorless needles.

Therapeutic Function

Cardiotonic

Purification Methods

Crystallise convallatoxin from EtOAc, CHCl3/EtOH (9:1) or MeOH/Et2O. The tetraacetate has m 238-242o (from MeOH/Et2O), [] D 25 -5o (CHCl3). [Reyle et al. Helv Chim Acta 33 1541 1950, Fieser & Jacobson J Am Chem Soc 59 2335 1937 Beilstein 1 8 III/IV 3142.]

CONVALLATOXIN Preparation Products And Raw materials

Raw materials

Phenethyl alcohol

Preparation Products

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View Lastest Price from CONVALLATOXIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
CONVALLATOXIN 508-75-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-25
Dideu Industries Group Limited
Product
CONVALLATOXIN 508-75-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-09

508-75-8, CONVALLATOXINRelated Search:

Terrestrosin D Poricoic acid A(F) roburic acid Pachymic acid dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate ALLEOSIDE A Madecassic acid Madecassoside Carboxyatractyloside tracheloside Quinine Isosorbide dinitrate STROPHANTHIDIN TERPIN MONOHYDRATE CONVALLATOXIN periplogenin TRANS-TERPIN K-strophanthin-beta

  • STROPHANTHIN 3ALPHA-1-RHAMNOSIDE
  • STROPHANTHIDIN ALPHA-L-RHAMNOPYRANOSIDE
  • STROPHANTHIDIN A-L-RHAMNOPYRANOSIDE
  • CORGLYKON
  • CONVALLATOXIN
  • 20(22),5BETA-CARDENOLID-19-AL-3BETA,5BETA,14BETA-TRIOL-3BETA-D-[A-1-RHAMNOPYRANOSIDE]
  • Convallatoxine
  • Strophanthidin α-L-rhamnopyranoside, 3β,5α,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide 3-(6-deoxy-α-L-mannopyranoside)
  • 3β-(α-L-Rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14β-carda-20(22)-enolide
  • 3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide
  • 3β5α14-Trihydroxy-19-oxo-5β20(22)-cardenolide 3-(6-deoxy-α-L-mannopyranoside)
  • Strophanthidin α-L-rhamnopyranoside
  • CONVALLATOXIN(P)
  • Convallopan
  • Convapur
  • NSC 407808
  • orglycon
  • 5BETA,20[22]-CARDENOLIDE-19-ONE-3BETA,5ALPHA,14-TRIOL-3-[6-DEOXY-ALPHA-L-MANNOPYRANOSYL]
  • 3BETA,5ALPHA,14-TRIHYDROXY-19-OXO-5BETA,20[22]-CARDENOLIDE-3-[6-DEOXY-ALPHA-L-MANNOPYRANOSYL]
  • (3beta,5beta)-oxo
  • 0(22)-enolide
  • 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-5,14-dihydroxy-19-card-20(22)-enolid
  • 3beta-[(6-deoxy-alpha-l-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-5beta-card-2
  • 6-deoxy-strophanthidin-alpha-l-mannopyranosid
  • convallaotoxin
  • convallaton
  • convallatoxoside
  • convallotoxin
  • Convalpur
  • corglycon
  • corglycone
  • korglykon
  • strophanthidin,3-(6-deoxy-alpha-l-mannopyranoside)
  • strophanthidin-3,alpha-l-rhamnosid
  • strophanthidinalpha-l-rhamnoside
  • Convallatoxin (=Corglycon)
  • CONVALLATOXIN(RG)
  • (5S,10S,13R,14S)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(3,4,5-trihydroxy-6-methyl-2-oxanyl)oxy]-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carboxaldehyde
  • Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3β,5β)-
  • CONVALLATOXIN USP/EP/BP
  • psoriasis,Nuclear factor-κB,P-gp,Inhibitor,anti-proliferative,colitic,anti-inflammatory,Nuclear factor-kappaB,P-glycoprotein,Peroxisome proliferator-activated receptors,CD243,inhibit,Multidrug resistance protein 1,PPAR,NF-κB,MDR1,Convallatoxin,Pgp,ABCB1,Cluster of differentiation 243,inflammation,substrate
  • 508-75-8
  • C29H42O10
  • C21H34N6O7S
  • Aldehydes
  • Building Blocks
  • C13-C60
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks