6-Bromoindazole
- Product Name
- 6-Bromoindazole
- CAS No.
- 79762-54-2
- Chemical Name
- 6-Bromoindazole
- Synonyms
- 6-BROMO-1H-INDAZOLE;6-BROMOINDAZOLE;6-bromocarbazole;6-Bromoindazole >IFLAB-BB F2108-0126;1H-Indazole, 6-bromo-;6-Bromo-1H-indazole 95%;6-Bromo-1H-indazole, 95%;6-Bromo-1H-indazole;9-(trifluromethyl)acetanilide
- CBNumber
- CB4192785
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 79762-54-2.mol
6-Bromoindazole Property
- Melting point:
- 180-182
- Boiling point:
- 333.8±15.0 °C(Predicted)
- Density
- 1.770±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 12.78±0.40(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C7H5BrN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)
- InChIKey
- WMKDUJVLNZANRN-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(Br)=C2)C=N1
- CAS DataBase Reference
- 79762-54-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-41
- Safety Statements
- 26-36/37-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 702447
- Product name
- 6-Bromo-1H-indazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $93.5
- Updated
- 2023/06/20
- Product number
- B4080
- Product name
- 6-Bromoindazole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B4080
- Product name
- 6-Bromoindazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- B4080
- Product name
- 6-Bromoindazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $218
- Updated
- 2025/07/31
- Product number
- B415315
- Product name
- 6-Bromo-1H-indazole
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
6-Bromoindazole Chemical Properties,Usage,Production
Uses
6-Bromo-1H-indazole is an indazole derivative being studied as an inhibitor of DNA gyrase B and its antibacterial activity.
Synthesis
57848-46-1
79762-54-2
General procedure for the synthesis of 6-bromo-1H-indazole from 4-bromo-2-fluorobenzaldehyde: Hydrazine hydrate (30 mL, 832 mmol) and 4-bromo-2-fluorobenzaldehyde (4.69 g, 23 mmol) were added to a 100 mL round bottom flask. The reaction mixture was stirred at 125 °C for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction solution was subsequently concentrated under reduced pressure. The concentrated reaction solution was quenched by pouring it into an ice-water mixture (100 mL) and then extracted with ethyl acetate (3 × 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and filtered to remove the desiccant. The filtrate was concentrated to dryness under reduced pressure, and the resulting crude product was adsorbed on silica gel. The crude product was purified by column chromatography using a Redi-Sep pre-populated silica gel column (40 g) with hexane/ethyl acetate (0 to 100% gradient) as eluent to give the final 6-bromo-1H-indazole (4.6 g, 18 mmol, 76% yield). The product was detected by LCMS, [M + H]+ m/z 197.9 (calculated value C7H5BrN2 197.0).1H NMR (400 MHz, CD3OD): δ 8.03 (s, 1H), 7.67-7.72 (m, 2H), 7.24-7.26 (m, 1H).
References
[1] Patent: CN106146401, 2016, A. Location in patent: Paragraph 0117; 0190; 0191
[2] Patent: US2015/368278, 2015, A1. Location in patent: Paragraph 1273; 1274
[3] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8166 - 8172
[4] Patent: US2007/173506, 2007, A1. Location in patent: Page/Page column 48
[5] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
6-Bromoindazole Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromoindazole Suppliers
- Tel
- --
- Fax
- --
- info@borochem.fr
- Country
- France
- ProdList
- 852
- Advantage
- 46
View Lastest Price from 6-Bromoindazole manufacturers
- Product
- 6-Bromoindazole 79762-54-2
- Price
- US $1.00/kg
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-06-09
- Product
- 6-Bromoindazole 79762-54-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 6-Bromoindazole 79762-54-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31